Jinlida granule inhibits palmitic acid induced-intracellular lipid accumulation and enhances autophagy in NIT-1 pancreatic β cells through AMPK activation

Journal of Ethnopharmacology

Volumn 161, Issue , 2015, Pages 99-107

  Wang, Dingkun ^a   Tian, Min ^a   Qi, Yuan ^a   Chen, Guang ^a   Xu, Lijun ^a   Zou, Xin ^a   Wang, Kaifu ^a   Dong, Hui ^a,b   Lu, Fuer ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Shijiazhuang Yiling Pharmaceutical Co Ltd   (China)

Author keywords

AMP activatedproteinkinase; Autophagy; Jinlida granule; Lipid metabolism; NIT 1cells; Type 2diabetes

Indexed keywords

FAT DROPLET; HERBACEOUS AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; JINLIDA GRANULE; LIPID; MESSENGER RNA; PALMITIC ACID; PHOSPHO AMP ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN; PIOGLITAZONE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; JINLIDA;

ACETYL COA CARBOXYLASE GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CARNITINE ACYLTRANSFERASE 1 GENE; COLORIMETRY; CONTROLLED STUDY; DOWN REGULATION; DRUG GRANULE; ELECTRON MICROSCOPE; ENZYME PHOSPHORYLATION; ETHNOPHARMACOLOGY; FAT CONTENT; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY ACID SYNTHASE GENE; GENE; GENE EXPRESSION; INTRACELLULAR SIGNALING; LIGHT CHAIN 3 GENE; LIPID STORAGE; MALE; MAMMAL TARGET OF RAPAMYCIN GENE; MICROTUBULE ASSOCIATED PROTEIN 1 GENE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STAINING; STEROL REGULATING ELEMENT BINDING PROTEIN 1C GENE; TRANSMISSION ELECTRON MICROSCOPY; TUBEROUS SCLEROSIS COMPLEX 1 GENE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL LINE; DRUG EFFECTS; LIPID METABOLISM; METABOLISM; MOUSE; SPRAGUE DAWLEY RAT;

MAMMALIA;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; CELL LINE; DRUGS, CHINESE HERBAL; INSULIN-SECRETING CELLS; LIPID METABOLISM; MALE; MICE; PALMITIC ACID; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

EID: 84919916243     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.12.005     Document Type: Article

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