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Volumn 8, Issue 4, 2011, Pages 1072-1082

PARP Inhibition Restores Erectile Function by Suppressing Corporal Smooth Muscle Apoptosis in Diabetic Rats

Author keywords

Animal Model; Apoptosis; Diabetes; Erectile Dysfunction; Poly(ADPribose) Polymerase; Smooth Muscle

Indexed keywords

3 AMINOBENZAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

EID: 79953316405     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.02176.x     Document Type: Article
Times cited : (26)

References (43)
  • 2
    • 0038487156 scopus 로고    scopus 로고
    • Optimizing treatment for diabetes mellitus induced erectile dysfunction
    • Costabile RA. Optimizing treatment for diabetes mellitus induced erectile dysfunction. J Urol 2003;170:S35-8.
    • (2003) J Urol , vol.170
    • Costabile, R.A.1
  • 5
    • 14344264330 scopus 로고    scopus 로고
    • Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: A potential mechanism for veno-occlusive dysfunction in androgen deficiency
    • Traish AM, Toselli P, Jeong SJ, Kim NN. Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: A potential mechanism for veno-occlusive dysfunction in androgen deficiency. J Androl 2005;26:242-8.
    • (2005) J Androl , vol.26 , pp. 242-248
    • Traish, A.M.1    Toselli, P.2    Jeong, S.J.3    Kim, N.N.4
  • 7
    • 33644811639 scopus 로고    scopus 로고
    • Vasculogenic erectile dysfunction: Beyond the haemodynamic changes
    • Azadzoi KM. Vasculogenic erectile dysfunction: Beyond the haemodynamic changes. BJU Int 2006;97:11-6.
    • (2006) BJU Int , vol.97 , pp. 11-16
    • Azadzoi, K.M.1
  • 9
    • 0346728613 scopus 로고    scopus 로고
    • Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: A possible cause for erectile dysfunction in diabetes
    • Jesmin S, Sakuma I, Salah-Eldin A, Nonomura K, Hattori Y, Kitabatake A. Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: A possible cause for erectile dysfunction in diabetes. J Mol Endocrinol 2003;31:401-18.
    • (2003) J Mol Endocrinol , vol.31 , pp. 401-418
    • Jesmin, S.1    Sakuma, I.2    Salah-Eldin, A.3    Nonomura, K.4    Hattori, Y.5    Kitabatake, A.6
  • 10
    • 0037664875 scopus 로고    scopus 로고
    • Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats
    • Yamanaka M, Shirai M, Shiina H, Tanaka Y, Tsujimura A, Matsumiya K, Okuyama A, Dahiya R. Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats. J Urol 2003;170:291-7.
    • (2003) J Urol , vol.170 , pp. 291-297
    • Yamanaka, M.1    Shirai, M.2    Shiina, H.3    Tanaka, Y.4    Tsujimura, A.5    Matsumiya, K.6    Okuyama, A.7    Dahiya, R.8
  • 11
    • 10344242040 scopus 로고    scopus 로고
    • Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura
    • Yamanaka M, Shirai M, Shiina H, Tanaka Y, Enokida H, Tsujimura A, Matsumiya K, Okuyama A, Dahiya R. Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura. J Urol 2005;173:318-23.
    • (2005) J Urol , vol.173 , pp. 318-323
    • Yamanaka, M.1    Shirai, M.2    Shiina, H.3    Tanaka, Y.4    Enokida, H.5    Tsujimura, A.6    Matsumiya, K.7    Okuyama, A.8    Dahiya, R.9
  • 12
    • 42749093303 scopus 로고    scopus 로고
    • Chronic treatment with a type 5 phosphodiesterase inhibitor suppresses apoptosis of corporal smooth muscle by potentiating Akt signalling in a rat model of diabetic erectile dysfunction
