Conformational plasticity of the lipid transfer protein SCP2

Biochemistry

Volumn 46, Issue 27, 2007, Pages 7980-7991

  Filipp, Fabian V ^a,d   Sattler, Michael ^a,b,c  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE HYDROGEN EXCHANGE; CONFORMATIONAL PLASTICITY; LIPID BINDING POCKET;

CHEMICAL SHIFT; CONFORMATIONS; FATTY ACIDS; LIPIDS; PARAMAGNETISM; PLASTICITY; RELAXATION PROCESSES;

PROTEINS;

ACYL COENZYME A; AMIDE; CARRIER PROTEIN; CHOLESTEROL; HYDROGEN; PEPTIDE; STEROL CARRIER PROTEIN 2;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ORGANELLE; CONFORMATIONAL TRANSITION; FATTY ACID METABOLISM; HUMAN; HYDROPHOBICITY; ION EXCHANGE; LIGAND BINDING; LIPID TRANSPORT; MAGNETISM; MEASUREMENT; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; PEROXISOME; PLASTICITY; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

CARRIER PROTEINS; ELECTRON SPIN RESONANCE SPECTROSCOPY; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SPIN LABELS;

EID: 34447297842     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi6025616     Document Type: Article

References (40)

1. Dansen, T. B., Westerman, J., Wouters, F. S., Wanders, R. J., van Hoek, A., Gadella, T. W., Jr., and Wirtz, K. W. (1999) High-affinity binding of very-long-chain fatty acyl-CoA esters to the peroxisomal non-specific lipid-transfer protein (sterol carrier protein-2), Biochem. J. 339 (Part 1), 193-199.
2. Frolov, A., Cho, T. H., Billheimer, J. T., and Schroeder, F. (1996) Sterol carrier protein-2, a new fatty acyl coenzyme A-binding protein, J. Biol. Chem. 271, 31878-31884.
3. Gallegos, A. M., Atshaves, B. P., Storey, S. M., Starodub, O., Petrescu, A. D., Huang, H., McIntosh, A. L., Martin, G. G., Chao, H., Kier, A. B., and Schroeder, F. (2001) Gene structure, intracellular localization, and functional roles of sterol carrier protein-2, Prog. Lipid Res. 40, 498-563.
4. Fuchs, M., Hafer, A., Munch, C., Kannenberg, F., Teichmann, S., Scheibner, J., Stange, E. F., and Seedorf, U. (2001) Disruption of the sterol carrier protein 2 gene in mice impairs biliary lipid and hepatic cholesterol metabolism, J. Biol. Chem. 276, 48058-48065.
5. Noland, B. J., Arebalo, R. E., Hansbury, E., and Scallen, T. J. (1980) Purification and properties of sterol carrier protein2, J. Biol. Chem. 255, 4282-4289.
6. Seedorf, U., Raabe, M., Ellinghaus, P., Kannenberg, F., Fobker, M., Engel, T., Denis, S., Wouters, F., Wirtz, K. W., Wanders, R. J., Maeda, N., and Assmann, G. (1998) Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function, Genes Dev. 12, 1189-1201.
7. Russell, D. W. (2003) The enzymes, regulation, and genetics of bile acid synthesis, Annu. Rev. Biochem. 72, 137-174.
8. Wanders, R. J., Vreken, P., Ferdinandusse, S., Jansen, G. A., Waterham, H. R., van Roermund, C. W., and Van Grunsven, E. G. (2001) Peroxisomal fatty acid alpha- and beta-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases, Biochem. Soc. Trans. 29, 250-267.
9. Seedorf, U., Ellinghaus, P., and Roch, Nofer, J. (2000) Sterol carrier protein-2, Biochim. Biophys. Acta 1486, 45-54.
