Questioning the preclinical paradigm: Natural, extreme biology as an alternative discovery platform

Aging

Volumn 6, Issue 11, 2014, Pages 913-920

  Buffenstein, Rochelle ^a   Nelson, O Lynne ^b   Corbit, Kevin C ^c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c AMGEN INC   (United States)

Author keywords

Aging; Cancer resistance; Cardiac function; Extremophiles; Grizzly bear; Insulin sensitivity; Naked mole rat; Obesity; Preclinical models

Indexed keywords

ADAPTATION; AGING; ANIMAL; ANIMAL MODEL; EVOLUTION; HUMAN; MASS COMMUNICATION; MOUSE; PRECLINICAL STUDY; PROCEDURES; RAT; SPECIES DIFFERENCE; TRANSLATIONAL RESEARCH; TRENDS;

ADAPTATION, PHYSIOLOGICAL; AGING; ANIMALS; BIOLOGICAL EVOLUTION; DIFFUSION OF INNOVATION; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; MODELS, ANIMAL; RATS; SPECIES SPECIFICITY; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84920288663     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100704     Document Type: Review

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