Heme oxygenase vs. nitric oxide synthase in signaling mediating sildenafil citrate action

Journal of Sexual Medicine

Volumn 4, Issue 4 II, 2007, Pages 1098-1107

  Abdel Aziz, M Talaat ^a   El Asmer, Mohamed Farid ^b   Mostafa, Taymour ^a   Mostafa, Samia ^a   Atta, Hazem ^a   Aziz Wassef, M Abdel ^a   Fouad, Hanan ^a   Rashed, Laila ^a   Sabry, Dina ^a   Mahfouz, Soheir ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

Carbon monoxide; Corpus cavernosum; Erectile dysfunction; Heme oxygenase; Nitric oxide; Sildenafil citrate

Indexed keywords

CURCUMIN; CYCLIC GMP; HEME OXYGENASE 1; HEME OXYGENASE 2; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTOPORPHYRIN ZINC; SILDENAFIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; STOMACH TUBE; TISSUE LEVEL; UPREGULATION; VASODILATATION; WESTERN BLOTTING;

EID: 34447521497     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2007.00533.x     Document Type: Article

References (46)

1. Hellstrom WJ. The molecular basis of erectile physiology: From bench to bedside. J Androl 2002; 23: S3-4.
2. Burnett AL. Nitric oxide in the penis-science and therapeutic implications from erectile dysfunction to priapism. J Sex Med 2006; 3: 578-82.
3. Craven M, Sergeant GP, Hollywood MA, McHale NG, Thornbury KD. Modulation of spontaneous Ca2+ activated Cl-currents in the rabbit corpus cavernosum by the nitric oxide cGMP pathway. J Physiol 2004; 556: 495-506.
4. Seftel AD. Phosphodiesterase type 5 inhibitors: Molecular pharmacology and interactions with other phosphodiesterases. Curr Pharm Des 2005; 11: 4047-58.
5. Cremers B, Bohm M. Non erectile dysfunction application of sildenafil. Herz 2003; 28: 325-33.
6. Maines MD. The heme oxygenase system: Past, present and future. Antioxid Redox Signal 2004; 6: 797-801.
7. Sammut IA, Foresti R, Clark JE, Exon DJ, Vesely MJJ, Sarathchandra P, Green CJ, Motterlini R. Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of heme oxygenase-1. Br J Pharmacol 1998; 125: 1437-44.
8. Wang J, Lu S, Moenne P, Montellano OR. Interaction of nitric oxide with human heme oxygenase-1. J Biol Chem 2003; 278: 2341-7.
9. Abdel-Aziz MT, El-Asmar MF, Mostafa T, Atta H, Abdel Aziz M, Fouad H, Roshdy N, Rashed L, Sabry D. Effects of nitric oxide synthase and heme oxygenase inducers and inhibitors on molecular signaling of erectile function. Clin Biochem Nut (Japan) 2005; 37: 103-11.
10. Hedlund P, Ny L, Alm P, Andersson KE. Cholinergic nerves in human corpus cavernosum and spongiosum contain nitric oxide synthase and heme oxygenase. J Urol 2000; 164 (3 Pt 1): 868-75.
11. Qiao L, Xin ZC. Advances in the research about penile erection related genes. Zhonghua Nan Ke Xue 2002; 8: 363-6.
12. Shamloul R, Wang R. Increased intracavernosal pressure response in hypertensive rats after chronic hemin treatment. J Sex Med 2006; 3: 619-27.
13. Paget GE, Barnes GM. Evaluation of drug activities, Vol. 1. London: Academic Press; 1964: 135.
14. Tajuddin AS, Latif A, Qasmi IA. Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behavior of normal male rats. BMC Complement Altern Med 2004; 4: 17.
15. Tajuddin AS, Latif A, Qasmi IA. Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L.) Merr. & Perry. (clove) in male mice: A comparative study. BMC Complement Altern Med 2003; 3: 6.
16. Mahesh T, Sri Balasubashini MM, Menon VP. Photo-irradiated curcumin supplementation in streptozotocin-induced diabetic rats: Effect on lipid peroxidation. Therapie 2004; 59: 639-44.
17. Masini E, Vannacci A, Marzocca C, Pierpaoli S, Giannini L, Fantappie O, Mazzanti R, Mannaioni PF. Heme oxygenase-1 and the ischemia-reperfusion injury in the rat heart. Exp Biol Med (Maywood) 2003; 228: 546-9.
18. Mayer RD, Wang X, Maines MD. Nitric oxide inhibitor N omega-nitro-L-arginine methyl ester potentiates induction of heme oxygenase-1 in kidney ischemia/reperfusion model: A novel mechanism for regulation of the oxygenase. J Pharmacol Exp Ther 2003; 306: 43-50.
19. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction method. Anal Biochem 1987; 162: 156-9.
20. Hoshida S, Nishida M, Yamashita N, Igarashi J, Aoki K, Hori M, Kuzuya T, Tada M. Heme oxygenase-1 expression and its relation to oxidative stress during primary culture of cardiomyocytes. J Mol Cell Cardiol 1996; 28: 1845-55.
21. Angulo J, Cuevas P, Fernandez A, Gabancho S, Allona A, Martin-Morales A, Moncada I, Saenz de Tejada I. Activation and potentiation of NO/cGMP pathway by NG-hydroxyl-L-arginine in rabbit corpus cavernosum under normoxic and hypoxic conditions and aging. Br J Pharmacol 2003; 138: 63-70.
22. Abraham NG, Lutton JD, Levere RD. Heme metabolism and erythropoiesis in abnormal iron states. Role of aminolevulinic acid synthetase and heme oxygenase. Exp Haematol 1985; 13: 833-43.
