-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. 2002. The protein kinase complement of the human genome. Science 298:1912-1934. http://dx.doi.org/10.1126/science.1075762.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
2
-
-
79551594605
-
Protein kinases: evolution of dynamic regulatory proteins
-
Taylor SS, Kornev AP. 2011. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci 36:65-77. http://dx.doi.org/10.1016/j.tibs.2010.09.006.
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 65-77
-
-
Taylor, S.S.1
Kornev, A.P.2
-
3
-
-
55749102720
-
A helix scaffold for the assembly of active protein kinases
-
Kornev AP, Taylor SS, Ten Eyck LF. 2008. A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A 105:14377-14382. http://dx.doi.org/10.1073/pnas.0807988105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 14377-14382
-
-
Kornev, A.P.1
Taylor, S.S.2
Ten Eyck, L.F.3
-
4
-
-
84883311219
-
Allosteric activation of functionally asymmetric RAF kinase dimers
-
Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS. 2013. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell 154:1036-1046. http://dx.doi.org/10.1016/j.cell.2013.07.046.
-
(2013)
Cell
, vol.154
, pp. 1036-1046
-
-
Hu, J.1
Stites, E.C.2
Yu, H.3
Germino, E.A.4
Meharena, H.S.5
Stork, P.J.S.6
Kornev, A.P.7
Taylor, S.S.8
Shaw, A.S.9
-
5
-
-
20444411532
-
Second nature: biological functions of the Raf-1 "kinase."
-
Baccarini M. 2005. Second nature: biological functions of the Raf-1 "kinase." FEBS Lett 579:3271-3277. http://dx.doi.org/10.1016/j.febslet.2005.03.024.
-
(2005)
FEBS Lett
, vol.579
, pp. 3271-3277
-
-
Baccarini, M.1
-
6
-
-
79960064432
-
Raf family kinases: old dogs have learned new tricks
-
Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W. 2011. Raf family kinases: old dogs have learned new tricks. Genes Cancer 2:232-260. http://dx.doi.org/10.1177/1947601911407323.
-
(2011)
Genes Cancer
, vol.2
, pp. 232-260
-
-
Matallanas, D.1
Birtwistle, M.2
Romano, D.3
Zebisch, A.4
Rauch, J.5
von Kriegsheim, A.6
Kolch, W.7
-
7
-
-
0030898415
-
The complexity of Raf-1 regulation
-
Morrison DK, Cutler RE. 1997. The complexity of Raf-1 regulation. Curr Opin Cell Biol 9:174-179. http://dx.doi.org/10.1016/S0955-0674(97)80060-9.
-
(1997)
Curr Opin Cell Biol
, vol.9
, pp. 174-179
-
-
Morrison, D.K.1
Cutler, R.E.2
-
8
-
-
1842816670
-
Signal transduction: IMPlications for Rasdependent ERK signaling
-
Ory S, Morrison DK. 2004. Signal transduction: IMPlications for Rasdependent ERK signaling. Curr Biol 14:R277-R278. http://dx.doi.org/10.1016/j.cub.2004.03.023.
-
(2004)
Curr Biol
, vol.14
, pp. R277-R278
-
-
Ory, S.1
Morrison, D.K.2
-
9
-
-
78649322633
-
Partner exchange: Protein-protein interactions in the Raf pathway
-
Wimmer R, Baccarini M. 2010. Partner exchange: Protein-protein interactions in the Raf pathway. Trends Biochem Sci 35:660-668. http://dx.doi.org/10.1016/j.tibs.2010.06.001.
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 660-668
-
-
Wimmer, R.1
Baccarini, M.2
-
10
-
-
79955044151
-
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF
-
Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS. 2011. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A 108:6067-6072. http://dx.doi.org/10.1073/pnas.1102554108.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 6067-6072
-
-
Hu, J.1
Yu, H.2
Kornev, A.P.3
Zhao, J.4
Filbert, E.L.5
Taylor, S.S.6
Shaw, A.S.7
-
11
-
-
83355168628
-
Prokino: an ontology for integrative analysis of protein kinases in cancer
-
Gosal G, Kochut KJ, Kannan N. 2011. Prokino: an ontology for integrative analysis of protein kinases in cancer. PLoS One 6:e28782. http://dx.doi.org/10.1371/journal.pone.0028782.
