Safflower polysaccharides activate the transcription factor NF-κB via Toll-like receptor 4 and induce cytokine production by macrophages

International Immunopharmacology

Volumn 2, Issue 8, 2002, Pages 1155-1162

  Ando, Izuru ^a   Tsukumo, Yoshinori ^a   Wakabayashi, Tetsuya ^a   Akashi, Sachiko ^b   Miyake, Kensuke ^b   Kataoka, Takao ^a   Nagai, Kazuo ^a,c  

^a Tokyo Institute of Technology ^*  (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c CHUBU UNIVERSITY   (Japan)

Author keywords

Cytokine production; NF B; Polysaccharides; Safflower; TLR4

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NITRIC OXIDE; POLYSACCHARIDE; SAFFLOWER POLYSACCHARIDE SF1; SAFFLOWER POLYSACCHARIDE SF2; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; CYTOKINE; DROSOPHILA PROTEIN; MEMBRANE PROTEIN; PLANT EXTRACT; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGRADATION; DRUG EFFECT; DRUG PURIFICATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PETAL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; C3H MOUSE; CELL LINE; DOSE RESPONSE; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; PLANT; SAFFLOWER;

ANIMAL; CARTHAMUS TINCTORIUS; CELL LINE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMAN; MACROPHAGES, PERITONEAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; NF-KAPPA B; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; POLYSACCHARIDES; RECEPTORS, CELL SURFACE; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATORS; ANIMALS; DROSOPHILA PROTEINS; HUMANS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 0035993218     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(02)00076-0     Document Type: Article

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