Myocardial ischemia in women: Lessons from the NHLBI WISE study

Clinical Cardiology

Volumn 35, Issue 3, 2012, Pages 141-148

  Gulati, Martha ^a   Shaw, Leslee J ^b   Bairey Merz, C Noel ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b EMORY UNIVERSITY   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CYSTATIN C; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMIPRAMINE; STATIN; TROPONIN I;

ACUTE CORONARY SYNDROME; ANGIOCARDIOGRAPHY; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RISK; CAUSE OF DEATH; CLINICAL FEATURE; CORONARY ARTERY DISEASE; CORONARY ARTERY RECANALIZATION; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; EXERCISE; EXERCISE TEST; HEART CATHETERIZATION; HUMAN; ISCHEMIC HEART DISEASE; MICROANGIOPATHY; MORTALITY; OVARY INSUFFICIENCY; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PREVALENCE; PROGNOSIS; REVIEW; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; ST SEGMENT DEPRESSION; SYMPTOM; UNITED STATES; WOMEN'S HEALTH;

FEMALE; HUMANS; MALE; MYOCARDIAL ISCHEMIA; PREVALENCE; PROGNOSIS; RISK FACTORS; SEX FACTORS; WOMEN'S HEALTH;

EID: 84858033396     PISSN: 01609289     EISSN: 19328737     Source Type: Journal    
DOI: 10.1002/clc.21966     Document Type: Review

References (113)

1. Kochaneck KD, Xu J, Murphy SL, et al. Deaths: preliminary data for 2009. Natl Vital Stat Rep. 2011; 59: 1-51.
2. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics 2011 update: a report from the American Heart Association. Circulation. 2011; 123: e18-e209.
3. Ford ES, Capewell S., Coronary heart disease mortality among young adults in the U.S. from 1980 through 2002: concealed leveling of mortality rates. J Am Coll Cardiol. 2007; 50: 2128-2132. (Pubitemid 350117339)
4. Moriel M, Rozanski A, Klein J, et al. The limited efficacy of exercise radionuclide ventriculography in assessing prognosis of women with coronary artery disease. Am J Cardiol. 1995; 76: 1030-1035.
5. Bairey Merz CN, Shaw LJ, Reis SE, et al. WISE Investigators. Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part II: gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease. J Am Coll Cardiol. 2006; 47 (3 suppl): S21-S29.
6. Shaw LJ, Bairey Merz CN, Pepine CJ, et al. WISE Investigators. Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part I: gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies. J Am Coll Cardiol. 2006; 47 (3 suppl): S4-S20.
7. Shaw LJ, Shaw RE, Merz CN, et al. Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology-National Cardiovascular Data Registry. Circulation. 2008; 117: 1787-1801. (Pubitemid 351507467)
8. Smilowitz NR, Sampson BA, Abrecht CR, et al. Women have less severe and extensive coronary atherosclerosis in fatal cases of ischemic heart disease: an autopsy study. Am Heart J. 2011; 161: 681-688.
9. Von Mering GO, Arant CB, Wessel TR, et al. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation. 2004; 109: 722-725. (Pubitemid 38222890)
10. Wong TY, Klein R, Sharrett AR, et al. Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. JAMA. 2002; 287: 1153-1159. (Pubitemid 34252085)
11. Burke AP, Farb A, Malcom GT, et al. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation. 1998; 97: 2110-2116. (Pubitemid 28262117)
12. Burke AP, Virmani R, Galis Z, et al. 34th Bethesda Conference: Task force #2 What is the pathologic basis for new atherosclerosis imaging techniques [published correction appears in J Am Coll Cardiol. 2003;42:1147]? J Am Coll Cardiol. 2003; 41: 1874-1886.
13. Reynolds HR, Srichai MB, Iqbal SN, et al. Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease. Circulation. 2011; 124: 1414-1425.
14. Shaw LJ, Bugiardini R, Merz CN., Women and ischemic heart disease: evolving knowledge. J Am Coll Cardiol. 2009; 54: 1561-1575.
15. Ni H, Coady S, Rosamond W, et al. Trends from 1987 to 2004 in sudden death due to coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. Am Heart J. 2009; 157: 46-52.
16. Daly C, Clemens F, Lopez Sendon JL, et al. Gender differences in the management and clinical outcome of stable angina. Circulation. 2006; 113: 490-498.
17. Olson MB, Kelsey SF, Matthews K, et al. Symptoms, myocardial ischaemia and quality of life in women: results from the NHLBI-sponsored WISE Study. Eur Heart J. 2003; 24: 1506-1514. (Pubitemid 37010581)
18. Johnson BD, Shaw LJ, Pepine CJ, et al. Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study. Eur Heart J. 2006; 27: 1408-1415.