-
(2011)
PLoS One
, vol.6
-
-
Gosal, G.1
Kochut, K.J.2
Kannan, N.3
-
12
-
-
84901326332
-
Prediction and prioritization of rare oncogenic mutations in the cancer kinome using novel features and multiple classifiers
-
ManChon U, Talevich E, Katiyar S, Rasheed K, Kannan N. 2014. Prediction and prioritization of rare oncogenic mutations in the cancer kinome using novel features and multiple classifiers. PLoS Comput Biol 10:e1003545. http://dx.doi.org/10.1371/journal.pcbi.1003545.
-
(2014)
PLoS Comput Biol
, vol.10
-
-
ManChon, U.1
Talevich, E.2
Katiyar, S.3
Rasheed, K.4
Kannan, N.5
-
13
-
-
84862273387
-
Identification of a novel family of BRAF(V600E) inhibitors
-
Qin J, Xie P, Ventocilla C, Zhou G, Vultur A, Chen Q, Liu Q, Herlyn M, Winkler J, Marmorstein R. 2012. Identification of a novel family of BRAF(V600E) inhibitors. J Med Chem 55:5220-5230. http://dx.doi.org/10.1021/jm3004416.
-
(2012)
J Med Chem
, vol.55
, pp. 5220-5230
-
-
Qin, J.1
Xie, P.2
Ventocilla, C.3
Zhou, G.4
Vultur, A.5
Chen, Q.6
Liu, Q.7
Herlyn, M.8
Winkler, J.9
Marmorstein, R.10
-
14
-
-
0346882663
-
ModLoop: automated modeling of loops in protein structures
-
Fiser A, Sali A. 2003. ModLoop: automated modeling of loops in protein structures. Bioinformatics 19:2500-2501. http://dx.doi.org/10.1093/bioinformatics/btg362.
-
(2003)
Bioinformatics
, vol.19
, pp. 2500-2501
-
-
Fiser, A.1
Sali, A.2
-
15
-
-
58149186589
-
Pseudokinases: functional insights gleaned from structure
-
Kornev AP, Taylor SS. 2009. Pseudokinases: functional insights gleaned from structure. Structure 17:5-7. http://dx.doi.org/10.1016/j.str.2008.12.005.
-
(2009)
Structure
, vol.17
, pp. 5-7
-
-
Kornev, A.P.1
Taylor, S.S.2
-
16
-
-
0034675919
-
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
-
Zhang BH, Guan KL. 2000. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J 19:5429-5439. http://dx.doi.org/10.1093/emboj/19.20.5429.
-
(2000)
EMBO J
, vol.19
, pp. 5429-5439
-
-
Zhang, B.H.1
Guan, K.L.2
-
17
-
-
70349438995
-
A dimerization-dependent mechanism drives RAF catalytic activation
-
Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M. 2009. A dimerization-dependent mechanism drives RAF catalytic activation. Nature 461:542-545. http://dx.doi.org/10.1038/nature08314.
-
(2009)
Nature
, vol.461
, pp. 542-545
-
-
Rajakulendran, T.1
Sahmi, M.2
Lefrançois, M.3
Sicheri, F.4
Therrien, M.5
-
18
-
-
84886629236
-
Deciphering the structural basis of eukaryotic protein kinase regulation
-
Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS, Kornev AP. 2013. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol 11:e1001680. http://dx.doi.org/10.1371/journal.pbio.1001680.
-
(2013)
PLoS Biol
, vol.11
-
-
Meharena, H.S.1
Chang, P.2
Keshwani, M.M.3
Oruganty, K.4
Nene, A.K.5
Kannan, N.6
Taylor, S.S.7
Kornev, A.P.8
-
19
-
-
33644696097
-
Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome
-
Rodriguez-Viciana P, Tetsu O, Tidyman WE, Estep AL, Conger BA, Cruz MS, McCormick F, Rauen KA. 2006. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. Science 311:1287-1290. http://dx.doi.org/10.1126/science.1124642.
-
(2006)
Science
, vol.311
, pp. 1287-1290
-
-
Rodriguez-Viciana, P.1
Tetsu, O.2
Tidyman, W.E.3
Estep, A.L.4
Conger, B.A.5
Cruz, M.S.6
McCormick, F.7
Rauen, K.A.8
-
20
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JWC, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA. 2002. Mutations of the BRAF gene in human cancer. Nature 417:949-954. http://dx.doi.org/10.1038/nature00766.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmieri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.C.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
21
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan PTC, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Project CG, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R. 2004. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116:855-867. http://dx.doi.org/10.1016/S0092-8674(04)00215-6.
