Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice

Endocrinology

Volumn 151, Issue 4, 2010, Pages 1829-1836

  Yang, Sung Sen ^a   Hsu, Yu Juei ^a   Chiga, Motoko ^b   Rai, Tatemitsu ^b   Sasaki, Sei ^b   Uchida, Shinichi ^b   Lin, Shih Hua ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALBINDIN; CALCITRIOL; CALCIUM CHANNEL; CALCIUM ION; CARRIER PROTEIN; CREATININE; PARATHYROID HORMONE; PROTEIN KINASE WNK4; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; SODIUM PROTON EXCHANGE PROTEIN; SODIUM TRANSPORTER; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HORMONE BLOOD LEVEL; HYPERCALCIURIA; MOUSE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOHYPOALDOSTERONISM; PSEUDOHYPOALDOSTERONISM TYPE II; VITAMIN BLOOD LEVEL;

ANIMALS; BLOTTING, WESTERN; CALCIFEDIOL; CALCIUM CHANNELS; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CREATININE; FLUORESCENT ANTIBODY TECHNIQUE; HYPERCALCIURIA; ION TRANSPORT; MICE; MICE, TRANSGENIC; NEPHRONS; PARATHYROID HORMONE; PROTEIN-SERINE-THREONINE KINASES; PSEUDOHYPOALDOSTERONISM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM-HYDROGEN ANTIPORTER; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; TRPV CATION CHANNELS;

EID: 77950280626     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0951     Document Type: Article

References (31)

1. Schambelan M, Sebastian A, Rector Jr FC 1981 Mineralocorticoidresistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption. Kidney Int 19:716-727
2. Gordon RD 1986 Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate. Hypertension 8:93-102
3. Wilson FH, Disse-Nicodème S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP 2001 Human hypertension caused by mutations in WNK kinases. Science 293:1107-1112
4. Mayan H, Vered I, Mouallem M, Tzadok-Witkon M, Pauzner R, Farfel Z 2002 Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab 87:3248-3254
5. Bindels RJ 1993 Calcium handling by the mammalian kidney. J Exp Biol 184:89-104
6. Friedman PA, Gesek FA 1993 Calcium transport in renal epithelial cells. Am J Physiol 264:F181-F198
7. Hoenderop JG, Nilius B, Bindels RJ 2005 Calcium absorption across epithelia. Physiol Rev 85:373-422
8. Jiang Y, Ferguson WB, Peng JB 2007 WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. Am J Physiol Renal Physiol 292:F545-F554
9. Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S 2007 Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab 5:331-344
10. Lee CT, Shang S, Lai LW, Yong KC, Lien YH 2004 Effect of thiazide on renal gene expression of apical calcium channels and calbindins. Am J Physiol Renal Physiol 287:F1164-F1170
11. Lee CT, Chen HC, Lai LW, Yong KC, Lien YH 2007 Effects of furosemide on renal calcium handling. Am J Physiol Renal Physiol 293:F1231-F1237
12. Lehen'kyi V, Beck B, Polakowska R, Charveron M, Bordat P, Skryma R, Prevarskaya N 2007 TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes. J Biol Chem 282:22582-22591
13. Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson-Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP 2006 Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet 38:1124-1132
14. Mayan H, Munter G, Shaharabany M, Mouallem M, Pauzner R, Holtzman EJ, Farfel Z 2004 Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation. J Clin Endocrinol Metab 89:4025-4030
15. Nijenhuis T, Renkema KY, Hoenderop JG, Bindels RJ 2006 Acidbase status determines the renal expression of Ca2+ and Mg2+ transport proteins. J Am Soc Nephrol 17:617-626
16. de Groot T, Lee K, Langeslag M, Xi Q, Jalink K, Bindels RJ, Hoenderop JG 2009 Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation. J Am Soc Nephrol 20:1693-1704
17. Mayan H, Melnikov S, Novikov I, Holtzman EJ, Farfel Z 2009 Familial hyperkalemia and hypertension: pathogenetic insights based on lithium clearance. J Clin Endocrinol Metab 94:3010-3016
18. Thomsen K, Shirley DG 2006 A hypothesis linking sodium and lithium reabsorption in the distal nephron. Nephrol Dial Transplant 21:869-880
19. Massry SG, Coburn JW, Chapman LW, Kleeman CR 1968 Role of serum Ca, parathyroid hormone, and Na Cl infusion on renal Ca and Na clearances. Am J Physiol 214:1403-1409
20. Agus ZS, Chiu PJ, Goldberg M 1977 Regulation of urinary calcium excretion in the rat. Am J Physiol 232:F545-F549
21. Yang LE, Sandberg MB, Can AD, Pihakaski-Maunsbach K, McDonough AA 2008 Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status. Am J Physiol Renal Physiol 295:F1003-F1016
22. O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW 2006 Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. J Am Soc Nephrol 17:2402-2413
23. Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S 2009 Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet 18:3978-3986
24. Noblins M, Kleinknecht D, Dommergues JP, Nazaret C, Garay RP, Jullien M, Guillot M, Fries D, Charpentier B 1992 [Liddlesyndrome(or pseudo- hyperaldosteronism). Long-term development and erythrocyte potassium flow study in 4 cases]. Arch Fr Pediatr 49:685-691
25. Caralps A 1971 [Hypercalciuria in primary aldosteronism]. Rev Clin Esp 120:437-442
26. Moudgil A, Rodich G, Jordan SC, Kamil ES 2000 Nephrocalcinosis and renal cysts associated with apparent mineralocorticoid excess syndrome. Pediatr Nephrol 15:60-62
27. Simon DB, Karet FE, Hamdan JM, DiPietro A, Sanjad SA, Lifton RP 1996 Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NK CC2. Nat Genet 13:183-188
28. Achard JM, Warnock DG, Disse-Nicodème S, Fiquet-Kempf B, Corvol P, Fournier A, Jeunemaitre X 2003 Familial hyperkalemic hypertension: phenotypic analysis in a large family with the WNK1 deletion mutation. Am J Med 114:495-498
29. Disse-Nicodème S, Achard JM, Desitter I, Houot AM, Fournier A, Corvol P, Jeunemaitre X 2000 A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension. Am J Hum Genet 67:302-310
30. Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH 2005 WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci USA 102:10315-10320
31. Huang CL, Yang SS, Lin SH 2008 Mechanism of regulation of renal ion transport by WNK kinases. Curr Opin Nephrol Hypertens 17: 519-525