19. Shaw LJ, Merz CN, Pepine CJ, et al. The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation. Circulation. 2006; 114: 894-904. (Pubitemid 44337132)
20. Hemingway H, Crook AM, Feder G, et al. Underuse of coronary revascularization procedures in patients considered appropriate candidates for revascularization. N Engl J Med. 2001; 344: 645-654. (Pubitemid 32183581)
21. Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003; 289: 76-79. (Pubitemid 36026281)
22. Lerner DJ, Kannel WB., Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986; 111: 383-390. (Pubitemid 16107280)
23. Hokanson JE, Austin MA., Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk. 1996; 3: 213-219. (Pubitemid 26266496)
24. Reuterwall C, Hallqvist J, Ahlbom A, et al. the SHEEP Study Group. Higher relative, but lower absolute risks of myocardial infarction in women than in men: analysis of some major risk factors in the SHEEP study. J Intern Med. 1999; 246: 161-174. (Pubitemid 29378921)
25. Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006; 295: 1549-1555.
26. McTigue K, Larson JC, Valoski A, et al. Mortality and cardiac and vascular outcomes in extremely obese women. JAMA. 2006; 296: 79-86.
27. Spencer EA, Pirie KL, Stevens RJ, et al. Diabetes and modifiable risk factors for cardiovascular disease: the prospective Million Women Study. Eur J Epidemiol. 2008; 23: 793-799.
28. Barrett-Connor EL, Cohn BA, Wingard DL, et al. Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study. JAMA. 1991; 265: 627-631.
29. Kanaya AM, Grady D, Barrett-Connor E., Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus: a meta-analysis. Arch Intern Med. 2002; 162: 1737-1745.
30. Jayachandran M, Litwiller RD, Lahr BD, et al. Alterations in platelet function and cell-derived microvesicles in recently menopausal women: relationship to metabolic syndrome and atherogenic risk. J Cardiovasc Transl Res. 2011; 4: 811-822.
31. Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002; 288: 2709-2716. (Pubitemid 35403784)
32. Ford ES, Giles WH, Dietz WH., Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002; 287: 356-359. (Pubitemid 34251969)
33. Ramos RG, Olden K., The prevalence of metabolic syndrome among US women of childbearing age. Am J Public Health. 2008; 98: 1122-1127. (Pubitemid 351793394)
34. Gami AS, Witt BJ, Howard DE, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol. 2007; 49: 403-414. (Pubitemid 46135879)
35. Lloyd-Jones DM, Leip EP, Larson MG, et al. Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation. 2006; 113: 791-798.
36. Daviglus ML, Stamler J, Pirzada A, et al. Favorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality. JAMA. 2004; 292: 1588-1592. (Pubitemid 39314965)
37. Pasternak RC, Abrams J, Greenland P, et al. 34th Bethesda Conference: Task force #1 Identification of coronary heart disease risk: is there a detection gap? J Am Coll Cardiol. 2003; 41: 1863-1874.
38. Lakoski SG, Greenland P, Wong ND, et al. Coronary artery calcium scores and risk for cardiovascular events in women classified as "low risk" based on Framingham risk score: the multi-ethnic study of atherosclerosis (MESA). Arch Intern Med. 2007; 167: 2437-2442. (Pubitemid 350254902)
39. Michos ED, Nasir K, Braunstein JB, et al. Framingham risk equation underestimates subclinical atherosclerosis risk in asymptomatic women. Atherosclerosis. 2006; 184: 201-206. (Pubitemid 41721089)
40. Ridker PM, Rifai N, Cook NR, et al. Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA. 2005; 294: 326-333. (Pubitemid 41043776)
41. Wong ND, Pio J, Valencia R, et al. Distribution of C-reactive protein and its relation to risk factors and coronary heart disease risk estimation in the National Health and Nutrition Examination Survey (NHANES) III. Prev Cardiol. 2001; 4: 109-114. (Pubitemid 32613801)
42. Bessant R, Hingorani A, Patel L, et al. Risk of coronary heart disease and stroke in a large British cohort of patients with systemic lupus erythematosus. Rheumatology (Oxford). 2004; 43: 924-929. (Pubitemid 38996970)
43. Karim R, Stanczyk FZ, Hodis HN, et al. Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women. Menopause. 2010; 17: 785-790.
