Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis

Molecular and Cellular Biochemistry

Volumn 335, Issue 1-2, 2010, Pages 119-125

  Malínská, Hana ^a   Oliyarnyk, Olena ^a   Hubová, Miriam ^a   Zídek, Václav ^b   Landa, Vladimír ^b   Šimáková, Miroslava ^b   Mlejnek, Petr ^b   Kazdová, Ludmila ^a   Kurtz, Theodore W ^c   Pravenec, Michal ^b  

^a INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fatty acid composition; Hepatic steatosis; Non alcoholic steatohepatitis; Oxidative stress; SREBP 1a transgenic spontaneously hypertensive rat

Indexed keywords

ALKADIENE; ALPHA TOCOPHEROL; GAMMA TOCOPHEROL; GLUTATHIONE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; SATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

AGE DETERMINATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FATTY LIVER; GENETIC PREDISPOSITION; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; TISSUE LEVEL; TRANSGENIC RAT;

ANIMALS; FATTY ACIDS, UNSATURATED; FATTY LIVER; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIVER; OXIDATIVE STRESS; RATS; RATS, INBRED SHR; RATS, TRANSGENIC; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ANIMALIA; RATTUS;

EID: 75949129512     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0248-5     Document Type: Article

References (36)

1. JM Clark 2006 The epidemiology of nonalcoholic fatty liver disease in adults J Clin Gastroenterol 40 3 Suppl 1 S5 S10 16540768
2. RS Rector JP Thyfault Y Wei JA Ibdah 2008 Non-alcoholic fatty liver disease and the metabolic syndrome: an update World J Gastroenterol 14 185 192 10.3748/wjg.14.185 1:CAS:528:DC%2BD1cXjsFyksbY%3D 18186553 (Pubitemid 351314297)
3. TC Schreuder BJ Verwer CM van Nieuwkerk CJ Mulder 2008 Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment World J Gastroenterol 14 2474 2486 10.3748/wjg.14.2474 1:CAS:528:DC%2BD1cXptlWgs7s%3D 18442193 (Pubitemid 352037734)
4. CP Day OFW James 1998 Steatohepatitis: a tale of two ''hits''? Gastroenterology 114 842 845 10.1016/S0016-5085(98)70599-2 1:STN:280: DyaK1c3htFartQ%3D%3D 9547102 (Pubitemid 28160420)
5. S Gawrieh EC Opara TR Koch 2004 Oxidative stress in nonalcoholic fatty liver disease: pathogenesis and antioxidant therapies J Investig Med 52 506 514 1:CAS:528:DC%2BD2MXhsFaisLY%3D 15682682
6. LA Videla R Rodrigo J Araya J Poniachik 2006 Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease Trend Mol Med 12 555 558 10.1016/j.molmed.2006.10.001 1:CAS:528:DC%2BD28Xht1CqtbvL (Pubitemid 44780196)
7. IR Wanless JS Lentz 1990 Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors Hepatology 12 1106 1110 10.1002/hep.1840120505 1:STN:280:DyaK3M%2FjtlGqsQ%3D%3D 2227807
8. JP Allard E Aghdassi S Mohammed M Raman G Avand BM Arendt P Jalali T Kandasamy N Prayitno M Sherman M Guindi DW Ma JE Heathcote 2008 Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study J Hepatol 48 300 307 10.1016/j.jhep.2007.09.009 1:CAS:528:DC%2BD1cXlsF2jsw%3D%3D 18086506
9. J Araya R Rodrigo LA Videla L Thielemann M Orellana P Pettinelli J Poniachik 2004 Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease Clin Sci (Lond) 106 635 643 10.1042/CS20030326 1:CAS:528: DC%2BD2cXksFyht7Y%3D (Pubitemid 38797577)
