The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Bjursell, Mikael ^a   Xu, Xiufeng ^a   Admyre, Therése ^a   Böttcher, Gerhard ^a   Lundin, Sofia ^a   Nilsson, Ralf ^a   Stone, Virginia M ^b   Morgan, Noel G ^b   Lam, Yan Y ^d   Storlien, Leonard H ^c   Lindén, Daniel ^a   Smith, David M ^a   Mohammad, Bohlooly Y ^a   Oscarsson, Jan ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY OF SYDNEY   (Australia)

^d PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; G PROTEIN COUPLED RECEPTOR 120; INSULIN; LARD; OMEGA 3 FATTY ACID; PALM OIL; SATURATED FATTY ACID; FATTY ACID; G PROTEIN COUPLED RECEPTOR; GLUCOSE; O3FAR1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORE TEMPERATURE; ENERGY EXPENDITURE; FAT MASS; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HISTOLOGY; IMPAIRED GLUCOSE TOLERANCE; LIPID DIET; LIPID LIVER LEVEL; LIPID METABOLISM; LOCOMOTION; MALE; MOUSE; NONHUMAN; OBESITY; WEIGHT GAIN; ANIMAL; BODY COMPOSITION; BODY WEIGHT; C57BL MOUSE; ENERGY METABOLISM; GENETICS; INTESTINE; LUNG; METABOLISM; PROCEDURES; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ANIMALS; BODY COMPOSITION; BODY WEIGHT; DIET, HIGH-FAT; ENERGY METABOLISM; FATTY ACIDS; FATTY ACIDS, OMEGA-3; GLUCOSE; INTESTINES; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OBESITY; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84919935254     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114942     Document Type: Article

References (43)

