High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: Inflammatory pathway inhibition

Diabetes

Volumn 60, Issue 4, 2011, Pages 1090-1099

  Bellenger, Jérôme ^a   Bellenger, Sandrine ^a   Bataille, Amandine ^b   Massey, Karen A ^c   Nicolaou, Anna ^c   Rialland, Mickaël ^a   Tessier, Christian ^a   Kang, Jing X ^d   Narce, Michel ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b Chu   (France)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; 18 HYDROXYEICOSAPENTAENOIC ACID; ARACHIDONIC ACID; CASPASE 3; CYTOKINE; GLUCOSE; GLUCOSE TRANSPORTER 2; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 1BETA; LIPOXIN A; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OMEGA 3 FATTY ACID; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CYTOKINE RELEASE; FEMALE; GLUCOSE BLOOD LEVEL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; INSULIN BLOOD LEVEL; MALE; MEDIATOR RELEASE; MOUSE; NONHUMAN; PANCREAS; PANCREAS INJURY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; CAENORHABDITIS ELEGANS PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; FATTY ACID DESATURASES; FATTY ACIDS, OMEGA-3; FEMALE; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN; LIPIDS; MALE; MICE; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 79953174254     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0901     Document Type: Article

References (51)

1. Pighin D, Karabatas L, Pastorale C, et al. Role of lipids in the early developmental stages of experimental immune diabetes induced by multiple low-dose streptozotocin. J Appl Physiol 2005;98:1064-1069 (Pubitemid 40283690)
2. Karabatas LM, Pastorale C, de Bruno LF, et al. Early manifestations in multiple-low-dose streptozotocin-induced diabetes in mice. Pancreas 2005;30:318-324 (Pubitemid 40586808)
3. Kim WH, Lee JW, Gao B, Jung MH. Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway. Cell Signal 2005;17:1516-1532 (Pubitemid 41253991)
4. Emre Y, Hurtaud C, Karaca M, Nubel T, Zavala F, Ricquier D. Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes. Proc Natl Acad Sci USA 2007;104:19085-19090
5. Makarov SS. NF-kappaB as a therapeutic target in chronic inflammation: recent advances. Mol Med Today 2000;6:441-448
6. Knip M, Veijola R, Virtanen SM, Hyöty H, Vaarala O, Akerblom HK. Environmental triggers and determinants of type 1 diabetes. Diabetes 2005;54 (Suppl. 2):S125-S136 (Pubitemid 43348458)
7. Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 2002;56:365-379 (Pubitemid 35232740)
8. Chen M, Yang ZD, Smith KM, Carter JD, Nadler JL. Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity. Diabetologia 2005;48:486-495 (Pubitemid 40487296)
9. McDuffie M, Maybee NA, Keller SR, et al. Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes 2008;57:199-208
10. Machado FS, Esper L, Dias A, et al. Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med 2008;205:1077-1086 [retracted in: J Exp Med 2009;206:2573]
11. Yacoubian S, Serhan CN. New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases. Nat Clin Pract Rheumatol 2007;3:570-579 (Pubitemid 47506014)
12. Serhan CN. Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol 2007;25:101-137 (Pubitemid 46697904)
13. De Caterina R, Madonna R, Bertolotto A, Schmidt EB. n-3 Fatty acids in the treatment of diabetic patients: biological rationale and clinical data. Diabetes Care 2007;30:1012-1026 (Pubitemid 46556605)
14. Weylandt KH, Kang JX. Rethinking lipid mediators. Lancet 2005;366:618-620 (Pubitemid 41176007)
15. Endres S, Ghorbani R, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265-271 (Pubitemid 19045549)
16. Calder PC. N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 2003;38:343-352 (Pubitemid 36724290)
17. De Caterina R, Madonna R, Massaro M. Effects of omega-3 fatty acids on cytokines and adhesion molecules. Curr Atheroscler Rep 2004;6:485-491 (Pubitemid 39585674)
18. Jolly CA, Jiang YH, Chapkin RS, McMurray DN. Dietary (n-3) polyunsaturated fatty acids suppress murine lymphoproliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide. J Nutr 1997;127:37-43 (Pubitemid 27069013)
19. Suresh Y, Das UN. Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. Nutrition 2003;19:213-228 (Pubitemid 36279459)
20. Arita M, Bianchini F, Aliberti J, et al. Stereochemical assignment, anti-inflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med 2005;201:713-722 (Pubitemid 40395117)
21. Hudert CA, Weylandt KH, Lu Y, et al. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci USA 2006;103:11276-11281 (Pubitemid 44156509)
22. Masoodi M, Mir AA, Petasis NA, Serhan CN, Nicolaou A. Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom 2008;22:75-83 (Pubitemid 351156118)