    • Park K, Ryu KS, Li WJ, Kim SW, Paick JS. Chronic treatment with a type 5 phosphodiesterase inhibitor suppresses apoptosis of corporal smooth muscle by potentiating Akt signalling in a rat model of diabetic erectile dysfunction. Eur Urol 2008;53:1282-8.
    • (2008) Eur Urol , vol.53 , pp. 1282-1288
    • Park, K.1    Ryu, K.S.2    Li, W.J.3    Kim, S.W.4    Paick, J.S.5
  • 13
    • 78650779521 scopus 로고    scopus 로고
    • Chronic treatment with an oral Rho-kinase inhibitor restores erectile function by suppressing corporal apoptosis in diabetic rats
    • Mar 2 [Epub ahead of print] doi: 10.1111/j.1743-6109.2010.01724.x.
    • Li WJ, Park K, Paick JS, Kim SW. Chronic treatment with an oral Rho-kinase inhibitor restores erectile function by suppressing corporal apoptosis in diabetic rats. J Sex Med 2010 Mar 2 [Epub ahead of print] doi: 10.1111/j.1743-6109.2010.01724.x.
    • (2010) J Sex Med
    • Li, W.J.1    Park, K.2    Paick, J.S.3    Kim, S.W.4
  • 14
    • 33745088146 scopus 로고    scopus 로고
    • Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus
    • Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus. BJU Int 2006;98:116-24.
    • (2006) BJU Int , vol.98 , pp. 116-124
    • Kovanecz, I.1    Ferrini, M.G.2    Vernet, D.3    Nolazco, G.4    Rajfer, J.5    Gonzalez-Cadavid, N.F.6
  • 15
    • 77649189371 scopus 로고    scopus 로고
    • Molecular pathology of oxidative stress in diabetic angiopathy: Role of mitochondrial and cellular pathways
    • Mokini Z, Marcovecchio ML, Chiarelli F. Molecular pathology of oxidative stress in diabetic angiopathy: Role of mitochondrial and cellular pathways. Diabetes Res Clin Pract 2010;87:313-21.
    • (2010) Diabetes Res Clin Pract , vol.87 , pp. 313-321
    • Mokini, Z.1    Marcovecchio, M.L.2    Chiarelli, F.3
  • 16
    • 27744509592 scopus 로고    scopus 로고
    • Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications
    • Allen DA, Yaqoob MM, Harwood SM. Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications. J Nutr Biochem 2005;16:705-13.
    • (2005) J Nutr Biochem , vol.16 , pp. 705-713
    • Allen, D.A.1    Yaqoob, M.M.2    Harwood, S.M.3
  • 17
    • 34547444891 scopus 로고    scopus 로고
    • Mechanistic insights into diabetes mellitus and oxidative stress
    • Maiese K, Chong ZZ, Shang YC. Mechanistic insights into diabetes mellitus and oxidative stress. Curr Med Chem 2007;14:1729-38.
    • (2007) Curr Med Chem , vol.14 , pp. 1729-1738
    • Maiese, K.1    Chong, Z.Z.2    Shang, Y.C.3
  • 18
    • 18844395611 scopus 로고    scopus 로고
    • The pathogenesis of diabetic complications: The role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity
    • Kiss L, Szabo C. The pathogenesis of diabetic complications: The role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity. Mem Inst Oswaldo Cruz 2005;100(suppl):29-37.
    • (2005) Mem Inst Oswaldo Cruz , vol.100 , Issue.SUPPL. , pp. 29-37
    • Kiss, L.1    Szabo, C.2
  • 19
    • 28844462418 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: Endothelial dysfunction, as a common underlying theme
    • Pacher P, Szabo C. Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: Endothelial dysfunction, as a common underlying theme. Antioxid Redox Signal 2005;7:1568-80.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1568-1580
    • Pacher, P.1    Szabo, C.2
  • 20
    • 85047691537 scopus 로고    scopus 로고
    • Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
