Prenatal exposure to phthalate esters and behavioral syndromes in children at 8 years of age: Taiwan maternal and infant cohort study

Environmental Health Perspectives

Volumn 123, Issue 1, 2015, Pages 95-100

  Lien, Yin Ju ^a,b   Ku, Hsiu Ying ^c,d   Su, Pen Hua ^e   Chen, Suh Jen ^e   Chen, Hsiao Yen ^d   Liao, Pao Chi ^f   Chen, Wei J ^b   Wang, Shu Li ^c,d  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^f NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ESTER; PHTHALIC ACID; PHTHALIC ACID DERIVATIVE;

ADULT; CHECKLIST; CHEMICALLY INDUCED; CHILD; CHILD BEHAVIOR DISORDERS; COHORT ANALYSIS; FEMALE; HUMAN; MALE; PREGNANCY; PRENATAL EXPOSURE; STATISTICAL MODEL; TAIWAN; THIRD TRIMESTER PREGNANCY; URINE;

ADULT; CHECKLIST; CHILD; CHILD BEHAVIOR DISORDERS; COHORT STUDIES; ESTERS; FEMALE; HUMANS; LINEAR MODELS; LOGISTIC MODELS; MALE; PHTHALIC ACIDS; PREGNANCY; PREGNANCY TRIMESTER, THIRD; PRENATAL EXPOSURE DELAYED EFFECTS; TAIWAN;

EID: 84920082864     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1307154     Document Type: Article

References (28)

1. Achenbach TM. 1991. Manual for the Child Behavior Checklist/4-18 and 1991 Profile. Burlington, VT:University of Vermont, Department of Psychiatry.
2. Braun JM, Smith KW, Williams PL, Calafat AM, Berry K, Ehrlich S, et al. 2012. Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy. Environ Health Perspect 120:739-745; doi:10.1289/ehp.1104139.
3. Chen ML, Chen JS, Tang CL, Mao IF. 2008. The internal exposure of Taiwanese to phthalate—an evidence of intensive use of plastic materials. Environ Int 34:79-85.
4. Chen TA, Yang WJ, Li YY, Chen X, Xu SQ. 2011. Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: inhibition of proliferation and promotion of differen-tiation in PC12 cells. Toxicol Lett 201:34-41.
5. Duty SM, Ackerman RM, Calafat AM, Hauser R. 2005. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ Health Perspect 113:1530-1535; doi:10.1289/ehp.8083.
6. Engel SM, Miodovnik A, Canfield RL, Zhu CB, Silva MJ, Calafat AM, et al. 2010. Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environ Health Perspect 118:565-571; doi:10.1289/ehp.0901470.
7. Fan RG, Portuguez MW, Nunes ML. 2013. Cognition, behavior and social competence of preterm low birth weight children at school age. Clinics (São Paulo) 68:915-921.
8. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, et al. 1999. Maternal thyroid deficiency during pregnancy and subsequent neuro-psychological development of the child. N Eng J Med 341:549-555.
9. Hernández-Díaz S, Mitchell AA, Kelley KE, Calafat AM, Hauser R. 2009. Medications as a potential source of exposure to phthalates in the U.S. population. Environ Health Perspect 117:185-189; doi:10.1289/ehp.11766.
10. Huang PC, Kuo PL, Guo YL, Liao PC, Lee CC. 2007. Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Hum Reprod 22:2715-2722.
11. Ivanova MY, Dobrean A, Dopfner M, Erol N, Fombonne E, Fonseca AC, et al. 2007. Testing the 8-syndrome structure of the child behavior checklist in 30 soci-eties. J Clin Child Adolesc Psychol 36:405-417.
12. Just AC, Adibi JJ, Rundle AG, Calafat AM, Camann DE, Hauser R, et al. 2010. Urinary and air phthalate concentrations and self-reported use of personal care products among minority pregnant women in New York city. J Expo Sci Environ Epidemiol 20:625-633.
13. Kim BN, Cho SC, Kim Y, Shin MS, Yoo HJ, Kim JW, et al. 2009. Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children. Biol Psychiatry 66:958-963.
14. Li XJ, Jiang L, Chen L, Chen HS, Li X. 2013. Neurotoxicity of dibutyl phthalate in brain development following perinatal exposure: a study in rats. Environ Toxicol Pharmacol 36:392-402.
15. Li Y, Zhuang MZ, Li T, Shi N. 2009. Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure. J Appl Toxicol 29:603-611.
16. Lin CH, Chen TJ, Chen SS, Hsiao PC, Yang RC. 2011. Activation of Trim17 by PPARγ is involved in di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells. Toxicol Lett 206:245-251.
17. Lin LC, Wang SL, Chang YC, Huang PC, Cheng JT, Su PH, et al. 2011. Associations between maternal phthalate exposure and cord sex hormones in human infants. Chemosphere 83:1192-1199.
18. Morreale de Escobar G, Obregón MJ, Escobar del Rey F. 2004. Role of thyroid hormone during early brain development. Eur J Endocrinol 151(suppl 3):U25-U37.
19. Porterfield SP, Hendrich CE. 1993. The role of thyroid hormones in prenatal and neonatal neurological development—current perspectives. Endocr Rev 14(1):94-106.
20. Raadal M, Milgrom P, Cauce AM, Mancl L. 1994. Behavior problems in 5-to 11-year-old children from low-income families. J Am Acad Child Adolesc Psychiatr 33:1017-1025.
21. Schettler T. 2006. Human exposure to phthalates via consumer products. Int J Androl 29:134-139.
22. Tanaka T. 2002. Reproductive and neurobehavioural toxicity study of bis(2-ethylhexyl) phthalate (DEHP) administered to mice in the diet. Food Chem Toxicol 40:1499-1506.
23. Tehrani-Doost M, Shahrivar Z, Pakbaz B, Rezaie A, Ahmadi F. 2011. Normative data and psychometric properties of the child behavior checklist and teacher rating form in an Iranian community sample. Iran J Pediatr 21:331-342.
24. Wang SL, Su PH, Jong SB, Guo YL, Chou WL, Päpke O. 2005. In utero exposure to dioxins and polychlorinated biphenyls and its relations to thyroid function and growth hormone in newborns. Environ Health Perspect 113:1645-1650; doi:10.1289/ehp.7994.
25. Wechsler D. 1991. Wechsler Intelligence Scale for Children-III. San Antonio, X:Psychological Corporation. Wenzel A, Franz C, Breous E, Loos U. 2005. Modulation of iodide uptake by dialkyl phthalate plasticisers in FRTL-5 rat thyroid follicular cells. Mol Cell Endocrinol 244:63-71.
26. Whyatt RM, Liu XH, Rauh VA, Calafat AM, Just AC, Hoepner L, et al. 2012. Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age. Environ Health Perspect 120:290-295; doi:10.1289/ehp.1103705.
27. Xu Y, Agrawal S, Cook TJ, Knipp GT. 2008. Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta. Placenta 29:962-969.
28. Yang HJ, Soong WT, Chang CN, Chen WJ. 2000. Competence and behavioral/emotional problems among Taiwanese adolescents as reported by parents and teachers. J Am Acad Child Adolesc Psychiatr 39:232-239.