Functionalized tetrahydro-1 H-pyrido[4,3-b]indoles: A novel chemotype with Sirtuin 2 inhibitory activity

European Journal of Medicinal Chemistry

Volumn 92, Issue , 2015, Pages 145-155

  Yang, Tianming ^a   Chen, Xiao ^a   Jin, Hai Xiao ^b   Sethi, Gautam ^c   Go, Mei Lin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; Growth inhibition; Molecular docking Hyperacetylation of p53 and a tubulin; Sirtuin 2 inhibition; Tetrahydropyridoindoles

Indexed keywords

8 (4' (METHYLSULFONYL)PHENYL) 5 N OCTYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE; 8 BROMO 5 N OCTYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOLE; ALPHA TUBULIN; ETHYL 8 BROMO 3,4 DIHYDRO 1H PYRIDO[4,3 B]INDOLE 2(5H)CARBOXYLATE; ETHYL 8 BROMO 5 N OCTYL 3,4 DIHYDRO 1H PYRIDO[4,3 B]INDOLE 2(5H)CARBOXYLATE; INDOLE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN P53; SIRTUIN 1; SIRTUIN 2; UNCLASSIFIED DRUG; PYRIDINE DERIVATIVE; SIRT2 PROTEIN, HUMAN; TETRAHYDRO-1H-PYRIDO(3,4-B)INDOLE;

ARTICLE; BINDING AFFINITY; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; LIGHT SCATTERING; MOLECULAR DOCKING; PROTEIN ACETYLATION; PROTEIN INTERACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; SIRTUIN 2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84919928680     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.12.027     Document Type: Article

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