A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Kon, Shigeyuki ^a   Nakayama, Yosuke ^a   Matsumoto, Naoki ^a   Ito, Koyu ^a   Kanayama, Masashi ^a   Kimura, Chiemi ^a   Kouro, Hitomi ^a   Ashitomi, Dai ^a   Matsuda, Tadashi ^a   Uede, Toshimitsu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA9BETA1 INTEGRIN; GLYCOPROTEIN; LEUCYLARGINYLSERYLLYSYLARGINYLSERYLPHENYLALANYLGLUTAMINYLVALYLSERYLASPARTYLGLUTAMYLGLUTAMINYLTYROSINE; MATRILYSIN; OSTEOPONTIN; POLYPEPTIDE; STROMELYSIN; UNCLASSIFIED DRUG; ANTIBODY; COLLAGEN TYPE 2; INTEGRIN; INTEGRIN ALPHA 9 BETA 1; LIGAND; PEPTIDE; PROTEIN BINDING;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISEASE MODEL; EXPERIMENTAL ARTHRITIS; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; TYPE II COLLAGEN ANTIBODY INDUCED ARTHRITIS; 3T3 CELL LINE; AMINO ACID SEQUENCE; ANIMAL; ARTHRITIS, EXPERIMENTAL; CELL MOTION; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; EXPERIMENTAL MELANOMA; HAMSTER; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; WOUND HEALING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ARTHRITIS, EXPERIMENTAL; CELL MOVEMENT; CHO CELLS; COLLAGEN TYPE II; CRICETINAE; CRICETULUS; INTEGRINS; LIGANDS; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 7; MELANOMA, EXPERIMENTAL; MICE; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; OSTEOPONTIN; PEPTIDES; PROTEIN BINDING; WOUND HEALING;

EID: 84919933289     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116210     Document Type: Article

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