Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats

Physiological Research

Volumn 63, Issue 5, 2014, Pages 587-590

  Landa, V ^a   Zidek V ^a   Mlejnek, P ^a   Simakova M ^a   Silhavy J ^a   Trnovska J ^b,c   Kazdova L ^b   Pravenec, M ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^c CZECH UNIVERSITY OF LIFE SCIENCES PRAGUE   (Czech Republic)

Author keywords

Cholesterol; Spontaneously hypertensive rat; Sterol regulatory element binding protein 2; Transgenic; Triglycerides

Indexed keywords

CHOLESTEROL; GLUCOSE BLOOD LEVEL; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOENOLPYRUVATE CARBOXYKINASE 1 (SOLUBLE) PROTEIN, RAT; SIGNAL PEPTIDE; SREBF2 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL;

ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL; BLOOD; DISEASE MODEL; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; LIVER; METABOLISM; OBESITY; PATHOPHYSIOLOGY; PROMOTER REGION; SPONTANEOUSLY HYPERTENSIVE RAT; TRANSGENIC RAT;

ADIPOGENESIS; ADIPOSE TISSUE; ADIPOSITY; ANIMALS; BLOOD GLUCOSE; CHOLESTEROL; DISEASE MODELS, ANIMAL; HUMANS; HYPERTENSION; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROMOTER REGIONS, GENETIC; RATS, INBRED SHR; RATS, TRANSGENIC; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIGLYCERIDES;

EID: 84919967729     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. BROWN MS, GOLDSTEIN JL: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331-340, 1997.
2. HORTON JD, SHIMOMURA I, BROWN MS, HAMMER RE, GOLDSTEIN JL, SHIMANO H: Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest 101: 2331-2339, 1998.
3. KAZDOVÁ L, DIVIŠOVÁ J, CAHOVÁ M, MARKOVÁ I: Aging-induced impairment of insulin secretion is associated with increased islet triglyceride content in non-obese hereditary hypertriglyceridemic rats. Diabetologia 45 (Suppl 2): 228, 2002.
4. MALÍNSKÁ H, OLIYARNYK O, HUBOVÁ M, ZÍDEK V, LANDA V, SIMÁKOVÁ M, MLEJNEK P, KAZDOVÁ L, KURTZ TW, PRAVENEC M: Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis. Mol Cell Biochem 335: 119-125, 2010.
5. PRAVENEC M, KAZDOVÁ L, LANDA V, ZÍDEK V, MLEJNEK P, ŠIMÁKOVÁ M, JANSA P, FOREJT J, KŘEN V, KŘENOVÁ D, QI N, WANG JM, CHAN D, AITMAN TJ, KURTZ TW: Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat. Hypertension 51: 148-153, 2008.
6. PRAVENEC M, KŘEN V, LANDA V, MLEJNEK P, MUSILOVÁ A, ŠILHAVÝ J, ŠIMÁKOVÁ M, ZÍDEK V:Recent progress in the genetics of spontaneously hypertensive rats. Physiol Res 63 (Suppl 1): S1-S8, 2014.
7. QI NR, WANG J, ZÍDEK V, LANDA V, MLEJNEK P, KAZDOVÁ L, PRAVENEC M, KURTZ TW: A new transgenic rat model of hepatic steatosis and the metabolic syndrome. Hypertension 45: 1004-1011, 2005.
8. SHIMANO H, HORTON JD, HAMMER RE, SHIMOMURA I, BROWN MS, GOLDSTEIN JL: Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98: 1575-1584, 1996.
9. SHIMANO H, HORTON JD, SHIMOMURA I, HAMMER RE, BROWN MS, GOLDSTEIN JL: Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 99: 846-854, 1997.