Aerosolized bovine lactoferrin reduces lung injury and fibrosis in mice exposed to hyperoxia

BioMetals

Volumn 27, Issue 5, 2014, Pages 1057-1068

  Chen, Hsiao Ling ^a   Yen, Chih Ching ^b,c,d   Wang, Shih Ming ^b   Tsai, Tung Chou ^b   Lai, Zi Lun ^b   Sun, Jheng Yue ^b   Lin, Willei ^e   Hsu, Wu Huei ^c   Chen, Chuan Mu ^b  

^a DA YEH UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Aerosol therapy; Bovine lactoferrin; Hyperoxic lung injury; Lung fibrosis; Oxygen toxicity

Indexed keywords

CYTOKINE; IMMUNOLOGIC FACTOR; LACTOFERRIN;

ANIMAL; APOPTOSIS; BIOSYNTHESIS; BOVINE; COMPLICATION; DISEASE MODEL; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG THERAPY; FEMALE; GENETICS; HUMAN; HYPEROXIA; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; INSTITUTE FOR CANCER RESEARCH MOUSE; LUNG INJURY; MOUSE; PATHOLOGY; PULMONARY FIBROSIS;

ADMINISTRATION, INHALATION; ANIMALS; APOPTOSIS; CATTLE; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; HYPEROXIA; IMMUNOLOGIC FACTORS; INFLAMMATION; LACTOFERRIN; LUNG INJURY; MICE; MICE, INBRED ICR; PULMONARY FIBROSIS;

EID: 84920276609     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-014-9750-7     Document Type: Article

References (48)

