Gender-specific research for emergency diagnosis and management of ischemic heart disease: Proceedings from the 2014 academic emergency medicine consensus conference cardiovascular research workgroup

Academic Emergency Medicine

Volumn 21, Issue 12, 2014, Pages 1350-1360

  Safdar, Basmah ^a   Nagurney, John T ^b   Anise, Ayodola ^h   Devon, Holli A ⁱ   D'Onofrio, Gail ^a   Hess, Erik P ^c   Hollander, Judd E ^k   Legato, Mariane J ^j   McGregor, Alyson J ^d,e   Scott, Jane ^l   Tewelde, Semhar ^f   Diercks, Deborah B ^g  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c MAYO CLINIC   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e BROWN UNIVERSITY   (United States)

^f UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h Outcomes Research Institute   (United States)

ⁱ UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^j Columbia University ^*  (United States)

^k NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^l NONE

more..

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CREATINE KINASE; DALTEPARIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; HEPARIN; TROPONIN T; BIOLOGICAL MARKER;

CARDIAC IMAGING; CARDIOVASCULAR RISK; CLINICAL FEATURE; CONFERENCE PAPER; CORONARY ARTERY DISSECTION; EMERGENCY CARE; EMERGENCY MEDICINE; HUMAN; ISCHEMIC HEART DISEASE; LABORATORY DIAGNOSIS; META ANALYSIS (TOPIC); OUTCOME ASSESSMENT; OUTCOMES RESEARCH; RISK ASSESSMENT; RISK MANAGEMENT; SEX DIFFERENCE; SYSTEMATIC REVIEW (TOPIC); TAKOTSUBO CARDIOMYOPATHY; TREATMENT OUTCOME; CORONARY ARTERY DISEASE; DISEASE MANAGEMENT; FEMALE; GENDER IDENTITY; MALE; MYOCARDIAL ISCHEMIA; ORGANIZATION AND MANAGEMENT; PATHOPHYSIOLOGY; PROGNOSIS; RESEARCH; RISK FACTOR; SEXUAL DEVELOPMENT;

BIOLOGICAL MARKERS; CORONARY ARTERY DISEASE; DISEASE MANAGEMENT; EMERGENCY MEDICINE; FEMALE; GENDER IDENTITY; HUMANS; MALE; MYOCARDIAL ISCHEMIA; PROGNOSIS; RESEARCH; RISK FACTORS; SEX CHARACTERISTICS; SEX FACTORS;

EID: 84919883120     PISSN: 10696563     EISSN: 15532712     Source Type: Journal    
DOI: 10.1111/acem.12527     Document Type: Conference Paper

References (76)

1. Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation 2013; 127: e6-245.
2. Lloyd-Jones D, Adams RJ, Brown TM, et al. Executive summary: heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 2010; 121: 948-54.
3. Mieres JH, Shaw LJ, Arai A, et al. Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervention, American Heart Association. Circulation 2005; 111: 682-96.
4. Huxley RR, Woodward M,. Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies. Lancet 2011; 378: 1297-305.
5. Almdal T, Scharling H, Jensen JS, Vestergaard H,. The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up. Arch Intern Med 2004; 164: 1422-6.
6. Safdar B, Greenberg MR,. Conference on gender-specific research in emergency care: an executive summary. Acad Emerg Med 2014; 21: 1307-17.
7. Canto JG, Shlipak MG, Rogers WJ, et al. Prevalence, clinical characteristics, and mortality among patients with myocardial infarction presenting without chest pain. JAMA 2000; 283: 3223-9.
8. Nguyen HL, Gore JM, Saczynski JS, et al. Age and sex differences and twenty-year trends (1986 to 2005) in prehospital delay in patients hospitalized with acute myocardial infarction. Circ Cardiovasc Qual Outcomes 2010; 3: 590-8.
9. Canto JG, Rogers WJ, Goldberg RJ, et al. Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality. JAMA 2012; 307: 813-22.
10. Safstrom K, Lindahl B, Swahn E,. Risk stratification in unstable coronary artery disease-exercise test and troponin T from a gender perspective. FRISC-Study Group. Fragmin during InStability in Coronary artery disease. J Am Coll Cardiol 2000; 35: 1791-800.
11. Apple FS, Quist HE, Doyle PJ, Otto AP, Murakami MM,. Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations. Clin Chem 2003; 49: 1331-6.
12. McConnell JP, Branum EL, Ballman KV, Lagerstedt SA, Katzmann JA, Jaffe AS,. Gender differences in C-reactive protein concentrations-confirmation with two sensitive methods. Clin Chem Lab Med 2002; 40: 56-9.
13. Wang TJ, Larson MG, Levy D, et al. Impact of age and sex on plasma natriuretic peptide levels in healthy adults. Am J Cardiol 2002; 90: 254-8.
14. Wiviott SD, Cannon CP, Morrow DA, et al. Differential expression of cardiac biomarkers by gender in patients with unstable angina/non-ST-elevation myocardial infarction: a TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis In Myocardial Infarction 18) substudy. Circulation 2004; 109: 580-6.
15. Fox KA, Poole-Wilson PA, Henderson RA, et al. Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial. Randomized Intervention Trial of unstable Angina. Lancet 2002; 360: 743-51.
16. Elsaesser A, Hamm CW,. Acute coronary syndrome: the risk of being female. Circulation 2004; 109: 565-7.
17. Mills N, Shah AS, Griffith M, et al. High-STEACS: high-sensitivity cardiac troponin and the under diagnosis of myocardial infarction in women. Paper presented at: European Society of Cardiology, Amsterdam, Netherlands, September 4, 2013.
18. Roger VL, Jacobsen SJ, Pellikka PA, Miller TD, Bailey KR, Gersh BJ,. Gender differences in use of stress testing and coronary heart disease mortality: a population-based study in Olmsted County, Minnesota. J Am Coll Card 1998; 32: 345-52.
19. Hess EP, Perry JJ, Calder LA, et al. Sex differences in clinical presentation, management and outcome in emergency department patients with chest pain. CJEM 2010; 12: 405-13.
20. Chang AM, Mumma B, Sease KL, Robey JL, Shofer FS, Hollander JE,. Gender bias in cardiovascular testing persists after adjustment for presenting characteristics and cardiac risk. Acad Emerg Med 2007; 14: 599-605.
21. Golden KE, Chang AM, Hollander JE,. Sex preferences in cardiovascular testing: the contribution of the patient-physician discussion. Acad Emerg Med 2013; 20: 680-8.
22. Kohli P, Gulati M,. Exercise stress testing in women: going back to the basics. Circulation 2010; 122: 2570-80.
23. Redberg RF, Cannon RO 3rd, Bairey Merz N, et al. Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: Section 2: stable ischemia: pathophysiology and gender differences. Circulation 2004; 109: e47-9.
24. Diercks DB, Mumma BE, Frank Peacock W, et al. Incremental value of objective cardiac testing in addition to physician impression and serial contemporary troponin measurements in women. Acad Emerg Med 2013; 20: 265-70.
25. Hollander JE, Chang AM, Shofer FS, et al. One-year outcomes following coronary computerized tomographic angiography for evaluation of emergency department patients with potential acute coronary syndrome. Acad Emerg Med 2009; 16: 693-8.