44. Ridker PM, Buring JE, Cook NR, et al. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation. 2003; 107: 391-397.
45. Wenger NK., The Reynolds Risk Score: improved accuracy for cardiovascular risk prediction in women? Nat Clin Pract Cardiovasc Med. 2007; 4: 366-367. (Pubitemid 47023441)
46. Zethelius B, Berglund L, Sundström J, et al. Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med. 2008; 358: 2107-2116. (Pubitemid 351679597)
47. Bairey Merz CN, Johnson BD, Sharaf BL, et al. Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol. 2003; 41: 413-419. (Pubitemid 36164495)
48. Shaw LJ, Bairey Merz CN, Azziz R, et al. Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation. J Clin Endocrinol Metab. 2008; 93: 1276-1284. (Pubitemid 351519721)
49. Bellamy L, Casas JP, Hingorani AD, et al. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ. 2007; 335: 974.
50. Ratner RE., Prevention of type 2 diabetes in women with previous gestational diabetes. Diabetes Care. 2007; 30 (suppl 2): S242-S245. (Pubitemid 47036432)
51. Jones LW, Haykowsky MJ, Swartz JJ, et al. Early breast cancer therapy and cardiovascular injury. J Am Coll Cardiol. 2007; 50: 1435-1441. (Pubitemid 47494586)
52. Douglas PS, Ginsburg GS., The evaluation of chest pain in women. N Engl J Med. 1996; 334: 1311-1315. (Pubitemid 126621808)
53. Hemingway H, Langenberg C, Damant J, et al. Prevalence of angina in women versus men: a systematic review and meta-analysis of international variations across 31 countries. Circulation. 2008; 117: 1526-1536. (Pubitemid 351440641)
54. Canto JG, Goldberg RJ, Hand MM, et al. Symptom presentation of women with acute coronary syndromes: myth vs reality. Arch Intern Med. 2007: 2405-2413. (Pubitemid 350258446)
55. Diamond GA, Forrester JS., Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. N Engl J Med. 1979; 300: 1350-1358. (Pubitemid 9198112)
56. Sharaf BL, Pepine CJ, Kerensky RA, et al. Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory). Am J Cardiol. 2001; 87: 937-941; A3. (Pubitemid 32299974)
57. Kennedy JW, Killip T, Fisher LD, et al. The clinical spectrum of coronary artery disease and its surgical and medical management, 1974-1979: the Coronary Artery Surgery study. Circulation. 1982; 66 (5 part 2): III16-III23.
58. Gulati M, Cooper-DeHoff RM, McClure C, et al. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project. Arch Intern Med. 2009; 169: 843-850.
59. Hochman JS, McCabe CH, Stone PH, et al. TIMI Investigators. Outcome and profile of women and men presenting with acute coronary syndromes: a report from TIMI IIIB. Thrombolysis in Myocardial Infarction. J Am Coll Cardiol. 1997; 30: 141-148. (Pubitemid 27357139)
60. Hochman JS, Tamis JE, Thompson TD, et al. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes IIb Investigators. Sex, clinical presentation, and outcome in patients with acute coronary syndromes. N Engl J Med. 1999; 341: 226-232.
61. Vaccarino V, Parsons L, Every NR, et al. Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. N Engl J Med. 1999; 341: 217-225. (Pubitemid 29334519)
62. Humphries KH, Pu A, Gao M, et al. Angina with "normal" coronary arteries: sex differences in outcomes. Am Heart J. 2008; 155: 375-381.
63. Reynolds HR, Farkouh ME, Lincoff AM, et al. Impact of female sex on death and bleeding after fibrinolytic treatment of myocardial infarction in GUSTO V. Arch Intern Med. 2007; 167: 2054-2060. (Pubitemid 350041621)
64. Blomkalns AL, Chen AY, Hochman JS, et al. Gender disparities in the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: large-scale observations from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the American College of Cardiology/American Heart Association Guidelines) National Quality Improvement Initiative. J Am Coll Cardiol. 2005; 45: 832-837. (Pubitemid 40347306)
65. Hemingway H, McCallum A, Shipley M, et al. Incidence and prognostic implications of stable angina pectoris among women and men. JAMA. 2006; 295: 1404-1411.
