Stromal expression of carbonic anhydrase IX in esophageal cancer

Clinical and Translational Oncology

Volumn 16, Issue 11, 2014, Pages 966-972

  Jomrich, G ^a   Jesch, B ^a   Birner, P ^a   Schwameis, K ^a   Paireder, M ^a   Asari, R ^a   Schoppmann, S F ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cancer associated stroma; Carbonic anhydrase IX; Carcinoma associated fibroblasts (CAFs); Esophageal cancer; Tumor micro environment (TME)

Indexed keywords

CARBONATE DEHYDRATASE IX; FORMALDEHYDE; PARAFFIN; PROTEIN TYROSINE KINASE; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; TUMOR ANTIGEN; TUMOR MARKER;

ADJUVANT THERAPY; ADULT; ANTIGEN EXPRESSION; ARTICLE; CANCER STAGING; CANCER SURGERY; DISEASE FREE SURVIVAL; ENZYME INHIBITION; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS CANCER; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; SQUAMOUS CELL CARCINOMA; STROMA; TUMOR INVASION; AGED; BIOSYNTHESIS; CARCINOMA; ENZYMOLOGY; ESOPHAGUS TUMOR; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; PATHOLOGY; PHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; TUMOR MICROENVIRONMENT;

ADULT; AGED; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASES; CARCINOMA; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT;

EID: 84919847287     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-014-1180-z     Document Type: Article

References (31)

