Activation of Trim17 by PPARγ is involved in Di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells

Toxicology Letters

Volumn 206, Issue 3, 2011, Pages 245-251

  Lin, Chuang Hao ^a   Chen, Tsan Ju ^a   Chen, Shun Sheng ^c   Hsiao, Pei Chun ^a,b,c   Yang, Rei Cheng ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Apoptosis; DEHP; Developmental neurotoxicity; PPAR ; Trim17

Indexed keywords

CASPASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PROTEIN TRIM17; RING FINGER PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LINE; CONTROLLED STUDY; MOUSE; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; CELL SURVIVAL; DIETHYLHEXYL PHTHALATE; MICE; PLASTICIZERS; PPAR GAMMA;

ANIMALIA; RATTUS;

EID: 80052539261     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.08.002     Document Type: Article

References (37)

1. Akasaki Y., Liu G., Matundan H.H., Ng H., Yuan X., Zeng Z., Black K.L., Yu J.S. A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells. J. Biol. Chem. 2006, 281:6165-6174.
2. Akbar M., Baick J., Calderon F., Wen Z., Kim H.Y. Ethanol promotes neuronal apoptosis by inhibiting phosphatidylserine accumulation. J. Neurosci. Res. 2006, 83:432-440.
3. Blanco V., Lopez Camelo J., Carri N.G. Growth inhibition, morphological differentiation and stimulation of survival in neuronal cell type (Neuro-2a) treated with trophic molecules. Cell Biol. Int. 2001, 25:909-917.
4. Braissant O., Wahli W. Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development. Endocrinology 1998, 139:2748-2754.
5. Chen T., Yang W., Li Y., Chen X., Xu S. Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: inhibition of proliferation and promotion of differentiation in PC12 cells. Toxicol. Lett. 2011, 201:34-41.
6. Courchesne E., Pierce K., Schumann C.M., Redcay E., Buckwalter J.A., Kennedy D.P., Morgan J. Mapping early brain development in autism. Neuron 2007, 56:399-413.
7. Dhanya C.R., Indu A.R., Deepadevi K.V., Kurup P.A. Inhibition of membrane Na(+)-K+ Atpase of the brain, liver and RBC in rats administered di(2-ethylhexyl) phthalate (DEHP) a plasticizer used in polyvinyl chloride (PVC) blood storage bags. Indian J. Exp. Biol. 2003, 41:814-820.
8. FDA Safety Assessment of di(2-ethylhexyl) phthalate (DEHP) Released from Medical Devices 2001, Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, MD, USA.
9. Kavlock R., Boekelheide K., Chapin R., Cunningham M., Faustman E., Foster P., Golub M., Henderson R., Hinberg I., Little R., Seed J., Shea K., Tabacova S., Tyl R., Williams P., Zacharewski T. NTP center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reprod. Toxicol. 2002, 16:529-653.
10. Kim B.N., Cho S.C., Kim Y., Shin M.S., Yoo H.J., Kim J.W., Yang Y.H., Kim H.W., Bhang S.Y., Hong Y.C. Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children. Biol. Psychiatry 2009, 66:958-963.
11. Kim E.J., Park K.S., Chung S.Y., Sheen Y.Y., Moon D.C., Song Y.S., Kim K.S., Song S., Yun Y.P., Lee M.K., Oh K.W., Yoon D.Y., Hong J.T. Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. J. Pharmacol. Exp. Ther. 2003, 307:505-517.
12. Koch H.M., Preuss R., Angerer J. Di(2-ethylhexyl) phthalate (DEHP): human metabolism and internal exposure-an update and latest results. Int. J. Androl. 2006, 29:155-165. discussion 181-155.
13. Koh S.H., Jung B., Song C.W., Kim Y., Kim Y.S., Kim S.H. 15-deoxy-delta12,14-prostaglandin J2, a neuroprotectant or a neurotoxicant?. Toxicology 2005, 216:232-243.
14. Lahti J., Raikkonen K., Kajantie E., Heinonen K., Pesonen A.K., Jarvenpaa A.L., Strandberg T. Small body size at birth and behavioural symptoms of ADHD in children aged five to six years. J. Child Psychol. Psychiatry 2006, 47:1167-1174.
15. Landrigan P.J. What causes autism? Exploring the environmental contribution. Curr. Opin. Pediatr. 2010, 22:219-225.
16. Lapinskas P.J., Brown S., Leesnitzer L.M., Blanchard S., Swanson C., Cattley R.C., Corton J.C. Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver. Toxicology 2005, 207:149-163.
17. Lassot I., Robbins I., Kristiansen M., Rahmeh R., Jaudon F., Magiera M.M., Mora S., Vanhille L., Lipkin A., Pettmann B., Ham J., Desagher S. Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis. Cell Death Differ. 2010, 17:1928-1941.