1. Actor JK, Hwang SA, Kruzel ML (2009) Lactoferrin as a natural immune modulator. Curr Pharm Des 15:1956-1973
2. Ando K, Hasegawa K, Shindo K, Furusawa T, Fujino T, Kikugawa K, Nakano H, Takeuchi O, Akira S, Akiyama T, Gohda J, Inoue J, Hayakawa M (2010) Human lactoferrin activates NF-kappaB through the toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J 277:2051-2066
3. Asikainen TM, White CW (2005) Antioxidant therapy for lung injury. In: Notter RH, Finkelstein JN, Holm BA (eds) Lung injury: mechanisms, pathophsiology, and therapy. Tayler & Francis Group Press, NY, pp 665-703
4. Bagby GC Jr, Bennett RM (1982) Feedback regulation of granulopoiesis: polymerization of lactoferrin abrogates its ability to inhibit CSA production. Blood 60:108-112
5. Brock JH (2002) The physiology of lactoferrin. Biochem Cell Biol 80:1-6
6. Chang LY, Subramaniam M, Yoder BA, Day BJ, Ellison MC, Sunday ME, Crapo JD (2003) A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Crit Care Med 167:57-64
7. Chen CM, Chen HL, Hsiau TH, Hsiau AH, Shi H, Brock GJ, Wei SH, Caldwell CW, Yan PS, Huang TH (2003) Methylation target array for rapid analysis of CpG island hypermethylation in multiple tissue genomes. Am J Pathol 163:37-45
8. Chen HL, Lai YW, Yen CC, Lin YY, Lu CY, Yang SH, Tsai TC, Lin YJ, Lin CW, Chen CM (2004) Production of recombinant porcine lactoferrin exhibiting antibacterial activity in methylotrophic yeast, Pichia pastoris. J Mol Microbiol Biotechnol 8:141-149
9. Chen HL, Wang LC, Chang CH, Yen CC, Cheng WT, Wu SC, Hung CM, Kuo MF, Chen CM (2008a) Recombinant porcine lactoferrin expressed in the milk of transgenic mice protects neonatal mice from a lethal challenge with enterovirus type 71. Vaccine 26:891-898
10. Chen YJ, Wu CY, Shen JL, Chu SY, Chen CK, Chang YT, Chen CM (2008b) Psoriasis independently associated with hyperleptinemia contributing to metabolic syndrome. Arch Dermatol 144:1571-1575
11. Chen HL, Lai YW, Chen CS, Chu TW, Lin W, Yen CC, Lin MF, Tu MY, Chen CM (2010) Probiotic lactobacillus casei expressing human lactoferrin elevates antibacterial activity in the gastrointestinal tract. Biometals 23:543-554
12. Chen JY, Chen HL, Cheng JC, Lin HJ, Tung YT, Lin CF, Chen CM (2012) A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine- induced liver fibrosis through inhibition of hepatic stellate cells proliferation. J Ethnopharmacol 142:811-818
13. Curran CS, Demick KP, Mansfield JM (2006) Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways. Cell Immunol 242:23-30
14. El-Loly MM, Mahfouz MB (2011) Lactoferrin in relation to biological functions and applications: a review. Int J Dairy Sci 6:79-111
15. Ghio AJ, Carter JD, Richards JH, Richer LD, Grissom CK, Elstad MR (2003) Iron and iron-related proteins in the lower respiratory tract of patients with acute respiratory distress syndrome. Crit Care Med 31:395-400
16. Griffiths CE, Cumberbatch M, Tucker SC, Dearman RJ, Andrew S, Headon DR, Kimber I (2001) Exogenous topical lactoferrin inhibits allergen-induced Langerhans cell migration and cutaneous inflammation in humans. Br J Dermatol 144:715-725
17. Guillen C, McInnes IB, Vaughan D, Speekenbrink AB, Brock JH (2000) The effects of local administration of lactoferrin on inflammation in murine autoimmune and infectious arthritis. Arthritis Rheum 43:2073-2080
18. Haversen L, Ohlsson BG, Hahn-Zoric M, Hanson LA, Mattsby-Baltzer I (2002) Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B. Cell Immunol 220:83-95
19. Holm BA, Chess PR, Notter RH (2005) Cell and animal models of lung injury. In: Notter RH, Finkelstein JN, Holm BA (eds) Lung injury: mechanisms, pathophsiology, and therapy. Tayler & Francis Group Press, NY, pp 366-370
20. Hung CM, Wu SC, Yen CC, Lin MF, Lai YW, Tung YT, Chen HL, Chen CM (2010a) Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination. Biometals 23:579-587
21. Hung CM, Yeh CC, Chen HL, Lai CW, Kuo MF, Yeh MH, Lin W, Tu MY, Cheng HC, Chen CM (2010b) Porcine lactoferrin administration enhances peripheral lymphocyte proliferation and assists infectious bursal disease vaccination in native chickens. Vaccine 28:2895-2902
22. Ioannou YA, Chen FW (1996) Quantitation of DNA fragmentation in apoptosis. Nucl Acids Res 24:992-993
23. Jiang D, Liang J, Li Y, Noble PW (2006) The role of Toll-like receptors in non-infectious lung injury. Cell Res 16:693-701
24. Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG (2010) Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 8:e1000412
