Efficacy of a novel water-soluble curcumin derivative versus sildenafil citrate in mediating erectile function

International Journal of Impotence Research

Volumn 27, Issue 1, 2015, Pages 9-15

  Zaahkouk, A M S ^a   Abdel Aziz, M T ^b   Rezq, A M ^b   Atta, H M ^b,c   Fouad, H H ^b   Ahmed, H H ^b   Sabry, D ^b   Yehia, M H ^a  

^a Assiut Branch   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; CYCLIC GMP; GLUCOSE 6 PHOSPHATE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SILDENAFIL; TRANSCRIPTION FACTOR NRF2; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONAMIDE; WATER;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES CONTROL; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ERECTILE DYSFUNCTION; GENE EXPRESSION; MALE; NONHUMAN; PENIS ERECTION; RAT; SINGLE DRUG DOSE; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; CHEMISTRY; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ELECTROSTIMULATION; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENETICS; INNERVATION; METABOLISM; PATHOPHYSIOLOGY; PENIS; PRESSURE; SOLUBILITY;

ANIMALS; BIOLOGICAL AVAILABILITY; CURCUMIN; CYCLIC GMP; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ERECTILE DYSFUNCTION; GENE EXPRESSION; HEME OXYGENASE-1; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE; PENIS; PIPERAZINES; PRESSURE; PURINES; RATS; SOLUBILITY; SULFONAMIDES; WATER;

EID: 84920515115     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/ijir.2014.24     Document Type: Article

References (39)