    • Du X, Matsumura T, Edelstein D, Rossetti L, Zsengeller Z, Szabo C, Brownlee M. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest 2003;112:1049-57.
    • (2003) J Clin Invest , vol.112 , pp. 1049-1057
    • Du, X.1    Matsumura, T.2    Edelstein, D.3    Rossetti, L.4    Zsengeller, Z.5    Szabo, C.6    Brownlee, M.7
  • 21
    • 0036733355 scopus 로고    scopus 로고
    • The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
    • Virag L, Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 2002;54:375-429.
    • (2002) Pharmacol Rev , vol.54 , pp. 375-429
    • Virag, L.1    Szabo, C.2
  • 22
    • 42249107850 scopus 로고    scopus 로고
    • PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2
    • Mathews MT, Berk BC. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arterioscler Thromb Vasc Biol 2008;28:711-7.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 711-717
    • Mathews, M.T.1    Berk, B.C.2
  • 23
    • 30444446344 scopus 로고    scopus 로고
    • Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion
    • Kovacs K, Toth A, Deres P, Kalai T, Hideg K, Gallyas F, Jr, Sumegi B. Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion. Biochem Pharmacol 2006;71:441-52.
    • (2006) Biochem Pharmacol , vol.71 , pp. 441-452
    • Kovacs, K.1    Toth, A.2    Deres, P.3    Kalai, T.4    Hideg, K.5    Gallyas Jr, F.6    Sumegi, B.7
  • 25
    • 34447509443 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling
    • Wang SJ, Wang SH, Song ZF, Liu XW, Wang R, Chi ZF. Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling. Neuroreport 2007;18:1285-9.
    • (2007) Neuroreport , vol.18 , pp. 1285-1289
    • Wang, S.J.1    Wang, S.H.2    Song, Z.F.3    Liu, X.W.4    Wang, R.5    Chi, Z.F.6
  • 27
    • 27444446861 scopus 로고    scopus 로고
    • Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress
    • Tapodi A, Debreceni B, Hanto K, Bognar Z, Wittmann I, Gallyas F, Jr, Varbiro G, Sumegi B. Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress. J Biol Chem 2005;280:35767-75.
    • (2005) J Biol Chem , vol.280 , pp. 35767-35775
    • Tapodi, A.1    Debreceni, B.2    Hanto, K.3    Bognar, Z.4    Wittmann, I.5    Gallyas Jr, F.6    Varbiro, G.7    Sumegi, B.8
  • 28
    • 77957332423 scopus 로고    scopus 로고
    • Poly(ADP-Ribose) Polymerase inhibition reverses nitrergic neurovascular dysfunctions in penile erectile tissue from streptozotocin-diabetic mice
    • Nangle MR, Cotter MA, Cameron NE. Poly(ADP-Ribose) Polymerase inhibition reverses nitrergic neurovascular dysfunctions in penile erectile tissue from streptozotocin-diabetic mice. J Sex Med 2010;10:3396-403.
    • (2010) J Sex Med , vol.10 , pp. 3396-3403
    • Nangle, M.R.1    Cotter, M.A.2    Cameron, N.E.3
  • 29
    • 79953324138 scopus 로고    scopus 로고
    • Poly(ADP-Ribose) polymerase inhibition improves erectile function in diabetic rats
    • Aug 30 [Epub ahead of print] doi: 10.1111/j.1743-6109.2010.01963.x.
    • Wan ZH, Li WZ, Li YZ, Chen L, Li GH, Hu WF, Peng S, Yu JJ, Guo F. Poly(ADP-Ribose) polymerase inhibition improves erectile function in diabetic rats. J Sex Med 2010 Aug 30 [Epub ahead of print] doi: 10.1111/j.1743-6109.2010.01963.x.
    • (2010) J Sex Med
    • Wan, Z.H.1    Li, W.Z.2    Li, Y.Z.3    Chen, L.4    Li, G.H.5    Hu, W.F.6    Peng, S.7    Yu, J.J.8    Guo, F.9
  • 30
    • 0042330416 scopus 로고    scopus 로고
    • Role of apoptosis-inducing factor in myocardial cell death by ischemia-reperfusion