25. Kruzel ML, Harari Y, Mailman D, Actor JK, Zimecki M (2002) Differential effects of prophylactic, concurrent and therapeutic lactoferrin treatment on LPS-induced inflammatory responses in mice. Clin Exp Immunol 130:25-31
26. Kruzel ML, Actor JK, Boldogh I, Zimecki M (2007) Lactoferrin in health and disease. Postepy Hig Med Dosw (Online) 61:261-267
27. Lagan AL, Melley DD, Evans TW, Quinlan GJ (2008) Pathogenesis of the systemic inflammatory syndrome and acute lung injury: role of iron mobilization and decompartmentalization. Am J Physiol Lung Cell Mol Physiol 294:161-174
28. Matute-Bello G, Frevert CW, Martin TR (2008) Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 295:L379-L399
29. Montuschi P, Ciabattoni G, Paredi P, Pantelidis P, du Bois RM, Kharitonov SA, Barnes PJ (1998) 8-isoprostane as a biomarker of oxidative stress in interstitial lung diseases. Am J Respir Crit Care Med 158:1524-1527
30. Montuschi P, Collins JV, Ciabattoni G, Lazzeri N, Corradi M, Kharitonov SA, Barnes PJ (2000) Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med 162:1175-1177
31. Nakao K, Imoto I, Gabazza EC, Yamauchi K, Yamazaki N, Taguchi Y, Shibata T, Takaji S, Ikemura N, Misaki M (1997) Gastric juice levels of lactoferrin and Helicobacter pylori infection. Scand J Gastroenterol 32:530-534
32. Paesano R, Pietropaoli M, Gessani S, Valenti P (2009) The influence of lactoferrin, orally administered, on systemic iron homeostasis in pregnant women suffering of iron deficiency and iron deficiency anaemia. Biochimie 91:44-51
33. Paesano R, Berlutti F, Pietropaoli M, Goolsbee W, Pacifici E, Valenti P (2010a) Lactoferrin efficacy versus ferrous sulfate in curing iron disorders in pregnant and non-pregnant women. Int J Immunopathol Pharmacol 23:577-587
34. Paesano R, Berlutti F, Pietropaoli M, Pantanella F, Pacifici E, Goolsbee W, Valenti P (2010b) Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women. Biometals 23:411-417
35. Paesano R, Pietropaoli M, Berlutti F, Valenti P (2012) Bovine lactoferrin in preventing preterm delivery associated with sterile inflammation. Biochem Cell Biol 90:468-475
36. Puddu P, Latorre D, Carollo M, Catizone A, Ricci G, Valenti P, Gessani S (2011) Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells. PLoS One 6:e22504
37. Simonson SG, Welty-Wolf KE, Huang YC, Taylor DE, Kantrow SP, Carraway MS, Crapo JD, Piantadosi CA (1997) Aerosolized manganese sod decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry. J Appl Physiol 83:550-558
38. Sinclair SE, Altemeier WA, Matute-Bello G, Chi EY (2004) Augmented lung injury due to interaction between hyperoxia and mechanical ventilation. Crit Care Med 32:2496-2501
39. Sreedhara A, Flengsrud R, Langsrud T, Kaul P, Prakash V, Vegarud GE (2010) Structural characteristic, pH and thermal stabilities of apo and holo forms of caprine and bovine lactoferrins. Biometals 23:1159-1170
40. Tung YT, Chen HL, Lai CW, Shen CJ, Lai YW, Chen CM (2011) Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice. Mol Nutr Food Res 55:1036-1043
41. Ward PP, Paz E, Conneely OM (2005) Multifunctional roles of lactoferrin: a critical overview. Cell Mol Life Sci 62:2540-2548
42. Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334-1349
43. Wen ST, Chen W, Chen HL, Lai CW, Yen CC, Lee KH, Wu SC, Chen CM (2013) Amniotic fluid stem cells from EGFP transgenic mice attenuate hyperoxia-induced acute lung injury. PLoS One 8:e75383
44. Xiang M, Fan J, Fan J (2010) Association of Toll-like receptor signaling and reactive oxygen species: a potential therapeutic target for posttrauma acute lung injury. Mediators Inflamm 2010:916425
45. Yang F, Coalson JJ, Bobb HH, Carter JD, Banu J, Ghio AJ (1999) Resistance of hypotransferrinemic mice to hyperoxia-induced lung injury. Am J Physiol 277:L1214-L1223
46. Yen CC, Lin CY, Chong KY, Tsai TC, Shen CJ, Lin MF, Su CY, Chen HL, Chen CM (2009) Lactoferrin as a natural regimen for selective decontamination of the digestive tract: recombinant porcine lactoferrin expressed in the milk of transgenic mice protects neonates from pathogenic challenge in the gastrointestinal tract. J Infect Dis 199:590-598
47. Yen CC, Lai YW, Chen HL, Lai CW, Lin CY, Chen W, Kuan YP, Hsu WH, Chen CM (2011a) Aerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injury. PLoS One 6:e26870
48. Yen CC, Shen CJ, Hsu WH, Chang YH, Lin HT, Chen HL, Chen CM (2011b) Lactoferrin: an iron-binding antimicrobial protein against Escherichia coli infection. Biometals 24:585-594