1. Abdel Aziz MT, El-Asmer MF, Mostafa T, Mostafa S, Atta H, Wassef MA et al. Heme oxygenase versus nitric oxide synthase in signaling mediating sildenafil citrate action. J Sex Med 2007; 4: 1098-1107.
2. Abdel Aziz MT, Mostafa T, Atta H, Wassef MA, Fouad HH, Rashed LA et al. Putative role of carbon monoxide signaling pathway in penile erectile function. J Sex Med 2009; 6: 49-60.
3. Hua W, Chen Q, Gong F, Xie C, Zhou S, Gao L. Cardioprotection of H2S by downregulating iNOS and upregulating HO-1 expression in mice with CVB3-induced myocarditis. Life Sci 2013; 93: 949-954.
4. D'Araio E, Shaw N, Millward A, Demaine A, Whiteman M, Hodgkinson A. Hydrogen sulfide induces heme oxygenase-1 in human kidney cells. Acta Diabetol 2013; 51: 155-157.
5. Abdel Aziz MT, Mostafa T, Atta H, Rashed L, Marzouk SA, Obaia EM et al. The role of PDE5 inhibitors in heme oxygenase-cGMP relationship in rat cavernous tissues. J Sex Med 2008; 5: 1636-1645.
6. Andreadi CK, Howells LM, Atherfold PA, Manson MM. Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of heme oxygenase-1 by dietary polyphenols. Mol Pharmacol 2006; 69: 1033-1040.
7. Zhao R, Yang B, Wang L, Xue P, Deng B, Zhang G et al. Curcumin protects human keratinocytes against inorganic arsenite-induced acute cytotoxicity through an NRF2-dependent mechanism. Oxid Med Cell Longev 2013; 2013: 412576.
8. Abdel Aziz MT, El Asmer MF, Rezq A, Kumosani TA, Mostafa S, Mostafa T et al. Novel water soluble curcumin derivative mediates erectile signaling. J Sex Med 2010; 7: 2714-2722.
9. Gao S, Duan X, Wang X, Dong D, Liu D, Li X et al. Curcumin attenuates arsenicinduced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol 2013; 59: 739-747.
10. Soetikno V, Sari FR, Lakshmanan AP, Arumugam S, Harima M, Suzuki K et al. Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway. Mol Nutr Food Res 2013; 57: 1649-1659.
11. Hill-Kapturczak N, Thamilselvan V, Liu F, Nick HS, Agarwal A. Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells. Am J Physiol Renal Physiol 2001; 281: F851-F859.
12. Xu PH, Long Y, Dai F, Liu ZL. The relaxant effect of curcumin on porcine coronary arterial ring segments. Vascul Pharmacol 2007; 47: 25-30.
13. Schini-Kerth VB, Auger C, Étienne-Selloum N, Chataigneau T. Polyphenol-induced endothelium-dependent relaxations. Role of NO and EDHF. Adv Pharmacol 2010; 60: 136-175.
14. Subramani PA, Narala VR. Challenges of curcumin bioavailability: novel aerosol remedies. Nat Prod Commun 2013; 8: 121-124.
15. Rezq AM, Abdel Aziz MT, Al-Malki AL. Gelatin, a novel curcumin drug carrier system, WO/2011/100984. World Intellect Prop Org (WIPO) 2011, http://patents cope.wipo.int/search/en/detail.jsf%3Bjsessionid\+90C05C7570FE02B89EBE9013FC25D794. wapp1?docId=WO2011100984&recNum=72&office=&queryString=&prevFilter= &sortOption=Pub\+Date\+Desc&maxRec=8021524.
16. Hu J-J, Gu H-Y, Ding W-L, Yuan S-J, Zhong M-F, Liu L. Correlation between nNOS expression and erectile dysfunction in experimental diabetes mellitus rats of different ages. Neuroembryol Aging 2008; 5: 144-150.
17. Li WJ, Zhou J, Li B, Wang H, Peng YB, Wang Z. PARP inhibition restores erectile function by suppressing corporal smooth muscle apoptosis in diabetic rats. J Sex Med 2011; 8: 1072-1082.
18. Paget GE, Barnes GM. Evaluation of Drug Activities Vol. 1. Academic Press: London, 1964 135.
19. Abdel Aziz MT, Abraham N, Mostafa T, Mahfouz S, Atta H, Wassef MA et al. Heme oxygenase-1 (HO-1) gene transfer and CORM-3 as therapeutic modalities in erectile dysfunction. Andrologia 2008; 5: 363-343.
20. Moshag H, Kok B, Huizenga JR, Jansen LK. Nitrite and nitrate determination in plasma: a critical evaluation. Clin Chem 1995; 41: 892-896.
21. Abdel Aziz MT, Motawi T, Rezq A, Mostafa T, Fouad HH, Ahmed HH et al. Effects of a water-soluble curcumin protein conjugate vs. pure curcumin in a diabetic model of erectile dysfunction. J Sex Med 2012; 9: 1815-1833.
22. Xia ZW, Zhou WP, Cui WJ, Zhang XH, Shen QX, Li YZ et al. Structure prediction and activity analysis of human heme oxygenase-1 and its mutant. World J Gastroenterol 2004; 10: 2352-2356.
23. Mulhall JP, Verma N, Deveci S, Tal R, Kobylarz K, Mü ller A. Sildenafil citrate improves erectile function after castration in a rat model. BJU Int 2013; 113: 656-661.
24. Strong TD, Gebska MA, Burnett AL, Champion HC, Bivalacqua TJ. Endotheliumspecific gene and stem cell-based therapy for erectile dysfunction. Asian J Androl 2008; 10: 14-22.
25. Yang G, Lucas R, Caldwell R, Yao L, Romero MJ, Caldwell RW. Novel mechanisms of endothelial dysfunction in diabetes. J Cardiovasc Dis Res 2010; 1: 59-63.
26. Xu J, Zou MH. Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation 2009; 120: 1266-1286.
27. Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB. Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. J Biol Chem 2003; 31: 28793-28798.
28. Chen Z, Singer WD, Sternweis PC, Sprang SR. Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator. Nat Struct Mol Biol 2005; 2: 191-197.
29. Romero MJ, Platt DH, Tawfik HE, Labazi M, El-Remessy AB, Bartoli M et al. Diabetes-induced coronary vascular dysfunction involves increased arginase activity. Circ Res 2008; 1: 95-102.
30. Zhang C. The role of inflammatory cytokines in endothelial dysfunction. Basic Res Cardiol 2008; 103: 398-406.
31. Abdel Aziz MT, El Asmer MF, Mostafa T, Atta H, Mahfouz S, Fouad H et al. Effects of losartan, HO-1 inducers or HO-1 inhibitors on erectile signaling in diabetic rats. J Sex Med 2009; 6: 3254-3264.
32. Hamed S, Brenner B, Roguin A. Nitric Oxide: a key factor behind the dysfunctionality of endothelial progenitor cells in diabetes mellitus type-2. Cardiovasc Res 2011; 91: 9-15.
33. Wan ZH, Li WZ, Li YZ, Chen L, Li GH, Hu WF et al. Poly(ADP-Ribose) polymerase inhibition improves erectile function in diabetic rats. J Sex Med 2011; 8: 1002-1014.
34. Rungseesantivanon S, Thenchaisri N, Ruangvejvorachai P, Patumraj S. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med 2010; 10: 57.
35. Usharani P, Mateen A, Naidu M, Raju Y, Chandra N. Effect of NCB-02, Atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with T2 diabetes mellitus: a randomized, parallel-group, placebocontrolled, 8-week study. Drug R D 2008; 9: 243-250.
36. Ahmad M, Turkseven S, Mingone CJ, Gupte SA, Wolin MS, Abraham NG. Heme oxygenase-1 gene expression increases vascular relaxation and decreases inducible nitric oxide synthase in diabetic rats. Cell Mol Biol 2005; 51: 371-376.
37. Ryter SW, Otterbein LE, Morse D, Choi AM. Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol Cell Biochem 2002; 234-235: 249-263.
38. Shamloul R. The potential role of the heme oxygenase/carbon monoxide system in male sexual dysfunctions. J Sex Med 2009; 6: 324-333.
39. Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 2009; 30: 85-94.