1. De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol. 2003;200(4):429–47. doi:10.1002/path.1398.
2. Bremnes RM, Donnem T, Al-Saad S, Al-Shibli K, Andersen S, Sirera R, et al. The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer. J Thorac Oncol: Off Publ Int Assoc Study Lung Cancer. 2011;6(1):209–17. doi:10.1097/JTO.0b013e3181f8a1bd.
3. Mueller MM, Fusenig NE. Friends or foes—bipolar effects of the tumour stroma in cancer. Nat Rev Cancer. 2004;4(11):839–49. doi:10.1038/nrc1477.
4. Hofmeister V, Schrama D, Becker JC. Anti-cancer therapies targeting the tumor stroma. Cancer Immunol Immunother: CII. 2008;57(1):1–17. doi:10.1007/s00262-007-0365-5.
5. Pastorek J, Pastorekova S, Callebaut I, Mornon JP, Zelnik V, Opavsky R, et al. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. Oncogene. 1994;9(10):2877–88.
6. Loncaster JA, Harris AL, Davidson SE, Logue JP, Hunter RD, Wycoff CC, et al. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 2001;61(17):6394–9.
7. Koukourakis MI, Giatromanolaki A, Sivridis E, Simopoulos K, Pastorek J, Wykoff CC, et al. Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy. Clin Cancer Res: Off J Am Assoc Cancer Res. 2001;7(11):3399–403.
8. Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff CC, Gatter KC, et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 2001;61(21):7992–8.
9. Swinson DE, Jones JL, Richardson D, Wykoff C, Turley H, Pastorek J, et al. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J Clin Oncol: Off J Am Soc Clin Oncol. 2003;21(3):473–82.
10. Hui EP, Chan AT, Pezzella F, Turley H, To KF, Poon TC, et al. Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Clin Cancer Res: Off J Am Assoc Cancer Res. 2002;8(8):2595–604.
11. Chia SK, Wykoff CC, Watson PH, Han C, Leek RD, Pastorek J, et al. Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. J Clin Oncol: Off J Am Soc Clin Oncol. 2001;19(16):3660–8.
12. Andersen S, Eilertsen M, Donnem T, Al-Shibli K, Al-Saad S, Busund LT, et al. Diverging prognostic impacts of hypoxic markers according to NSCLC histology. Lung Cancer. 2011;72(3):294–302. doi:10.1016/j.lungcan.2010.10.006.
13. Kon-no H, Ishii G, Nagai K, Yoshida J, Nishimura M, Nara M, et al. Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma. Lung Cancer. 2006;54(3):409–18. doi:10.1016/j.lungcan.2006.08.017.
14. Cleven AH, van Engeland M, Wouters BG, de Bruine AP. Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell Oncol: Off J Int Soc Cell Oncol. 2007;29(3):229–40.
15. Colpaert CG, Vermeulen PB, Fox SB, Harris AL, Dirix LY, Van Marck EA. The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis. Breast Cancer Res Treat. 2003;81(2):137–47. doi:10.1023/A:1025702330207.
16. Crew KD, Neugut AI. Epidemiology of upper gastrointestinal malignancies. Semin Oncol. 2004;31(4):450–64.
17. Pera M, Manterola C, Vidal O, Grande L. Epidemiology of esophageal adenocarcinoma. J Surg Oncol. 2005;92(3):151–9. doi:10.1002/jso.20357.
18. Ku GY, Ilson DH. Esophagogastric cancer: targeted agents. Cancer Treat Rev. 2010;36(3):235–48. doi:10.1016/j.ctrv.2009.12.009.
19. Birner P, Jesch B, Friedrich J, Riegler M, Zacherl J, Hejna M, et al. Carbonic anhydrase IX overexpression is associated with diminished prognosis in esophageal cancer and correlates with Her-2 expression. Ann Surg Oncol. 2011;18(12):3330–7. doi:10.1245/s10434-011-1730-3.
20. Schoppmann SF, Jesch B, Friedrich J, Wrba F, Schultheis A, Pluschnig U, et al. Expression of Her-2 in carcinomas of the esophagus. Am J Surg Pathol. 2010;34(12):1868–73. doi:10.1097/PAS.0b013e3181f8be17.
21. Schoppmann SF, Jesch B, Zacherl J, Riegler MF, Friedrich J, Birner P. Lymphangiogenesis and lymphovascular invasion diminishes prognosis in esophageal cancer. Surgery. 2013;153(4):526–34. doi:10.1016/j.surg.2012.10.007.
22. Schoppmann SF, Jesch B, Friedrich J, Jomrich G, Maroske F, Birner P. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer. Clin Exp Metastasis. 2012;29(6):615–24. doi:10.1007/s10585-012-9475-3.
23. Breiteneder-Geleff S, Soleiman A, Horvat R, Amann G, Kowalski H, Kerjaschki D. Podoplanin—a specific marker for lymphatic endothelium expressed in angiosarcoma. Verh Dtsch Ges Pathol. 1999;83:270–5.
24. Schoppmann SF, Birner P, Studer P, Breiteneder-Geleff S. Lymphatic microvessel density and lymphovascular invasion assessed by anti-podoplanin immunostaining in human breast cancer. Anticancer Res. 2001;21(4A):2351–5.
25. Pham NA, Morrison A, Schwock J, Aviel-Ronen S, Iakovlev V, Tsao MS, et al. Quantitative image analysis of immunohistochemical stains using a CMYK color model. Diagn Pathol. 2007;2:8. doi:10.1186/1746-1596-2-8.
26. Brockton NT, Klimowicz AC, Bose P, Petrillo SK, Konno M, Rudmik L, et al. High stromal carbonic anhydrase IX expression is associated with nodal metastasis and decreased survival in patients with surgically-treated oral cavity squamous cell carcinoma. Oral Oncol. 2012;48(7):615–22. doi:10.1016/j.oraloncology.2012.01.018.
27. Nakao M, Ishii G, Nagai K, Kawase A, Kenmotsu H, Kon-No H, et al. Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma. Cancer. 2009;115(12):2732–43. doi:10.1002/cncr.24303.
28. Schoppmann SF, Jesch B, Riegler MF, Maroske F, Schwameis K, Jomrich G, et al. Podoplanin expressing cancer associated fibroblasts are associated with unfavourable prognosis in adenocarcinoma of the esophagus. Clin Exp Metastasis. 2012;. doi:10.1007/s10585-012-9549-2.
29. Gieling RG, Williams KJ. Carbonic anhydrase IX as a target for metastatic disease. Bioorg Med Chem. 2012. doi:10.1016/j.bmc.2012.09.062.
30. Shin HJ, Rho SB, Jung DC, Han IO, Oh ES, Kim JY. Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion. J Cell Sci. 2011;124(Pt 7):1077–87. doi:10.1242/jcs.072207.
31. Ito S, Ishii G, Hoshino A, Hashimoto H, Neri S, Kuwata T, et al. Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity. Biochem Biophys Res Commun. 2012;422(1):194–9. doi:10.1016/j.bbrc.2012.04.158.