23. Mingone CJ, Gupte SA, Quan S, Abraham NG, Wolin MS. Influence of heme and heme oxygense-1 transfection of pulmonary microvascular endothelialium on oxidant generation and cGMP. Exp Biol Med 2003; 228: 535-9.
24. Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour M, Williams JW. Estrogen-induced abnormal accumulation of fat cells in the rat penis and associated loss of fertility depends upon estrogen exposure during critical period of penile development. Toxicol Sci 2005; 87: 242-54.
25. Althof SE, O'leary MP, Cappelleri JC, Hvidsten K, Stecher VJ, Glina S, King R, Siegel RL, International SEAR Study Group. Sildenafil citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: Results from an international, multi-center, double-blind, placebo-controlled trial. J Sex Med 2006; 3: 521-9.
26. Lowy M, Collins S, Bloch M, Gillman M, Lording D, Sutherland P, Wang H, Stecher V. Quality of erection questionnaire correlates: Change in erection quality with erectile function, hardness, and psychosocial measures in men treated with sildenafil for erectile dysfunction. J Sex Med 2007; 4: 83-92.
27. Patil CS, Singh VP, Kulkarni SK. Modulatory effect of sildenafil in diabetes and electroconvulsive shock-induced cognitive dysfunction in rats. Pharmacol Rep 2006; 58: 373-80.
28. Rossoni G, Manfredi B, De Gennaro Colonna V, Berti M, Guazzi M, Berti F. Sildenafil reduces L-NAME-induced severe hypertension and worsening of myocardial ischaemia-reperfusion damage in the rat. Br J Pharmacol 2007; 150: 567-76.
29. Ferrini MG, Kovanecz I, Sanchez S, Vernet D, Davila HH, Rajfer J, Gonzalez-Cadavid NF. Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat. Biol Reprod 2007; 76: 915-23.
30. Valente EG, Vernet D, Ferrini MG, Qian A, Rajfer J, Gonzalez-Cadavid NF. PDE 1-arginine and PDE inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures. Nitric Oxide 2003; 9: 229-44.
31. Abdel Aziz MT, Mostafa T, Atta H, Rashed L, Marzouk S, Obaia E, Hassouna A, El-Shehaby A, Abdel Aziz A. Oral phosphodiesterase-5 inhibitors: Effect of heme oxygenase inhibition on cGMP signalling in rat cavernous tissue. Andrologia 2007; 9: 377-81.
32. Serfass L, Burstyn JN. Effect of heme oxygenase inhibitors on soluble guanylate cyclase activity. Arch Biochem Biophys 1998; 359: 8-16.
33. Ny L, Andersson KE, Grundemar L. Inhibition by zinc protoporphyrin-IX of receptor mediated relaxation of the rat aorta in a manner distinct from inhibition of heme oxygenase. Br J Pharmacol 1995; 115: 186-90.
34. Hirai K, Sasahira T, Ohmori H, Fujii K, Kuniyasu H. Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice. Int J Cancer 2007; 120: 500-5.
35. Vidavalur R, Penumathsa SV, Zhan L, Thirunavukkarasu M, Maulik N. Sildenafil induces angiogenic response in human coronary arteriolar endothelial cells through the expression of thioredoxin, hemeoxygenase and vascular endothelial growth factor. Vascul Pharmacol 2006; 45: 91-5.
36. Zakhary R, Poss KD, Jaffrey SR, Ferris CD, Tonegawa S, Snyder SH. Targeted gene deletion of heme oxygenase-s 2 reveals neural role for carbon monoxide. Proc Natl Acad Sci USA 1997; 94: 14848-53.
37. Rich A, Farrugia G, Rae JL. Carbon monoxide stimulates a potassium selective current in rabbit corneal epithelial cells. Am J Physiol 1994; 267 (2 Pt 1): C435-42.
38. Wang R, Wang Z, Wu L. Carbon monoxide-induced vasorelaxation and the underlying mechanisms. Br J Pharmacol 1997; 121: 927-34.
39. Abraham NG, Quan S, Mieyal PA, Yang L, Burke-Wolin T, Mingone CJ, Goodman AL, Nasjletti A, Wolin MS. Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells. Am J Physiol Lung Cell Mol Physiol 2002; 283: L1117-24.
40. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ. Carbon monoxide-releasing molecules: Characterization of biochemical and vascular activities. Circ Res 2002; 90: E17-24.
41. Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R, Motterlini R. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ Res 2003; 93: E2-8.
42. Di Pascoli M, Rodella L, Sacerdoti D, Bolognesi M, Turkseven S, Abraham NG. A Chronic CO level has a beneficial effect on vascular relaxation in diabetes. Biochem Biophys Res Commun 2005; 340: 935-43.
43. Ahmad M, Turkseven S, Mingone CJ, Gupte SA, Wolin MS, Abraham NG. Heme oxygenase-1 gene expression increases vascular relaxation and decreases inducible nitric oxide synthase in diabetic rats. Cell Mol Biol 2005; 51: 371-6.
44. Marks GS, Brien JF, Nakatsu K. What role does the heme-heme oxygenase-carbon monoxide system play in vasoregulation? Am J Physiol Regul Integr Comp Physiol 2003; 285: R522-3.
45. Ryter SW, Morse D, Choi AM. Carbon monoxide: To boldly go where nitric oxide has gone before. Sci STKE 2004; 230: RE6.
46. Ryter SW, Otterbein LE, Morse D, Choi AM. Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance. Mol Cell Biochem 2002; 234-235, 249-63.