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.C.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
Project, C.G.7
Jones, C.M.8
Marshall, C.J.9
Springer, C.J.10
Barford, D.11
Marais, R.12
-
22
-
-
58149204174
-
Structure of the pseudokinaseVRK3reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site
-
ScheeffED, Eswaran J, Bunkoczi G, Knapp S, Manning G. 2009. Structure of the pseudokinaseVRK3reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure 17:128-138. http://dx.doi.org/10.1016/j.str.2008.10.018.
-
(2009)
Structure
, vol.17
, pp. 128-138
-
-
Scheeff, E.D.1
Eswaran, J.2
Bunkoczi, G.3
Knapp, S.4
Manning, G.5
-
23
-
-
84897540766
-
Kinases and pseudokinases: lessons learned from RAF
-
Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. 2014. Kinases and pseudokinases: lessons learned from RAF. Mol Cell Biol 34:1538-1546. http://dx.doi.org/10.1128/MCB.00057-14.
-
(2014)
Mol Cell Biol
, vol.34
, pp. 1538-1546
-
-
Shaw, A.S.1
Kornev, A.P.2
Hu, J.3
Ahuja, L.G.4
Taylor, S.S.5
-
24
-
-
79960706975
-
Aromatic-aromatic interactions in proteins: beyond the dimer
-
Lanzarotti E, Biekofsky RR, Estrin DA, Marti MA, Turjanski AG. 2011. Aromatic-aromatic interactions in proteins: beyond the dimer. J Chem Infect Model 51:1623-1633. http://dx.doi.org/10.1021/ci200062e.
-
(2011)
J Chem Infect Model
, vol.51
, pp. 1623-1633
-
-
Lanzarotti, E.1
Biekofsky, R.R.2
Estrin, D.A.3
Marti, M.A.4
Turjanski, A.G.5
-
25
-
-
0035413608
-
Dynamics of cAMP-dependent protein kinase
-
Johnson DA, Akamine P, Radzio-Andzelm E, Madhusudan M, Taylor SS. 2001. Dynamics of cAMP-dependent protein kinase. Chem Rev 101:2243-2270. http://dx.doi.org/10.1021/cr000226k.
-
(2001)
Chem Rev
, vol.101
, pp. 2243-2270
-
-
Johnson, D.A.1
Akamine, P.2
Radzio-Andzelm, E.3
Madhusudan, M.4
Taylor, S.S.5
-
26
-
-
23644439447
-
Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase
-
Iyer GH, Garrod S, Woods VL, Taylor SS. 2005. Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. J Mol Biol 351:1110-1122. http://dx.doi.org/10.1016/j.jmb.2005.06.011.
-
(2005)
J Mol Biol
, vol.351
, pp. 1110-1122
-
-
Iyer, G.H.1
Garrod, S.2
Woods, V.L.3
Taylor, S.S.4
-
27
-
-
77950482089
-
Global consequences of activation loop phosphorylation on protein kinase A
-
Steichen JM, Iyer GH, Li S, Saldanha SA, Deal MS, Woods VL, Taylor SS. 2010. Global consequences of activation loop phosphorylation on protein kinase A. J Biol Chem 285:3825-3832. http://dx.doi.org/10.1074/jbc. M109.061820.
-
(2010)
J Biol Chem
, vol.285
, pp. 3825-3832
-
-
Steichen, J.M.1
Iyer, G.H.2
Li, S.3
Saldanha, S.A.4
Deal, M.S.5
Woods, V.L.6
Taylor, S.S.7
-
28
-
-
84860369376
-
Structural basis for the regulation of protein kinase A by activation loop phosphorylation
-
Steichen JM, Kuchinskas M, Keshwani MM, Yang J, Adams JA, Taylor SS. 2012. Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem 287:14672-14680. http://dx.doi.org/10.1074/jbc. M111.335091.
-
(2012)
J Biol Chem
, vol.287
, pp. 14672-14680
-
-
Steichen, J.M.1
Kuchinskas, M.2
Keshwani, M.M.3
Yang, J.4
Adams, J.A.5
Taylor, S.S.6
-
29
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J. 2006. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 125:1137-1149. http://dx.doi.org/10.1016/j.cell.2006.05.013.
-
(2006)
Cell
, vol.125
, pp. 1137-1149
-
-
Zhang, X.1
Gureasko, J.2
Shen, K.3
Cole, P.A.4
Kuriyan, J.5
|