10. Haapalainen, A. M., van Aalten, D. M., Merilainen, G., Jalonen, J. E., Pirila, P., Wierenga, R. K., Hiltunen, J. K., and Glumoff, T. (2001) Crystal structure of the liganded SCP-2-like domain of human peroxisomal multifunctional enzyme type 2 at 1.75 Å resolution, J. Mol. Biol. 313, 1127-1138.
11. Dyer, D. H., Lovell, S., Thoden, J. B., Holden, H. M., Rayment, I., and Lan, Q. (2003) The structural determination of an insect sterol carrier protein-2 with a ligand-bound C16 fatty acid at 1.35-Å resolution, J. Biol. Chem. 278, 39085-39091.
12. Garcia, F. L., Szyperski, T., Dyer, J. H., Choinowski, T., Seedorf, U., Hauser, H., and Wuthrich, K. (2000) NMR structure of the sterol carrier protein-2: implications for the biological role, J. Mol. Biol. 295, 595-603.
13. Choinowski, T., Hauser, H., and Piontek, K. (2000) Structure of sterol carrier protein 2 at 1.8 Å resolution reveals a hydrophobic tunnel suitable for lipid binding, Biochemistry 39, 1897-1902.
14. Weber, F. E., Dyer, J. H., Garcia, F. L., Werder, M., Szyperski, T., and Wuthrich, K. (1998) In pre-sterol carrier protein 2 (SCP2) in solution the leader peptide is flexibly disordered, and residues 21-143 adopt the same globular fold as in mature SCP2), Cell. Mol. Life Sci. 54, 751-759.
15. Gatto, G. J., Jr., Geisbrecht, B. V., Gould, S. J., and Berg, J. M. (2000) Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5, Nat. Struct. Biol. 7, 1091-1095.
16. Heiland, I., and Erdmann, R. (2005) Biogenesis of peroxisomes. Topogenesis of the peroxisomal membrane and matrix proteins, FEBS J. 272, 2362-2372.
17. Lensink, M. F., Haapalainen, A. M., Hiltunen, J. K., Glumoff, T., and Juffer, A. H. (2002) Response of SCP-2L domain of human MFE-2 to ligand removal: binding site closure and burial of peroxisomal targeting signal, J. Mol. Biol. 323, 99-113.
18. Schroeder, F., Frolov, A., Starodub, O., Atshaves, B. B., Russell, W., Petrescu, A., Huang, H., Gallegos, A. M., McIntosh, A., Tahotna, D., Russell, D. H., Billheimer, J. T., Baum, C. L., and Kier, A. B. (2000) Pro-sterol carrier protein-2: role of the N-terminal presequence in structure, function, and peroxisomal targeting, J. Biol. Chem. 275, 25547-25555.
19. Stolowich, N. J., Petrescu, A. D., Huang, H., Martin, G. G., Scott, A. I., and Schroeder, F. (2002) Sterol carrier protein-2: structure reveals function, Cell. Mol. Life Sci. 59, 193-212.
20. Stanley, W. A., Sokolova, A., Brown, A., Clarke, D. T., Wilmanns, M., and Svergun, D. I. (2004) Synergistic use of synchrotron radiation techniques for biological samples in solution: a case study on protein-ligand recognition by the peroxisomal import receptor Pex5p, J. Synchrotron Radiat. 11, 490-496.
21. Sattler, M., Schleucher, J. and Griesinger, C. (1999) Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients, Prog. NMR Spectrosc. 34, 93-158.
22. Reis, S., Moutinho, C. G., Matos, C., de Castro, B., Gameiro, P., and Lima, J. L. (2004) Noninvasive methods to determine the critical micelle concentration of some bile acid salts, Anal. Biochem. 334, 117-126.
23. Powell, G. L, Grothusen, J. R., Zimmerman, J. K., Evans, C. A., and Fish, W. W. (1981) A re-examination of some properties of fatty acyl-CoA micelles, J. Biol. Chem. 256, 12740-12747.
24. 15N NMR relaxation, Biochemistry 33, 5984-6003.