10. CL Gentile MJ Pagliassotti 2008 The role of fatty acids in the development and progression of nonalcoholic fatty liver disease J Nutr Biochem 19 567 576 10.1016/j.jnutbio.2007.10.001 1:CAS:528:DC%2BD1cXps12isLo%3D 18430557
11. NR Qi J Wang V Zidek V Landa P Mlejnek L Kazdová M Pravenec TW Kurtz 2005 A new transgenic rat model of hepatic steatosis and the metabolic syndrome Hypertension 45 1004 1011 10.1161/01.HYP.0000161995.64192.2b 1:CAS:528:DC%2BD2MXjtlymu7g%3D 15809359 (Pubitemid 40628951)
12. A Concetti P Massei G Rotilio M Brunori EA Rachmilewitz 1976 Superoxide dismutase in red blood cells: method of assay and enzyme content in normal subjects and in patients with beta-thalassemia (major and intermedia) J Lab Clin Med 87 1057 1064 1:CAS:528:DyaE28XksValu70%3D 932520
13. H Aebi 1984 Catalase in vitro Methods Enzymol 105 121 126 10.1016/S0076-6879(84)05016-3 1:CAS:528:DyaL2cXltVKis7s%3D 6727660
14. Y Kagawa E Uchida H Yokota M Yamaguchi H Taniyama 1998 Immunohistochemical localization of apolipoprotein B-100 (ApoB-100) and expression of glutathione peroxidase (GSH-PO) in canine atherosclerotic lesions Vet Pathol 35 227 229 1:CAS:528:DyaK1cXjtFygsL0%3D 9598588
15. J Sedlak RH Lindsay 1968 Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissue with Elman's reagent Anal Biochem 25 192 205 10.1016/0003-2697(68)90092-4 1:CAS:528:DyaF1MXhslCktA%3D%3D 4973948
16. PJ Ward GO Pill JR Hatherill 1985 Systemic complement activation, lung injury and products of lipid peroxidation J Clin Invest 76 517 527 10.1172/JCI112001 1:CAS:528:DyaL2MXlsFyrsr8%3D 4031060
17. M Yokode T Kita Y Kikawa T Ogorochi S Narumiya C Kawai 1988 Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein J Clin Invest 81 720 729 10.1172/JCI113377 1:CAS:528:DyaL1cXitF2ktb4%3D 3125226
18. GL Catignani 1986 An HPLC method for the simultaneous determination of retinol and alpha-tocopherol in plasma or serum Methods Enzymol 123 215 219 10.1016/S0076-6879(86)23025-6 1:CAS:528:DyaL28XkslGisrk%3D 3702714
19. C Kiyose H Saito H Ueda O Igarashi 2001 Simultaneous determination of alpha- and gamma-tocopherol and their quinones in rats plasma and tissues using reversed-phase high performance liquid chromatography J Nutr Sci Vitaminol 47 102 107 1:CAS:528:DC%2BD3MXktlKmtb0%3D 11508699
20. J Folch M Lees GH Sloane Stanley 1957 A simple method for the isolation and purification of total lipides from animal tissues J Biol Chem 226 497 509 1:STN:280:DyaG2s%2FnsFCjtw%3D%3D 13428781
21. IH Bahcecioglu M Yalniz N IIhau H Ataseven IH Ozercan 2005 Levels of serum vitamin A, alpha-tocopherol and malondialdehyde in patients with non-alcoholic steatohepatitis: relationship with histopathologic severity Int J Clin Pract 59 318 323 10.1111/j.1742-1241.2004.00312.x 1:CAS:528: DC%2BD2MXivFWhu7w%3D 15857329 (Pubitemid 40352749)
22. IP Alwayn K Gura V Nose B Zausche P Javid J Garza J Verbesey S Voss M Ollero C Andersson B Bistrian J Folkman M Puder 2005 Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease Pediatr Res 57 445 452 10.1203/01.PDR.0000153672.43030.75 1:CAS:528:DC%2BD2MXhtl2mt7k%3D 15659701 (Pubitemid 40293615)
23. PC Calder 2007 Immunomodulation by omega-3 fatty acids Prostaglandins Leukot Essent Fatty Acids 77 327 335 10.1016/j.plefa.2007.10.015 1:CAS:528:DC%2BD2sXhsVWjtrjK 18032006 (Pubitemid 350198856)
