Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes

Traffic

Volumn 16, Issue 1, 2015, Pages 85-98

  Fodor, Krisztián ^a,c   Wolf, Janina ^b   Reglinski, Katharina ^b   Passon, Daniel M ^a   Lou, Ye ^a   Schliebs, Wolfgang ^b   Erdmann, Ralf ^b   Wilmanns, Matthias ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Binding site compaction; Conformational dynamics; Membrane translocation; Peroxisomal import receptor; Protein import efficiency

Indexed keywords

ALANINE GLYOXYLATE AMINOTRANSFERASE; LYSINE; MATRIX PROTEIN; PEX5 PROTEIN; PTS1 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CELL RECEPTOR; LIGAND; MEMBRANE PROTEIN; PEROXISOME-TARGETING SIGNAL 1 RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; ISOTHERMAL TITRATION CALORIMETRY; PEROXISOME; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; WILD TYPE; HUMAN; INTRACELLULAR MEMBRANE; METABOLISM;

CARRIER PROTEINS; HUMANS; INTRACELLULAR MEMBRANES; LIGANDS; MEMBRANE PROTEINS; PEROXISOMES; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84919862245     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/tra.12238     Document Type: Article

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