2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: The ADAPT trial

Journal of the American College of Cardiology

Volumn 59, Issue 23, 2012, Pages 2091-2098

  Than, Martin ^a,b   Cullen, Louise ^c,d   Aldous, Sally ^a   Parsonage, William A ^c,e   Reid, Christopher M ^f   Greenslade, Jaimi ^c,e   Flaws, Dylan ^e   Hammett, Christopher J ^c   Beam, Daren M ^g   Ardagh, Michael W ^b   Troughton, Richard ^a,b   Brown, Anthony F T ^c,e   George, Peter ^a   Florkowski, Christopher M ^a   Kline, Jeffrey A ^g   Peacock, W Frank ^h   Maisel, Alan S ⁱ   Lim, Swee Han ^j   Lamanna, Arvin ^c   Richards, A Mark ^b  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f MONASH UNIVERSITY   (Australia)

^g CAROLINAS MEDICAL CENTER   (United States)

^h LERNER RESEARCH INSTITUTE   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j SINGAPORE GENERAL HOSPITAL   (Singapore)

more..

Author keywords

acute coronary syndromes; acute myocardial infarction; emergency department; sensitivity and specificity; troponins

Indexed keywords

TROPONIN I;

ACCELERATED DIAGNOSTIC PROTOCOL; ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADULT; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROCARDIOGRAPHY; FALSE NEGATIVE RESULT; FEMALE; FOLLOW UP; HOSPITAL DISCHARGE; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; THORAX PAIN; THROMBOLYSIS IN MYOCARDIAL INFARCTION SCORE; VALIDATION STUDY;

ACUTE CORONARY SYNDROME; BIOLOGICAL MARKERS; CHEST PAIN; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC TESTS, ROUTINE; ELECTROCARDIOGRAPHY; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; MALE; MIDDLE AGED; NEW ZEALAND; PROSPECTIVE STUDIES; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TROPONIN T;

EID: 84861607690     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.02.035     Document Type: Article

References (23)

1. S. Goodacre, E. Cross, J. Arnold, K. Angelini, S. Capewell, J. Nicholl The health care burden of acute chest pain Heart 91 2005 229 230
2. C.V. Pollack Jr., F.D. Sites, F.S. Shofer, K.L. Sease, J.E. Hollander Application of the TIMI risk score for unstable angina and non-ST elevation acute coronary syndrome to an unselected emergency department chest pain population Acad Emerg Med 13 2006 13 18
3. M. Chase, J.L. Robey, K.E. Zogby, K.L. Sease, F.S. Shofer, J.E. Hollander Prospective validation of the Thrombolysis in Myocardial Infarction Risk Score in the emergency department chest pain population Ann Emerg Med 48 2006 252 259
4. J.E. Hollander The continuing search to identify the very-low-risk chest pain patient Acad Emerg Med 6 1999 979 981
5. S.L. Bernstein, D. Aronsky, R. Duseja The effect of emergency department crowding on clinically oriented outcomes Acad Emerg Med 16 2009 1 10
6. C.V. Pollack Jr., E.M. Antman, J.E. Hollander 2007 focused update to the ACC/AHA guidelines for the management of patients with ST-segment elevation myocardial infarction: implications for emergency department practice Ann Emerg Med 52 2008 344 355
7. E.A. Amsterdam, J.D. Kirk, D.A. Bluemke Testing of low-risk patients presenting to the emergency department with chest pain: a scientific statement from the American Heart Association Circulation 122 2010 1756 1776
8. K. Thygesen, J.S. Alpert, H.D. White Universal definition of myocardial infarction Circulation 116 2007 2634 2653
9. J.L. Anderson, C.D. Adams, E.M. Antman ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction J Am Coll Cardiol 50 2007 652 726
10. C.N. Aroney, H.L. Dunlevie, J.H. Bett Use of an accelerated chest pain assessment protocol in patients at intermediate risk of adverse cardiac events Med J Aust 178 2003 370 374
11. M. Than, L. Cullen, C.M. Reid A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study Lancet 377 2011 1077 1084
12. S.W. Goodacre, M. Bradburn, E. Cross, P. Collinson, A. Gray, A.S. Hall The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department Heart 97 2011 190 196
13. E. Lee-Lewandrowski, J.L. Januzzi Jr., R. Grisson, A.A. Mohammed, G. Lewandrowski, K. Lewandrowski Evaluation of first-draw whole blood, point-of-care cardiac markers in the context of the universal definition of myocardial infarction: a comparison of a multimarker panel to troponin alone and to testing in the central laboratory Arch Pathol Lab Med 135 2011 459 463
14. R.V. Luepker, F.S. Apple, R.H. Christenson Case definitions for acute coronary heart disease in epidemiology and clinical research studies Circulation 108 2003 2543 2549
15. L. Cullen, M. Than, A.F. Brown Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia Emerg Med Australas 22 2010 35 55
16. E.M. Antman, M. Cohen, P.J. Bernink The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making JAMA 284 2000 835 842
17. J.E. Hollander, A.L. Blomkalns, G.X. Brogan Standardized reporting guidelines for studies evaluating risk stratification of ED patients with potential acute coronary syndromes Acad Emerg Med 11 2004 1331 1340
18. C.P. Cannon, A. Battler, R.G. Brindis American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes J Am Coll Cardiol 38 2001 2114 2130
19. R.S. Forest, F.S. Shofer, K.L. Sease, J.E. Hollander Assessment of the standardized reporting guidelines ECG classification system: the presenting ECG predicts 30-day outcomes Ann Emerg Med 44 2004 206 212
20. S.R. Pitts, R.W. Niska, J. Xu National Hospital Ambulatory Medical Care Survey: 2006 Emergency Department Summary: Division of Health Care Statistics 2008 http://www.cdc.gov/nchs/data/nhsr/nhsr007.pdf 2010 Accessed November 12
21. R. Body, S. Carley, G. McDowell Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay J Am Coll Cardiol 58 2011 1332 1339
22. T. Reichlin, W. Hochholzer, C. Stelzig Incremental value of copeptin for rapid rule out of acute myocardial infarction J Am Coll Cardiol 54 2009 60 68
23. H.A. Valle, L.G. Riesgo, M.S. Bel, F.E. Gonzalo, M.S. Sanchez, L.I. Oliva Clinical assessment of heart-type fatty acid binding protein in early diagnosis of acute coronary syndrome Eur J Emerg Med 15 2008 140 144