24. MT Nakamura HP Cho SD Clarke 2000 Regulation of hepatic Δ-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice J Nutr 130 1561 1565 1:CAS:528:DC%2BD3cXjsl2huro%3D 10827210
25. G Ghafoorunissa A Ibrahim L Rajkumar V Acharya 2005 Dietary (n-3) long chain polyunsaturated fatty acids prevent sucrose-induced insulin resistance in rats J Nutr 135 2634 2638 1:CAS:528:DC%2BD2MXht1CgtrzL 16253960
26. MD Griffin TA Sanders IG Davies LM Morgan DJ Millward F Lewis S Slaughter JA Cooper GJ Miller BA Griffin 2006 Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study Am J Clin Nutr 84 1290 1298 1:CAS:528:DC%2BD28XhtlGrurvM 17158408
27. P Sjögren J Sierra-Johnson K Gertow M Rosell B Vessby U de Faire A Hamsten ML Hellenius RM Fisher 2008 Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance Diabetologia 51 328 335 10.1007/s00125-007-0876-9 18030445
28. C Comte S Bellenger J Bellenger C Tessier JP Poisson M Narce 2004 Effects of streptozotocin and dietary fructose on delta-6 desaturation in spontaneously hypertensive rat liver Biochimie 86 799 806 10.1016/j.biochi.2004.10.002 1:CAS:528:DC%2BD2cXhtVKksLbJ 15589689 (Pubitemid 39602759)
29. RR Brenner OJ Rimoldi YB Lombardo MS González AM Bernasconi A Chicco JC Basabe 2003 Desaturase activities in rat model of insulin resistance induced by a sucrose-rich diet Lipids 38 733 742 10.1007/s11745-003-1121-x 1:CAS:528:DC%2BD3sXntFCjs7Y%3D 14506836 (Pubitemid 37362265)
30. D Gasperikova E Demcakova J Ukropec I Klimes E Sebokova 2002 Insulin resistance in the hereditary hypertriglyceridemic rat is associated with an impairment of delta-6 desaturase expression in liver Ann N Y Acad Sci 967 446 453 1:CAS:528:DC%2BD38XlvVOjs7c%3D 12079873
31. B Vessby IB Gustafsson S Tengblad M Boberg A Andersson 2002 Desaturation and elongation of fatty acids and insulin action Ann N Y Acad Sci 967 183 195 1:CAS:528:DC%2BD38XlvVKqu7o%3D 12079847
32. G Perlemuter A Davit-Spraul C Cosson M Conti A Bigorgne V Paradis MP Corre L Prat V Kuoch A Basdevant G Pelletier JM Oppert C Buffet 2005 Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease Liver Int 25 946 953 10.1111/j.1478-3231.2005.01126.x 1:CAS:528:DC%2BD2MXhtFGiu7zE 16162151 (Pubitemid 41404014)
33. LA Videla R Rodrigo M Orellana V Fernandez G Tapia L Quiñones N Varela J Contreras R Lazarte A Csendes J Rojas F Maluenda P Burdiles JC Diaz G Smok L Thielemann J Poniachik 2004 Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients Clin Sci (Lond) 106 261 268 10.1042/CS20030285 1:CAS:528:DC%2BD2cXisVyrtL8%3D (Pubitemid 38365832)
34. M Koruk S Taysi MC Savas 2004 Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis Ann Clin Lab Sci 34 57 62 1:CAS:528:DC%2BD2cXislyjurs%3D 15038668
35. V Nobili A Pastore LM Gaeta G Tozzi D Comparcola MR Sartorelli M Marcellini E Bertini F Piemonte 2005 Glutathione metabolism and antioxidant enzymes in patients affected by nonalcoholic steatohepatitis Clin Chim Acta 355 105 111 10.1016/j.cccn.2004.12.022 1:CAS:528:DC%2BD2MXivFyqt7g%3D 15820484
36. A Elizondo J Araya R Rodrigo J Poniachik A Csendes F Maluenda JC Díaz C Signorini C Sgherri M Comporti LA Videla 2007 Polyunsaturated fatty acid pattern in liver and erythrocyte phospholipids from obese patients Obesity (Silver Spring) 15 24 31 10.1038/oby.2007.518 1:CAS:528: DC%2BD2sXosVeisr8%3D