66. Kwok Y, Kim C, Grady D, et al. Meta-analysis of exercise testing to detect coronary artery disease in women. Am J Cardiol. 1999; 83: 660-666. (Pubitemid 29116372)
67. Kohli P, Gulati M., Exercise stress testing in women: going back to the basics. Circulation. 2010; 122: 2570-2580.
68. Shaw LJ, Peterson ED, Shaw LK, et al. Use of a prognostic treadmill score in identifying diagnostic coronary disease subgroups. Circulation. 1998; 98: 1622-1630. (Pubitemid 28500384)
69. Alexander KP, Shaw LJ, Shaw LK, et al. Value of exercise treadmill testing in women. J Am Coll Cardiol. 1998; 32: 1657-1664. (Pubitemid 28545205)
70. Gulati M, Black HR, Shaw LJ, et al. The prognostic value of a nomogram for exercise capacity in women. N Engl J Med. 2005; 353: 468-475. (Pubitemid 41127291)
71. Kavanagh T, Mertens DJ, Hamm LF, et al. Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation. J Am Coll Cardiol. 2003; 42: 2139-2143. (Pubitemid 37549899)
72. Mieres JH, Shaw LJ, Arai A, et al. Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervention, American Heart Association. Circulation. 2005; 111: 682-696. (Pubitemid 40216498)
73. Marwick TH, Shaw LJ, Lauer MS, et al. The noninvasive prediction of cardiac mortality in men and women with known or suspected coronary artery disease. Economics of Noninvasive Diagnosis (END) Study Group. Am J Med. 1999; 106: 172-178. (Pubitemid 29115957)
74. Shaw LJ, Iskandrian AE., Prognostic value of gated myocardial perfusion SPECT. J Nucl Cardiol. 2004; 11: 171-185. (Pubitemid 38949912)
75. Johnson BD, Shaw LJ, Buchthal SD, et al. Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation. 2004; 109: 2993-2999. (Pubitemid 38808322)
76. Panting JR, Gatehouse PD, Yang GZ, et al. Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging. N Engl J Med. 2002; 346: 1948-1953. (Pubitemid 34651354)
77. Pilz G, Klos M, Ali E, et al. Angiographic correlations of patients with small vessel disease diagnosed by adenosine-stress cardiac magnetic resonance imaging. J Cardiovasc Magn Reson. 2008; 10: 8.
78. Vermeltfoort IA, Bondarenko O, Raijmakers PG, et al. Is subendocardial ischaemia present in patients with chest pain and normal coronary angiograms? A cardiovascular MR study. Eur Heart J. 2007; 28: 1554-1558. (Pubitemid 47227114)
79. Raman SV, Dickerson JA, Jekic M, et al. Real-time cine and myocardial perfusion with treadmill exercise stress cardiovascular magnetic resonance in patients referred for stress SPECT. J Cardiovasc Magn Reson. 2010; 12: 41.
80. Prinzmetal M, Kennamer R, Merliss R, et al. Angina pectoris. I. A variant form of angina pectoris; preliminary report. Am J Med. 1959; 27: 375-388.
81. Sun H, Mohri M, Shimokawa H, et al. Coronary microvascular spasm causes myocardial ischemia in patients with vasospastic angina. J Am Coll Cardiol. 2002; 39: 847-851. (Pubitemid 34185333)
82. McGeechan K, Liew G, Macaskill P, et al. Meta-analysis: retinal vessel caliber and risk for coronary heart disease. Ann Intern Med. 2009; 151: 404-413.
83. Reis SE, Holubkov R, Conrad Smith AJ, et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J. 2001; 141: 735-741. (Pubitemid 32378481)
84. Han SH, Bae JH, Holmes DR Jr, et al. Sex differences in atheroma burden and endothelial function in patients with early coronary atherosclerosis. Eur Heart J. 2008; 29: 1359-1369. (Pubitemid 351806481)
85. Roman MJ, Naqvi TZ, Gardin JM, et al. Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification: a report from the American Society of Echocardiography and the Society for Vascular Medicine and Biology. Vasc Med. 2006; 11: 201-211. (Pubitemid 46099266)
86. Colacurci N, Manzella D, Fornaro F, et al. Endothelial function and menopause: effects of raloxifene administration. J Clin Endocrinol Metab. 2003; 88: 2135-2140. (Pubitemid 36549889)
87. Modena MG, Bonetti L, Coppi F, et al. Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women. J Am Coll Cardiol. 2002; 40: 505-510. (Pubitemid 34833167)
88. Lerman A, Zeiher AM., Endothelial function: cardiac events. Circulation. 2005; 111: 363-368. (Pubitemid 40165345)
89. Bugiardini R, Bairey Merz CN., Angina with "normal" coronary arteries: a changing philosophy. JAMA. 2005; 293: 477-484.
90. Alexander KP, Chen AY, Newby LK, et al. Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines) initiative. Circulation. 2006; 114: 1380-1387. (Pubitemid 44462663)
91. Jneid H, Fonarow GC, Cannon CP, et al. Sex differences in medical care and early death after acute myocardial infarction. Circulation. 2008; 118: 2803-2810.
92. Novack V, Cutlip DE, Jotkowitz A, et al. Reduction in sex-based mortality difference with implementation of new cardiology guidelines. Am J Med. 2008; 121: 597-603e1.