26. Truong QA, Hayden D, Woodard PK, et al. Sex differences in the effectiveness of early coronary computed tomographic angiography compared with standard emergency department evaluation for acute chest pain: the rule-out myocardial infarction with Computer-Assisted Tomography (ROMICAT)-II Trial. Circulation 2013; 127: 2494-502.
27. Ashurst JV, Cherney AR, Evans EM, et al. Research priorities for the influence of gender on diagnostic imaging choices in the emergency department setting. Acad Emerg Med 2014; 21: 1431-37.
28. Rogg J, Hoffmann U, Truong Q, Brown DF, Parry B, Nagurney JT,. Evaluation of renal function tests by age and sex to determine emergency department patients' eligibility for cardiac computed tomography. J Emerg Med 2013; 45: 220-7.
29. von Mering GO, Arant CB, Wessel TR, et al. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation 2004; 109: 722-5.
30. Yiu KH, de Graaf FR, Schuijf JD, et al. Age- and gender-specific differences in the prognostic value of CT coronary angiography. Heart 2012; 98: 232-7.
31. Kern MJ, Lerman A, Bech JW, et al. Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. Circulation 2006; 114: 1321-41.
32. Ng MK, Yeung AC, Fearon WF,. Invasive assessment of the coronary microcirculation: superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve. Circulation 2006; 113: 2054-61.
33. Gulati M,. Shaw LJ, Bairey Merz CN. Myocardial ischemia in women: lessons from the NHLBI WISE study. Clin Cardiol 2012; 35: 141-8.
34. Safdar B, Lichtman JH, D'Onofrio G,. Sex and the CT: an evolving story of the heart. Acad Emerg Med 2012; 19: 197-200.
35. Hess EP, Agarwal D, Chandra S, et al. Diagnostic accuracy of the TIMI risk score in patients with chest pain in the emergency department: a meta-analysis. CMAJ 2010; 182: 1039-44.
36. Fox KA, Dabbous OH, Goldberg RJ, et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ 2006; 333: 1091.
37. Backus BE, Six AJ, Kelder JC, et al. A prospective validation of the HEART score for chest pain patients at the emergency department. Int J Cardiol 2013; 168: 2153-8.
38. Christenson J, Innes G, McKnight D, et al. A clinical prediction rule for early discharge of patients with chest pain. Ann Emerg Med 2006; 47: 1-10.
39. Mitchell AM, Garvey JL, Chandra A, Diercks D, Pollack CV, Kline JA,. Prospective multicenter study of quantitative pretest probability assessment to exclude acute coronary syndrome for patients evaluated in emergency department chest pain units. Ann Emerg Med 2006; 47: 438-47.
40. Than M, Flaws D, Sanders S, et al. Development and validation of the Emergency Department Assessment of Chest pain Score and 2 h accelerated diagnostic protocol. Emerg Med Australas 2014; 26: 34-44.
41. Than M, Cullen L, Aldous S, et al. 2-hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial. J Am Coll Cardiol 2012; 59: 2091-8.
42. Mahler SA, Miller CD, Hollander JE, et al. Identifying patients for early discharge: performance of decision rules among patients with acute chest pain. Int J Cardiol 2013; 168: 795-802.
43. Jalili M, Hejripour Z, Honarmand AR, Pourtabatabaei N,. Validation of the Vancouver Chest Pain Rule: a prospective cohort study. Acad Emerg Med 2012; 19: 837-42.
44. Kline JA, Zeitouni RA, Hernandez-Nino J, Jones AE,. Randomized trial of computerized quantitative pretest probability in low-risk chest pain patients: effect on safety and resource use. Ann Emerg Med 2009; 53: 727-35.
45. Kline JA, Jones AE, Shapiro NI, et al. Multicenter, randomized trial of quantitative pretest probability to reduce unnecessary medical radiation exposure in emergency department patients with chest pain and dyspnea. Circ Cardiovasc Imag 2014; 7: 66-73.
46. Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. The Bypass Angioplasty Revascularization Investigation (BARI) Investigators. N Engl J Med 1996; 335: 217-25.
47. Min JK, Dunning A, Lin FY, et al. Age- and sex-related differences in all-cause mortality risk based on coronary computed tomography angiography findings results from the International Multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: an International Multicenter Registry) of 23,854 patients without known coronary artery disease. J Am Coll Cardiol 2011; 58: 849-60.
48. Gulati M, Cooper-DeHoff RM, McClure C, et al. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project. Arch Intern Med 2009; 169: 843-50.
49. Prinzmetal M, Kennamer R, Merliss R, Wada T, Bor N,. Angina pectoris. I. A variant form of angina pectoris; preliminary report. Am J Med 1959; 27: 375-388.
50. Beltrame JF, Limaye SB, Horowitz JD,. The coronary slow flow phenomenon-a new coronary microvascular disorder. Cardiology 2002; 97: 197-202.