18. Latini G., De Felice C., Presta G., Del Vecchio A., Paris I., Ruggieri F., Mazzeo P. In utero exposure to di-(2-ethylhexyl) phthalate and duration of human pregnancy. Environ. Health Perspect. 2003, 111:1783-1785.
19. Masuo Y., Morita M., Oka S., Ishido M. Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain. Regul. Pept. 2004, 123:225-234.
20. Moore R.W., Rudy T.A., Lin T.M., Ko K., Peterson R.E. Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer di(2-ethylhexyl) phthalate. Environ. Health Perspect. 2001, 109:229-237.
21. Moreno S., Farioli-Vecchioli S., Ceru M.P. Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS. Neuroscience 2004, 123:131-145.
22. Ogawa S., Goto W., Orimo A., Hosoi T., Ouchi Y., Muramatsu M., Inoue S. Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. Biochem. Biophys. Res. Commun. 1998, 251:515-519.
23. Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A. The tripartite motif family identifies cell compartments. EMBO J. 2001, 20:2140-2151.
24. Ryu J.Y., Whang J., Park H., Im J.Y., Kim J., Ahn M.Y., Lee J., Kim H.S., Lee B.M., Yoo S.D., Kwack S.J., Oh J.H., Park K.L., Han S.Y., Kim S.H. Di(2-ethylhexyl) phthalate induces apoptosis through peroxisome proliferators-activated receptor-gamma and ERK 1/2 activation in testis of Sprague-Dawley rats. J. Toxicol. Environ. Health A 2007, 70:1296-1303.
25. Sathyanarayana S. Phthalates and children's health. Curr. Probl. Pediatr. Adolesc. Health Care 2008, 38:34-49.
26. Schintu N., Frau L., Ibba M., Caboni P., Garau A., Carboni E., Carta A.R. PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease. Eur. J. Neurosci. 2009, 29:954-963.
27. Tanida T., Warita K., Ishihara K., Fukui S., Mitsuhashi T., Sugawara T., Tabuchi Y., Nanmori T., Qi W.M., Inamoto T., Yokoyama T., Kitagawa H., Hoshi N. Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of action: mixed exposure to phenol, phthalate, and dioxin cancels the effects of sole exposure on mouse midbrain dopaminergic nuclei. Toxicol. Lett. 2009, 189:40-47.
28. Urano T., Usui T., Takeda S., Ikeda K., Okada A., Ishida Y., Iwayanagi T., Otomo J., Ouchi Y., Inoue S. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. Biochem. Biophys. Res. Commun. 2009, 383:263-268.
29. Valentiner U., Carlsson M., Erttmann R., Hildebrandt H., Schumacher U. Ligands for the peroxisome proliferator-activated receptor-gamma have inhibitory effects on growth of human neuroblastoma cells in vitro. Toxicology 2005, 213:157-168.
30. van der Zwaag B., Franke L., Poot M., Hochstenbach R., Spierenburg H.A., Vorstman J.A.S., van Daalen E., de Jonge M.V., Verbeek N.E., Brilstra E.H., van't Slot R., Ophoff R.A., van Es M.A., Blauw H.M., Veldink J.H., Buizer-Voskamp J.E., Beemer F.A., van den Berg L.H., Wijmenga C., van Amstel H.K.P., van Engeland H., Burbach J.P.H., Staal W.G. Gene-network analysis identifies susceptibility genes related to glycobiology in autism. PLoS ONE 2009, 4:e5324.
31. Wada K., Nakajima A., Katayama K., Kudo C., Shibuya A., Kubota N., Terauchi Y., Tachibana M., Miyoshi H., Kamisaki Y., Mayumi T., Kadowaki T., Blumberg R.S. Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation. J. Biol. Chem. 2006, 281:12673-12681.
32. Wittassek M., Angerer J. Phthalates: metabolism and exposure. Int. J. Androl. 2008, 31:131-138.
33. Yi J.H., Park S.W., Brooks N., Lang B.T., Vemuganti R. PPARgamma agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms. Brain Res. 2008, 1244:164-172.
34. Yokoyama Y., Okubo T., Kano I., Sato S., Kano K. Induction of apoptosis by mono(2-ethylhexyl) phthalate (MEHP) in U937 cells. Toxicol. Lett. 2003, 144:371-381.
35. Youle R.J., Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9:47-59.
36. Zhang H.L., Xu M., Wei C., Qin A.P., Liu C.F., Hong L.Z., Zhao X.Y., Liu J., Qin Z.H. Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-kappaB signaling pathway. Neuroscience 2011, 176:381-395.
37. Zhao X., Strong R., Zhang J., Sun G., Tsien J.Z., Cui Z., Grotta J.C., Aronowski J. Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia. J. Neurosci. 2009, 29:6186-6195.