Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect

Angewandte Chemie - International Edition

Volumn 50, Issue 12, 2011, Pages 2795-2798

  Gu, Liangcai ^a,d   Eisman, Eli B ^a   Dutta, Somnath ^b   Franzmann, Titus M ^b   Walter, Stefan ^b   Gerwick, William H ^c   Skiniotis, Georgios ^b   Sherman, David H ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

acyl carrier protein; biosynthesis; curacin A; enzymes; polyketide synthases

Indexed keywords

ACYL CARRIER PROTEINS; BIOCHEMICAL STUDIES; BIOSYNTHETIC PATHWAY; CATALYTIC EFFICIENCIES; CURACIN A; EFFICIENT STRATEGY; MULTI-STEP; POLYKETIDE SYNTHASES; SYNERGISTIC EFFECT;

BIOCHEMISTRY; CATALYSTS; ENZYMES;

BIOSYNTHESIS;

ACYL CARRIER PROTEIN; CURACIN A; CYCLOPROPANE DERIVATIVE; MULTIENZYME COMPLEX; POLYKETIDE SYNTHASE; THIAZOLE DERIVATIVE;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; GENETICS; METABOLISM; MULTIGENE FAMILY;

ACYL CARRIER PROTEIN; BIOSYNTHETIC PATHWAYS; CYCLOPROPANES; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; POLYKETIDE SYNTHASES; THIAZOLES;

EID: 79952517819     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201005280     Document Type: Article

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