Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-κB signaling pathways

Molecular Immunology

Volumn 64, Issue 1, 2015, Pages 144-151

  Yang, Shu Fa ^a   Zhuang, Tai Feng ^a   Si, Yan Mei ^a   Qi, Ke Yan ^a   Zhao, Juan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

B cell antigen receptor (BCR); Coriolus versicolor mushroom polysaccharides (CVP); Immunopotentiating effects; Leukocytes; TLR 4

Indexed keywords

B LYMPHOCYTE RECEPTOR; BLOCKING ANTIBODY; CORIOLUS VERSICOLOR MUSHROOM POLYSACCHARIDE; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; POLYSACCHARIDE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE TRANSLOCATION; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IMMUNOREGULATION; MEDICINAL FUNGUS; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPLEEN CELL; TRAMETES VERSICOLOR; WESTERN BLOTTING; AGARICALES; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FEMALE; FLUORESCENCE; GENE REARRANGEMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOLOGY; IMMUNOMODULATION; KINETICS; LYMPHOCYTE ACTIVATION; METABOLISM; MONOCYTE; PHOSPHORYLATION; SPLEEN; T LYMPHOCYTE;

BASIDIOMYCOTA; FUNGI; MUS; TRAMETES VERSICOLOR;

AGARICALES; ANIMALS; B-LYMPHOCYTES; CELL MEMBRANE; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLUORESCENCE; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULINS; IMMUNOMODULATION; INTERLEUKIN-2; KINETICS; LYMPHOCYTE ACTIVATION; MICE, INBRED BALB C; MONOCYTES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLYSACCHARIDES; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 4;

EID: 84920063726     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2014.11.007     Document Type: Article

References (25)

1. Ando I., Tsukumo Y., Wakabayashi T., Akashi S., Miyake K., Kataoka T., Nagai K. Safflower polysaccharides activate the transcription factor NF-kappa B via Toll-like receptor 4 and induce cytokine production by macrophages. Int Immunopharmacol 2002, 2:1155-1162.
2. Bao X., Liu C., Fang J., Li X. Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst. Carbohydrate Res 2001, 332:67-74.
3. Brown G.D., Gordon S. Fungal beta-glucans and mammalian immunity. Immunity 2003, 19:311-315.
4. DeFranco, A.L., 1999. B lymphocyte activation. In Fundamental Immunology, W. Paul, Lippincott-Raven (eds.). New York, Philadelphia, pp. 225-265.
5. Fisher M., Yang L.X. Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy. Anticancer Res. 2002, 22:1737-1754.
6. Glabe C.G., Harty P.K., Rosen S.D. Preparation and properties of fluorescent polysaccharides. Anal. Biochem. 1983, 130:287-294.
7. Han S.B., Kim Y.H., Lee C.W., Park S.M., Lee H.Y., Ahn K.S., Kim I.H., Kim H.M. Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. Immunopharmacology 1998, 40:39-48.
8. Han S.B., Park S.H., Lee K.H., Lee C.W., Lee S.H., Kim H.C., Kim Y.S., Lee H.S., Kim H.M. Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells. Int. Immunopharmacol. 2001, 1:1969-1978.
9. Han S.B., Park S.K., Ahn H.J., Yoon Y.D., Kim Y.H., Lee J.J., Lee K.H., Moon J.S., Kim H.C., Kim H.M. Characterization of B cell membrane receptors of polysaccharide isolated from the root of Acanthopanax koreanum. Int. Immunopharmacol. 2003, 3:683-691.
10. Han S.B., Yoon Y.D., Ahn H.J., Lee H.S., Lee C.W., Yoon W.K., Park S.K., Kim H.M. Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus. Int. Immunopharmacol. 2003, 3:1301-1312.
11. Ho C.Y., Lau C.B., Kim C.F., Leung K.N., Fung K.P., Tse T.F., Chan H.H., Chow M.S. Differential effect of Coriolus versicolor (Yunzhi) extract on cytokine production by murine lymphocytes in vitro. Int. Immunopharmacol. 2004, 4:1549-1557.
12. Jimenez-Medina E., Berruguilla E., Romero I., Algarra I., Collado A., Garrido F., Garcia-Lora A. The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis. BMC Cancer 2008, 8:78.
13. Katoh R., Ooshiro M. Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models. Cell. Mol. Immunol. 2007, 4:295-299.
14. Kim B.C., Kim Y.S., Lee J.W., Seo J.H., Ji E.S., Lee H., Park Y.I., Kim C.J. Protective effect of coriolus versicolor cultivated in citrus extract against nitric oxide-induced apoptosis in human neuroblastoma SK-N-MC cells. Exp. Neurobiol. 2011, 20:100-109.
15. Kim H.M., Han S.B., Oh G.T., Kim Y.H., Hong D.H., Hong N.D., Yoo I.D. Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Int. J. Immunopharmacol. 1996, 18:295-303.
16. Lee C.L., Sit W.H., Jiang P.P., So I.W., Wan J.M. Polysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokine balance for suppression of activated human T cell proliferation by MAPKp38 and STAT5 pathways. J. Pharm. Pharmacol. 2008, 60:1491-1499.
17. Liu M., Li J., Kong F., Lin J., Gao Y. Induction of immunomodulating cytokines by a new polysaccharide-peptide complex from culture mycelia of Lentinus edodes. Immunopharmacology 1998, 40:187-198.
18. Netea M.G., van Deuren M., Kullberg B.J., Cavaillon J.M., Van der Meer J.W. Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?. Trends Immunol. 2002, 23:135-139.
19. Ng T.B. A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen. Pharmacol. 1998, 30:1-4.
20. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998, 282:2085-2088.
21. Sakamoto J., Morita S., Oba K., Matsui T., Kobayashi M., Nakazato H., Ohashi Y. Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials. Cancer Immunol. Immunother. CII 2006, 55:404-411.
22. Sonoda Y., Kasahara T., Mukaida N., Shimizu N., Tomoda M., Takeda T. Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng. Immunopharmacology 1998, 38:287-294.
23. Tzianabos A.O. Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function. Clin. Microbiol. Rev. 2000, 13:523-533.
24. Ueda Y., Fujimura T., Kinami S., Hirono Y., Yamaguchi A., Naitoh H., Tani T., Kaji M., Yamagishi H., Miwa K. A randomized phase III trial of postoperative adjuvant therapy with S-1 alone versus S-1 plus PSK for stage II/IIIA gastric cancer: Hokuriku-Kinki Immunochemo-Therapy Study Group-Gastric Cancer (HKIT-GC). Jpn. J. Clin. Oncol. 2006, 36:519-522.
25. Yoon Y.D., Han S.B., Kang J.S., Lee C.W., Park S.K., Lee H.S., Kim H.M. Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum. Int. Immunopharmacol. 2003, 3:1873-1882.