1. Sykaras AG, Demenis C, Case RM, McLaughlin JT, Smith CP (2012) Duodenal enteroendocrine I-cells contain mRNA transcripts encoding key endocannabinoid and fatty acid receptors. PLoS One 7: e42373.
2. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, et al. (2005) Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 11: 90-94.
3. Duca FA, Swartz TD, Sakar Y, Covasa M (2012) Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota. PLoS One 7: e39748.
4. Miyauchi S, Hirasawa A, Iga T, Liu N, Itsubo C, et al. (2009) Distribution and regulation of protein expression of the free fatty acid receptor GPR120. Naunyn Schmiedebergs Arch Pharmacol 379: 427-434.
5. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, et al. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142: 687-698.
6. Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, et al. (2012) Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483: 350-354.
7. Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sorhede Winzell M, et al. (2014) GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of langerhans. Diabetologia.
8. Suckow AT, Polidori D, Yan W, Chon S, Ying Ma J, et al. (2014) Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: A role for GPR120 in glucagon secretion. J Biol Chem.
9. Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, et al. (2003) The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 278: 11303-11. Epub 2002 Dec 19.
10. Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, et al. (2003) Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 422: 173-176.
11. Burns RN, Moniri NH (2010) Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. Biochem Biophys Res Commun 396: 1030-1035.
12. White PJ, Arita M, Taguchi R, Kang JX, Marette A (2010) Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice. Diabetes 59: 3066-3073.
13. Storlien LH, Kraegen EW, Chisholm DJ, Ford GL, Bruce DG, et al. (1987) Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science 237: 885-888.
14. Hulbert AJ, Turner N, Storlien LH, Else PL (2005) Dietary fats and membrane function: Implications for metabolism and disease. Biol Rev Camb Philos Soc 80: 155-169.
15. Carpentier YA, Portois L, Malaisse WJ (2006) N-3 fatty acids and the metabolic syndrome. Am J Clin Nutr 83: 1499S-1504S.
16. Bjursell M, Gerdin AK, Jonsson M, Surve VV, Svensson L, et al. (2006) G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. Biochem Biophys Res Commun 348: 359-366.
17. Bjursell M, Admyre T, Goransson M, Marley AE, Smith DM, et al. (2011) Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. Am J Physiol Endocrinol Metab 300: E211-20.
18. Gerdin AK, Surve VV, Jonsson M, Bjursell M, Bjorkman M, et al. (2006) Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice. Biochemical & Biophysical Research Communications 349: 825-832.
19. Bjursell M, Gerdin AK, Ploj K, Svensson D, Svensson L, et al. (2006) Melanin-concentrating hormone receptor 1 deficiency increases insulin sensitivity in obese leptin-deficient mice without affecting body weight. Diabetes 55: 725-733.
20. Bjursell M, Ahnmark A, Bohlooly YM, William-Olsson L, Rhedin M, et al. (2007) Opposing effects of adiponectin receptors 1 and 2 on energy metabolism. Diabetes 56: 583-93.
21. Lofgren L, Stahlman M, Forsberg GB, Saarinen S, Nilsson R, et al. (2012) The BUME method: A novel automated chloroform-free 96-well total lipid extraction method for blood plasma. J Lipid Res 53: 1690-1700.
22. Perez-Martinez P, Perez-Jimenez F, Lopez-Miranda J (2010) n-3 PUFA and lipotoxicity. Biochim Biophys Acta 1801: 362-366.
23. Mozaffarian D, Wu JH (2011) Omega-3 fatty acids and cardiovascular disease: Effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58: 2047-2067.
24. Superko HR, Superko SM, Nasir K, Agatston A, Garrett BC (2013) Omega-3 fatty acid blood levels: Clinical significance and controversy. Circulation 128: 2154-2161.
25. Huang XF, Xin X, McLennan P, Storlien L (2004) Role of fat amount and type in ameliorating diet-induced obesity: Insights at the level of hypothalamic arcuate nucleus leptin receptor, neuropeptide Y and pro-opiomelanocortin mRNA expression. Diabetes Obes Metab 6: 35-44.
26. Rossmeisl M, Jilkova ZM, Kuda O, Jelenik T, Medrikova D, et al. (2012) Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: Possible role of endocannabinoids. PLoS One 7: e38834.
27. Lamping KG, Nuno DW, Coppey LJ, Holmes AJ, Hu S, et al. (2013) Modification of high saturated fat diet with n-3 polyunsaturated fat improves glucose intolerance and vascular dysfunction. Diabetes Obes Metab 15: 144-152.
28. Kim EH, Bae JS, Hahm KB, Cha JY (2012) Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease. Biochem Pharmacol 84: 1359-1365.
29. Butler AA, Kozak LP (2010) A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes 59: 323-329.
30. Janovska P, Flachs P, Kazdova L, Kopecky J (2013) Anti-obesity effect of n-3 polyunsaturated fatty acids in mice fed high-fat diet is independent of cold-induced thermogenesis. Physiol Res 62: 153-161.
31. Pan DA, Hulbert AJ, Storlien LH (1994) Dietary fats, membrane phospholipids and obesity. J Nutr 124: 1555-1565.
32. Flachs P, Rossmeisl M, Kuda O, Kopecky J (2013) Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype. Biochim Biophys Acta 1831: 986-1003.
33. Couet C, Delarue J, Ritz P, Antoine JM, Lamisse F (1997) Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. Int J Obes Relat Metab Disord 21: 637-643.
34. Buettner R, Parhofer KG, Woenckhaus M, Wrede CE, Kunz-Schughart LA, et al. (2006) Defining high-fat-diet rat models: Metabolic and molecular effects of different fat types. J Mol Endocrinol 36: 485-501.
35. Bellenger J, Bellenger S, Bataille A, Massey KA, Nicolaou A, et al. (2011) High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: Inflammatory pathway inhibition. Diabetes 60: 1090-1099.
36. Todoric J, Loffler M, Huber J, Bilban M, Reimers M, et al. (2006) Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids. Diabetologia 49: 2109-2119.
37. Gonzalez-Periz A, Horrillo R, Ferre N, Gronert K, Dong B, et al. (2009) Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: A role for resolvins and protectins. FASEB J 23: 1946-1957.
38. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7: 947-953.
39. Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, et al. (2003) The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 112: 91-100.
40. Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, et al. (2008) Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets. Diabetes 57: 2382-2392.
41. Doetschman T (2009) Influence of genetic background on genetically engineered mouse phenotypes. Methods Mol Biol 530: 423-433.
42. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, et al. (1995) Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 269: 230-234.
43. Scacheri PC, Crabtree JS, Novotny EA, Garrett-Beal L, Chen A, et al. (2001) Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice. Genesis 30: 259-263.