Recombinant porcine lactoferrin expressed in the milk of transgenic mice protects neonatal mice from a lethal challenge with enterovirus type 71

Vaccine

Volumn 26, Issue 7, 2008, Pages 891-898

  Chen, Hsiao Ling ^a   Wang, Li Chung ^b,c   Chang, Chi Hsuan ^b   Yen, Chih Ching ^b,d   Cheng, Winston T K ^e   Wu, Shinn Chih ^e   Hung, Che Ming ^b   Kuo, Meng Fu ^b   Chen, Chuan Mu ^b  

^a DA YEH UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Antiviral activity; Enterovirus 71; Neonatal viral infection; Porcine lactoferrin; Transgenic mice

Indexed keywords

ALPHA LACTALBUMIN; LACTOFERRIN; PORCINE LACTOFERRIN; RECOMBINANT LACTOFERRIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; BAGG ALBINO MOUSE; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE MODEL; ENTEROVIRUS 71; ENZYME LINKED IMMUNOSORBENT ASSAY; FEVER; HAND FOOT AND MOUTH DISEASE; HEMIZYGOTE; HOMOZYGOTE; IMMUNOHISTOCHEMISTRY; MILK; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; TAIWAN; TRANSGENIC MOUSE; VIRUS INFECTION;

ANIMALS; ANIMALS, NEWBORN; ANTIVIRAL AGENTS; BODY WEIGHT; CHILD, PRESCHOOL; DISEASE MODELS, ANIMAL; ENTEROVIRUS; ENTEROVIRUS INFECTIONS; FEMALE; HUMANS; INFANT, NEWBORN; LACTALBUMIN; LACTATION; LACTOFERRIN; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MILK; RECOMBINANT PROTEINS; SWINE;

EID: 38649115675     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.12.013     Document Type: Article

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