51. Cannon RO 3rd, Epstein SE,. "Microvascular angina" as a cause of chest pain with angiographically normal coronary arteries. Am J Cardiol 1988; 61: 1338-43.
52. Mohri M, Koyanagi M, Egashira K, et al. Angina pectoris caused by coronary microvascular spasm. Lancet 1998; 351: 1165-9.
53. Arbogast R, Bourassa MG,. Myocardial function during atrial pacing in patients with angina pectoris and normal coronary arteriograms. Comparison with patients having significant coronary artery disease. Am J Cardiol 1973; 32: 257-63.
54. Di Fiore DP, Beltrame JF,. Chest pain in patients with 'normal angiography': could it be cardiac? Int J Evid Based Healthc 2013; 11: 56-68.
55. Wei J, Mehta PK, Johnson BD, et al. Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study. JACC Cardiovasc Interv 2012; 5: 646-53.
56. Nef HM, Mollmann H, Kostin S, et al. Tako-Tsubo cardiomyopathy: intraindividual structural analysis in the acute phase and after functional recovery. Eur Heart J 2007; 28: 2456-64.
57. Kurisu S, Inoue I, Kawagoe T, et al. Presentation of Tako-tsubo cardiomyopathy in men and women. Clin Cardiol 2010; 33: 42-45.
58. Samuelov-Kinori L, Kinori M, Kogan Y, et al. Takotsubo cardiomyopathy and QT interval prolongation: who are the patients at risk for torsades de pointes? J Electrocardiol 2009; 42: 353-7.
59. Schneider B, Athanasiadis A, Sechtem U,. Gender-related differences in takotsubo cardiomyopathy. Heart Fail Clin 2013; 9: 137-46.
60. Maturana MA, Irigoyen MC, Spritzer PM,. Menopause, estrogens, and endothelial dysfunction: current concepts. Clinics 2007; 62: 77-86.
61. Nef HM, Mollmann H, Weber M, et al. Release pattern of cardiac biomarkers in left ventricular apical ballooning. Int J Cardiol 2007; 115: 128-9.
62. Tweet MS, Hayes SN, Pitta SR, et al. Clinical features, management, and prognosis of spontaneous coronary artery dissection. Circulation 2012; 126: 579-88.
63. Rosengren A, Wallentin L,. K Gitt A, Behar S, Battler A, Hasdai D. Sex, age, and clinical presentation of acute coronary syndromes. Eur Heart J 2004; 25: 663-70.
64. Alfredsson J, Stenestrand U, Wallentin L, Swahn E,. Gender differences in management and outcome in non-ST-elevation acute coronary syndrome. Heart 2007; 93: 1357-62.
65. Hamm CW, Bassand JP, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2011; 32: 2999-3054.
66. Hvelplund A, Galatius S, Madsen M, et al. Women with acute coronary syndrome are less invasively examined and subsequently less treated than men. Eur Heart J 2010; 31: 684-90.
67. Blomkalns AL, Chen AY, Hochman JS, et al. Gender disparities in the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: large-scale observations from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the American College of Cardiology/American Heart Association Guidelines) National Quality Improvement Initiative. J Am Coll Cardiol 2005; 45: 832-7.
68. Sandhu H, Adams A, Singleton L, Clark-Carter D, Kidd J,. The impact of gender dyads on doctor-patient communication: a systematic review. Patient Educ Couns 2009; 76: 348-55.
69. Wyatt K, Branda ME, Inselman J, et al. The impact of patient-clinician dyad pairs on shared decision making outcomes: a participant-level meta-analysis. BMC Med Informat Decis Mak 2014; 14: 81.
70. Mumma BE, Baumann BM, Diercks DB, et al. Sex bias in cardiovascular testing: the contribution of patient preference. Ann Emerg Med 2011; 57: 551-60.
71. Hollander JE, Blomkalns AL, Brogan GX, et al. Standardized reporting guidelines for studies evaluating risk stratification of emergency department patients with potential acute coronary syndromes. Ann Emerg Med 2004; 44: 589-98.
72. Lerman A, Sopko G,. Women and cardiovascular heart disease: clinical implications from the Women's Ischemia Syndrome Evaluation (WISE) Study. Are we smarter? J Am Coll Cardiol 2006; 47 (3 Suppl): S59-62.
73. Hemingway H, McCallum A, Shipley M, Manderbacka K, Martikainen P, Keskimaki I,. Incidence and prognostic implications of stable angina pectoris among women and men. JAMA 2006; 295: 1404-11.
74. Shaw LJ, Bairey Merz CN, Pepine CJ, et al. Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part I: gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies. J Am Coll Cardiol 2006; 47 (3 Suppl): S4-20.
75. Reis SE, Holubkov R, Conrad Smith AJ, et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J 2001; 141: 735-41.
76. Shaw LJ, Merz CN, Pepine CJ, et al. The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation. Circulation 2006; 114: 894-904.