25. Mulder, F. A., Spronk, C. A., Slijper, M., Kaptein, R., and Boelens, R. (1996) Improved HSQC experiments for the observation of exchange broadened signals, J. Biomol. NMR 8, 223-228.
26. Stanley, W. A., Filipp, F. V., Kursula, P., Erdmann, R., Schliebs, W., Sattler, M., and Wilmanns, M. (2006) Recognition of a functional peroxisome type 1 target by the dynamic import receptor Pex5p, Mol. Cell 24, 653-663.
27. Battiste, J. L., and Wagner, G. (2000) Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data, Biochemistry 39, 5355-5365.
28. Stolowich, N., Frolov, A., Petrescu, A. D., Scott, A. I., Billheimer, J. T., and Schroeder, F. (1999) Holo-sterol carrier protein-2. (13)C NMR investigation of cholesterol and fatty acid binding sites, J. Biol. Chem. 274, 35425-35433.
29. Huyghues-Despointes, B. M., Pace, C. N., Englander, S. W., and Scholtz, J. M. (2001) Measuring the conformational stability of a protein by hydrogen exchange, Methods Mol. Biol. 168, 69-92.
30. Baxter, N. J., Hosszu, L. L., Waltho, J. P., and Williamson, M. P. (1998) Characterisation of low free-energy excited states of folded proteins, J. Mol. Biol. 284, 1625-1639.
31. Mulder, F. A., van Tilborg, P. J., Kaptein, R., and Boelens, R. (1999) Microsecond time scale dynamics in the RXR DNA-binding domain from a combination of spin-echo and off-resonance rotating frame relaxation measurements, J. Biomol. NMR 13, 275-288.
32. Palmer, A. G., III, Grey, M. J., and Wang, C. (2005) Solution NMR spin relaxation methods for characterizing chemical exchange in high-molecular-weight systems, Methods Enzymol. 394, 430-465.
33. Mueller, L., Legault, P., and Pardi, A. (1995) Improved RNA structure determination by detection of NOE contacts to exchange-broadened amino protons, J. Am. Chem. Soc. 117, 11043-11048.
34. McNew, J. A., and Goodman, J. M. (1996) The targeting and assembly of peroxisomal proteins: some old rules do not apply, Trends Biochem. Sci. 21, 54-58.
35. Schroeder, F., Myers-Payne, S. C., Billheimer, J. T., and Wood, W. G. (1995) Probing the ligand binding sites of fatty acid and sterol carrier proteins: effects of ethanol, Biochemistry 34, 11919-11927.
36. Mulder, F. A., Skrynnikov, N. R., Hon, B., Dahlquist, F. W., and Kay, L. E. (2001) Measurement of slow (μs-ras) time scale dynamics in protein side chains by (15)N relaxation dispersion NMR spectroscopy: application to Asn and Gln residues in a cavity mutant of T4 lysozyme, J. Am. Chem. Soc. 123, 967-975.
37. Nichesola, D., Perduca, M., Capaldi, S., Carrizo, M. E., Righetti, P. G., and Monaco, H. L. (2004) Crystal structure of chicken liver basic fatty acid-binding protein complexed with cholic acid, Biochemistry 43, 14072-14079.
38. Constantine, K. L., Friedrichs, M. S., Wittekind, M., Jamil, H., Chu, C. H., Parker, R. A., Goldfarb, V., Mueller, L., and Farmer, B. T., II (1998) Backbone and side chain dynamics of uncomplexed human adipocyte and muscle fatty acid-binding proteins, Biochemistry 37, 7965-7980.
39. Zhu, L., Kurian, E., Prendergast, F. G., and Kemple, M. D. (1999) Dynamics of palmitic acid complexed with rat intestinal fatty acid binding protein, Biochemistry 38, 1554-1561.
40. 13C NMR study, Proc. Natl. Acad. Sci. U.S.A. 81, 3718-3722.