Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria

Biochemical and Biophysical Research Communications

Volumn 456, Issue 2, 2015, Pages 670-675

  Gotoh, Yusuke ^a   Kita, Satomi ^a   Fujii, Makoto ^a   Tagashira, Hideaki ^a   Horie, Ichiro ^a   Arai, Yuji ^b   Uchida, Shinichi ^c   Iwamoto, Takahiro ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Genetic knockout; Hypercalciuria; Natriuresis; NCX inhibitors; NCX isoforms

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 2 [4 (2,5 DIFLUOROBENZYLOXY)PHENOXY] 5 ETHOXYANILINE; PROTEIN INHIBITOR; SODIUM CALCIUM EXCHANGE INHIBITOR; SODIUM CALCIUM EXCHANGE PROTEIN; TRICHLORMETHIAZIDE; UNCLASSIFIED DRUG; YM 244769; 2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; ANILINE DERIVATIVE; DIPHENYL ETHER DERIVATIVE; ISOPROTEIN; N-(3-AMINOBENZYL)-6-(4-((3-FLUOROBENZYL)OXY)PHENOXY)NICOTINAMIDE; NICOTINAMIDE; SLC8A2 PROTEIN, MOUSE; THIOUREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; ELECTROLYTE EXCRETION; HYPERCALCIURIA; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; KNOCKOUT GENE; MALE; MEMBRANE POTENTIAL; MOUSE; NATRIURESIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REAL TIME POLYMERASE CHAIN REACTION; SODIUM CALCIUM EXCHANGE; URINALYSIS; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; GENE INACTIVATION; GENETICS; KIDNEY; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

MUS;

ANILINE COMPOUNDS; ANIMALS; GENE KNOCKOUT TECHNIQUES; HYPERCALCIURIA; KIDNEY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NATRIURESIS; NIACINAMIDE; PHENYL ETHERS; PROTEIN ISOFORMS; SODIUM-CALCIUM EXCHANGER; THIOUREA;

EID: 84919883336     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.12.016     Document Type: Article

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