    • Kim GT, Chun YS, Park JW, Kim MS. Role of apoptosis-inducing factor in myocardial cell death by ischemia-reperfusion. Biochem Biophys Res Commun 2003;309:619-24.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 619-624
    • Kim, G.T.1    Chun, Y.S.2    Park, J.W.3    Kim, M.S.4
  • 32
    • 67649526000 scopus 로고    scopus 로고
    • Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos
    • Wang Y, Dawson VL, Dawson TM. Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos. Exp Neurol 2009;218:193-202.
    • (2009) Exp Neurol , vol.218 , pp. 193-202
    • Wang, Y.1    Dawson, V.L.2    Dawson, T.M.3
  • 33
    • 40649118790 scopus 로고    scopus 로고
    • Long-term continuous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats
    • Kovanecz I, Rambhatla A, Ferrini M, Vernet D, Sanchez S, Rajfer J, Gonzalez-Cadavid N. Long-term continuous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats. Int J Impot Res 2008;20:202-12.
    • (2008) Int J Impot Res , vol.20 , pp. 202-212
    • Kovanecz, I.1    Rambhatla, A.2    Ferrini, M.3    Vernet, D.4    Sanchez, S.5    Rajfer, J.6    Gonzalez-Cadavid, N.7
  • 35
    • 35748970514 scopus 로고    scopus 로고
    • PARP inhibitor development for systemic cancer targeting
    • Zaremba T, Curtin NJ. PARP inhibitor development for systemic cancer targeting. Anticancer Agents Med Chem 2007;7:515-23.
    • (2007) Anticancer Agents Med Chem , vol.7 , pp. 515-523
    • Zaremba, T.1    Curtin, N.J.2
  • 38
    • 0037239590 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors
    • Southan GJ, Szabo C. Poly(ADP-ribose) polymerase inhibitors. Curr Med Chem 2003;10:321-40.
    • (2003) Curr Med Chem , vol.10 , pp. 321-340
    • Southan, G.J.1    Szabo, C.2
  • 39
    • 10644269399 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents
    • Bryant HE, Helleday T. Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents. Biochem Soc Trans 2004;32:959-61.
    • (2004) Biochem Soc Trans , vol.32 , pp. 959-961
    • Bryant, H.E.1    Helleday, T.2
  • 40
    • 33644681565 scopus 로고    scopus 로고
    • Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: The relation is revisited
    • Obrosova IG, Drel VR, Pacher P, Ilnytska O, Wang ZQ, Stevens MJ, Yorek MA. Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: The relation is revisited. Diabetes 2005;54:3435-41.
    • (2005) Diabetes , vol.54 , pp. 3435-3441
    • Obrosova, I.G.1    Drel, V.R.2    Pacher, P.3    Ilnytska, O.4    Wang, Z.Q.5    Stevens, M.J.6    Yorek, M.A.7
  • 41
    • 0041703027 scopus 로고    scopus 로고
    • Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation
    • Minchenko AG, Stevens MJ, White L, Abatan OI, Komjati K, Pacher P, Szabo C, Obrosova IG. Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. FASEB J 2003;17:1514-6.
    • (2003) FASEB J , vol.17 , pp. 1514-1516
    • Minchenko, A.G.1    Stevens, M.J.2    White, L.3    Abatan, O.I.4    Komjati, K.5    Pacher, P.6    Szabo, C.7    Obrosova, I.G.8
  • 43
    • 77956041244 scopus 로고    scopus 로고
    • Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide
    • Pandya KG, Patel MR, Lau-Cam CA. Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide. J Biomed Sci 2010;17(suppl):S16.
    • (2010) J Biomed Sci , vol.17 , Issue.SUPPL.
    • Pandya, K.G.1    Patel, M.R.2    Lau-Cam, C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.