23. Wei D, Li J, Shen M, et al. Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic b-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. Diabetes 2010;59:471-478
24. Kang JX, Wang J, Wu L, Kang ZB. Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature 2004;427:504 (Pubitemid 38209102)
25. Leiter EH. Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: influence of inbred background, sex, and thymus. Proc Natl Acad Sci USA 1982;79:630-634 (Pubitemid 12137765)
26. Friesen NT, Büchau AS, Schott-Ohly P, Lgssiar A, Gleichmann H. Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin. Diabetologia 2004;47:676-685 (Pubitemid 38658370)
27. Narce M, Ausdrubal P, Delachambre MC, Gresti J, Poisson JP. Influence of spontaneous hypertension on n-3 delta-6-desaturase activity and fatty acid composition of rat hepatocytes. Mol Cell Biochem 1995;152:7-12
28. Narce M, Asdrubal P, Delachambre MC, Véricel E, Lagarde M, Poisson JP. Age-related changes in linoleic acid bioconversion by isolated hepatocytes from spontaneously hypertensive and normotensive rats. Mol Cell Biochem 1994;141:9-13
29. Bellenger J, Bellenger S, Clément L, et al. A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension. FASEB J 2004;18:773-775
30. Sailaja Devi MM, Das UN. Effect of prostaglandins against alloxan-induced diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids 2006;74:39-60 (Pubitemid 41773067)
31. Kleemann R, Scott FW, Wörz-Pagenstert U, Nimal Ratnayake WM, Kolb H. Impact of dietary fat on Th1/Th2 cytokine gene expression in the pancreas and gut of diabetes-prone BB rats. J Autoimmun 1998;11:97-103 (Pubitemid 28080732)
32. Linn T, Noke M, Woehrle M, et al. Fish oil-enriched diet and reduction of low-dose streptozocin-induced hyperglycemia. Inhibition of macrophage activation. Diabetes 1989;38:1402-1411 (Pubitemid 19271722)
33. Schnedl WJ, Ferber S, Johnson JH, Newgard CB. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes 1994;43:1326-1333
34. Thulesen J, Orskov C, Holst JJ, Poulsen SS. Short-term insulin treatment prevents the diabetogenic action of streptozotocin in rats. Endocrinology 1997;138:62-68 (Pubitemid 27009406)
35. Wang Z, Gleichmann H. GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice. Diabetes 1998;47:50-56 (Pubitemid 28030807)
36. Rabinovitch A, Suarez-Pinzon WL. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol 1998;55:1139-1149 (Pubitemid 28206701)
37. Eldor R, Yeffet A, Baum K, et al. Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents. Proc Natl Acad Sci USA 2006;103:5072-5077
38. Bhattacharya A, Chandrasekar B, Rahman MM, Banu J, Kang JX, Fernandes G. Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet. Biochem Biophys Res Commun 2006;349:925-930 (Pubitemid 44380189)
39. Nowak J, Weylandt KH, Habbel P, et al. Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis 2007;28:1991-1995 (Pubitemid 47500613)
40. Lamhamedi-Cherradi SE, Zheng S, Tisch RM, Chen YH. Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes. Diabetes 2003;52:2274-2278 (Pubitemid 37059497)
41. Holstad M, Sandler S. A transcriptional inhibitor of TNF-alpha prevents diabetes induced by multiple low-dose streptozotocin injections in mice. J Autoimmun 2001;16:441-447 (Pubitemid 32579006)
42. Cailleau C, Diu-Hercend A, Ruuth E, Westwood R, Carnaud C. Treatment with neutralizing antibodies specific for IL-1b prevents cyclophosphamide-induced diabetes in nonobese diabetic mice. Diabetes 1997;46:937-940 (Pubitemid 27220991)
43. Babcock TA, Helton WS, Hong D, Espat NJ. Omega-3 fatty acid lipid emulsion reduces LPS-stimulated macrophage TNF-alpha production. Surg Infect (Larchmt) 2002;3:145-149
44. Weylandt KH, Nadolny A, Kahlke L, et al. Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis. Biochim Biophys Acta 2008;1782:634-641
45. Schmöcker C, Weylandt KH, Kahlke L, et al. Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines. Hepatology 2007;45:864-869 (Pubitemid 46631554)
46. Viedt C, Orth SR. Monocyte chemoattractant protein-1 (MCP-1) in the kidney: does it more than simply attract monocytes? Nephrol Dial Transplant 2002;17:2043-2047
47. Eizirik DL, Pavlovic D. Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM? Diabetes Metab Rev 1997;13:293-307
48. Razzak A, Aldrich C, Babcock TA, Saied A, Espat NJ. Attenuation of iNOS in an LPS-stimulated macrophage model by omega-3 fatty acids is independent of COX-2 derived PGE2. J Surg Res 2008;145:244-250
49. Bleich D, Chen S, Zipser B, Sun D, Funk CD, Nadler JL. Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. J Clin Invest 1999;103:1431-1436 (Pubitemid 29535499)
50. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC. Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem 2002;277:10912-10921 (Pubitemid 34952846)
51. Maderna P, Godson C. Lipoxins: resolutionary road. Br J Pharmacol 2009;158:947-959