Abnormal Coronary Vasomotion as a Prognostic Indicator of Cardiovascular Events in Women: Results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)

Circulation

Volumn 109, Issue 6, 2004, Pages 722-725

  Von Mering, Gregory O ^a   Arant, Christopher B ^a   Wessel, Timothy R ^a   McGorray, Susan P ^a   Bairey Merz, C Noel ^b   Sharaf, Barry L ^c   Smith, Karen M ^a   Olson, Marian B ^d   Johnson, B Delia ^d   Sopko, George ^e   Handberg, Eileen ^a   Pepine, Carl J ^a   Kerensky, Richard A ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Acetylcholine; Coronary disease; Endothelium; Prognosis; Women

Indexed keywords

ACETYLCHOLINE; ADENOSINE; GLYCERYL TRINITRATE;

ADULT; AGE; AGED; ANGIOCARDIOGRAPHY; ARTICLE; ATHEROSCLEROSIS; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; CORONARY BLOOD VESSEL; DEATH; DIABETES MELLITUS; DISEASE SEVERITY; DOPPLER FLOWMETRY; DYSLIPIDEMIA; EPICARDIUM; FEMALE; FOLLOW UP; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; SMOKING; STROKE; TOBACCO; VASCULAR ENDOTHELIUM; VASOMOTOR REFLEX;

ACETYLCHOLINE; ADENOSINE; CARDIOVASCULAR DISEASES; CORONARY ANGIOGRAPHY; CORONARY ARTERIOSCLEROSIS; CORONARY CIRCULATION; CORONARY VESSELS; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; LASER-DOPPLER FLOWMETRY; MIDDLE AGED; MYOCARDIAL ISCHEMIA; NITROGLYCERIN; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SYNDROME; VASODILATION; VASODILATOR AGENTS;

EID: 10744223065     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000115525.92645.16     Document Type: Article

References (15)

1. Suwaidi JA, Hamasaki S, Higano ST, et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation. 2000;101:948-954.
2. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899-1906.
3. Heitzer T, Schlinzig T, Krohn K, et al. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 2001;104:2673-2678.
4. Widlansky ME, Gokce N, Keaney JF. The clinical implications of endothelial dysfunction. J Am Coll Cardiol. 2003;42:1149-1160.
5. Quyyumi AA. Prognostic value of endothelial function. Am J Cardiol. 2003;91(suppl):19H-24H.
6. Halcox JPJ, Schenke WH, Zalos G, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002;106:653-658.
7. Merz CN, Kelsey SF, Pepine CJ, et al. The Women's Ischemia Syndrome Evaluation (WISE) study: protocol design, methodology, and feasibility report. J Am Coll Cardiol. 1999;33:1453-1461.
8. Reis SE, Holubkov R, Lee JS, et al. Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease: results from the pilot phase of the Women's Ischemia Syndrome Evaluation (WISE) study. J Am Coll Cardiol. 1999;33:1469-1475.
9. Zeiher AM, Drexler H, Wollschläger H, et al. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation. 1991;83:391-401.
10. Hasdai D, Gibbons RJ, Holmes DR Jr, et al. Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation. 1997;96:3390-3395.
11. Harrison DG, Bates JN. The nitrovasodilators: new ideas about old drugs. Circulation. 1993;87:1461-1467.
12. Doucette JW, Corl PD, Payne HM, et al. Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity. Circulation. 1992;85:1899-1911.
13. Sharaf B, Pepine CJ, Reis S, et al. Detailed angiographic analysis of women presenting with suspected ischemic chest pain: pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study angiographic core laboratory. Am J Cardiol. 2001;87:937-941.
14. Al Suwaidi J, Hamasaki S, Higano ST, et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation. 2000;101:948-954.
15. Reis SE, Holubkov R, Conrad Smith AJ, et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J. 2001;141:735-741.