93. O'Donoghue M, Boden WE, Braunwald E, et al. Early invasive vs conservative treatment strategies in women and men with unstable angina and non-ST-segment elevation myocardial infarction: a meta-analysis. JAMA. 2008; 300: 71-80. (Pubitemid 351920406)
94. Lansky AJ., Outcomes of percutaneous and surgical revascularization in women. Prog Cardiovasc Dis. 2004; 46: 305-319. (Pubitemid 38201293)
95. Antman EM, Morrow DA, McCabe CH, et al. Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. N Engl J Med. 2006; 354: 1477-1488.
96. Cho L, Topol EJ, Balog C, et al. Clinical benefit of glycoprotein IIb/IIIa blockade with abciximab is independent of gender: pooled analysis from EPIC, EPILOG and EPISTENT trials (Evaluation of 7E3 for the Prevention of Ischemic Complications, Evaluation in Percutaneous Transluminal Coronary Angioplasty to Improve Long-Term Outcome With Abciximab GP IIb/IIIa Blockade, Evaluation of Platelet IIb/IIIa Inhibitor for Stent). J Am Coll Cardiol. 2000; 36: 381-386.
97. Boersma E, Harrington RA, Moliterno DJ, et al. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials. Lancet. 2002; 359: 189-198. (Pubitemid 34113814)
98. Boden WE, O'Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007; 356: 1503-1516. (Pubitemid 46588415)
99. Kemp HG, Kronmal RA, Vlietstra RE, et al. Seven-year survival of patients with normal or near normal coronary arteriograms: a CASS registry study. J Am Coll Cardiol. 1986; 7: 479-483. (Pubitemid 16164373)
100. Kaski JC, Rosano GM, Collins P, et al. Cardiac syndrome X: clinical characteristics and left ventricular function. Long-term follow-up study. J Am Coll Cardiol. 1995; 25: 807-814.
101. Diver DJ, Bier JD, Ferreira PE, et al. Clinical and arteriographic characterization of patients with unstable angina without critical coronary arterial narrowing (from the TIMI-IIIA Trial). Am J Cardiol. 1994; 74: 531-537. (Pubitemid 24279931)
102. Bugiardini R, Manfrini O, Pizzi C, et al. Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation. 2004; 109: 2518-2523. (Pubitemid 38720550)
103. Lanza GA, Colonna G, Pasceri V, et al. Atenolol versus amlodipine versus isosorbide-5-mononitrate on anginal symptoms in syndrome X. Am J Cardiol. 1999; 84: 854-856, A8. (Pubitemid 29469799)
104. Sutsch G, Oechslin E, Mayer I, et al. Effect of diltiazem on coronary flow reserve in patients with microvascular angina. Int J Cardiol. 1995; 52: 135-143.
105. Pizzi C, Manfrini O, Fontana F, et al. Angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cardiac Syndrome X: role of superoxide dismutase activity. Circulation. 2004; 109: 53-58. (Pubitemid 38056021)
106. Kayikcioglu M, Payzin S, Yavuzgil O, et al. Benefits of statin treatment in cardiac syndrome-X1. Eur Heart J. 2003; 24: 1999-2005. (Pubitemid 37420446)
107. Chen JW, Hsu NW, Wu TC, et al. Long-term angiotensin-converting enzyme inhibition reduces plasma asymmetric dimethylarginine and improves endothelial nitric oxide bioavailability and coronary microvascular function in patients with syndrome X. Am J Cardiol. 2002; 90: 974-982.
108. Eriksson BE, Tyni-Lenné R, Svedenhag J, et al. Physical training in Syndrome X: physical training counteracts deconditioning and pain in Syndrome X. J Am Coll Cardiol. 2000; 36: 1619-1625.
109. Cannon RO III, Quyyumi AA, Mincemoyer R, et al. Imipramine in patients with chest pain despite normal coronary angiograms. N Engl J Med. 1994; 330: 1411-1417. (Pubitemid 24139233)
110. Lerman A, Burnett JC Jr, Higano ST, et al. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation. 1998; 97: 2123-2128. (Pubitemid 28262119)
111. Palloshi A, Fragasso G, Piatti P, et al. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries. Am J Cardiol. 2004; 93: 933-935. (Pubitemid 38429612)
112. Dzavik V, Cotter G, Reynolds HR, et al. Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study. Eur Heart J. 2007; 28: 1109-1116. (Pubitemid 47343883)
113. Mehta PK, Goykhman P, Thomson LE, et al. Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease. JACC Cardiovasc Imaging. 2011; 4: 514-522.