메뉴 건너뛰기




Volumn 72, Issue 3, 2011, Pages 294-302

Diverging prognostic impacts of hypoxic markers according to NSCLC histology

Author keywords

CAIX; GLUT1; HIF1 ; HIF2 ; LDH5; NSCLC; Prognostic impact; Stroma

Indexed keywords

CARBONATE DEHYDRATASE IX; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; LACTATE DEHYDROGENASE;

EID: 79955475949     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2010.10.006     Document Type: Article
Times cited : (42)

References (56)
  • 1
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J., Dayan F., Mazure N.M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006, 441:437-443.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 2
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza G.L., Wang G.L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992, 12:5447-5454.
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 3
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema M., Taya S., Yokotani N., Sogawa K., Matsuda Y., Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997, 94:4273-4278.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 4
    • 0031733828 scopus 로고    scopus 로고
    • Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit. HIF3alpha
    • Gu Y.Z., Moran S.M., Hogenesch J.B., Wartman L., Bradfield C.A. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit. HIF3alpha. Gene Exp 1998, 7:205-213.
    • (1998) Gene Exp , vol.7 , pp. 205-213
    • Gu, Y.Z.1    Moran, S.M.2    Hogenesch, J.B.3    Wartman, L.4    Bradfield, C.A.5
  • 5
    • 64249144149 scopus 로고    scopus 로고
    • Gene regulation in the adaptive process to hypoxia in lung epithelial cells
    • Clerici C., Planes C. Gene regulation in the adaptive process to hypoxia in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009, 296:L267-L274.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296
    • Clerici, C.1    Planes, C.2
  • 6
    • 34247236896 scopus 로고    scopus 로고
    • Hypoxia rapidly activates HIF-3α mRNA expression
    • 02-0963fje
    • Heidbreder M., Frohlich F., Johren O., et al. Hypoxia rapidly activates HIF-3α mRNA expression. FASEB J 2003, 02-0963fje.
    • (2003) FASEB J
    • Heidbreder, M.1    Frohlich, F.2    Johren, O.3
  • 7
    • 33745259854 scopus 로고    scopus 로고
    • Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha
    • Li Q.F., Wang X.R., Yang Y.W., LIN H. Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha. Cell Res 2006, 16:548-558.
    • (2006) Cell Res , vol.16 , pp. 548-558
    • Li, Q.F.1    Wang, X.R.2    Yang, Y.W.3    Lin, H.4
  • 8
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H., McKnight S.L., Russell D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997, 11:72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 9
    • 33751071832 scopus 로고    scopus 로고
    • Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines
    • Liu Y.L., Yu J.M., Song X.R., Wang X.W., Xing L.G., Gao B.B. Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines. Cancer Biol Ther 2006, 5:1320-1326.
    • (2006) Cancer Biol Ther , vol.5 , pp. 1320-1326
    • Liu, Y.L.1    Yu, J.M.2    Song, X.R.3    Wang, X.W.4    Xing, L.G.5    Gao, B.B.6
  • 10
    • 33947307906 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1[alpha] regulates lung adenocarcinoma cell invasion
    • Shyu K.G., Hsu F.L., Wang M.J., Wang B.W., Lin S. Hypoxia-inducible factor 1[alpha] regulates lung adenocarcinoma cell invasion. Exp Cell Res 2007, 313:1181-1191.
    • (2007) Exp Cell Res , vol.313 , pp. 1181-1191
    • Shyu, K.G.1    Hsu, F.L.2    Wang, M.J.3    Wang, B.W.4    Lin, S.5
  • 11
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 12
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche J., Ilc K., Laferriere J., Trottier E., Dayan F., Mazure N.M., et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 2009, 69:358-368.
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6
  • 14
    • 60549083256 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    • Semenza G.L. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol 2009, 19:12-16.
    • (2009) Semin Cancer Biol , vol.19 , pp. 12-16
    • Semenza, G.L.1
  • 15
    • 3142631966 scopus 로고    scopus 로고
    • The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure
    • Milosevic M., Fyles A., Hedley D., Hill R., et al. The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure. Semin Radiat Oncol 2004, 14:249-258.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 249-258
    • Milosevic, M.1    Fyles, A.2    Hedley, D.3    Hill, R.4
  • 16
    • 0042031680 scopus 로고    scopus 로고
    • Tumor microenvironment and the response to anticancer therapy
    • Brown J.M. Tumor microenvironment and the response to anticancer therapy. Cancer Biol Ther 2002, 1:453-458.
    • (2002) Cancer Biol Ther , vol.1 , pp. 453-458
    • Brown, J.M.1
  • 17
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Gray L.H., Conger A.D., Ebert M., Hornsey S., Scott O.C. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953, 26:638-648.
    • (1953) Br J Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3    Hornsey, S.4    Scott, O.C.5
  • 18
    • 54049134838 scopus 로고    scopus 로고
    • Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis
    • Vaupel P. Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. Oncologist 2008, 13(Suppl. 3):21-26.
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 3 , pp. 21-26
    • Vaupel, P.1
  • 19
    • 33645079888 scopus 로고    scopus 로고
    • An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    • Le Q.T., Chen E., Salim A., Cao H., Kong C.S., Whyte R., et al. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res 2006, 12:1507-1514.
    • (2006) Clin Cancer Res , vol.12 , pp. 1507-1514
    • Le, Q.T.1    Chen, E.2    Salim, A.3    Cao, H.4    Kong, C.S.5    Whyte, R.6
  • 22
    • 70350120598 scopus 로고    scopus 로고
    • Histologic considerations for individualized systemic therapy approaches for the management of non-small cell lung cancer
    • West H., Harpole D., Travis W. Histologic considerations for individualized systemic therapy approaches for the management of non-small cell lung cancer. Chest 2009, 136:1112-1118.
    • (2009) Chest , vol.136 , pp. 1112-1118
    • West, H.1    Harpole, D.2    Travis, W.3
  • 23
    • 36749024002 scopus 로고    scopus 로고
    • Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer
    • Donnem T., Al-Saad S., Al-Shibli K., Delghandi M.P., Persson M., Nilsen M.N., et al. Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer. Clin Cancer Res 2007, 13:6649-6657.
    • (2007) Clin Cancer Res , vol.13 , pp. 6649-6657
    • Donnem, T.1    Al-Saad, S.2    Al-Shibli, K.3    Delghandi, M.P.4    Persson, M.5    Nilsen, M.N.6
  • 24
    • 58149106094 scopus 로고    scopus 로고
    • Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells
    • Donnem T., Al-Saad S., Al-Shibli K., Andersen S., Busund L.T., Bremnes R.M. Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells. J Thorac Oncol 2008, 3:963-970.
    • (2008) J Thorac Oncol , vol.3 , pp. 963-970
    • Donnem, T.1    Al-Saad, S.2    Al-Shibli, K.3    Andersen, S.4    Busund, L.T.5    Bremnes, R.M.6
  • 25
    • 0034941320 scopus 로고    scopus 로고
    • Histological typing of lung and pleural tumours: third edition
    • Gibbs A.R., Thunnissen F.B. Histological typing of lung and pleural tumours: third edition. J Clin Pathol 2001, 54:498-499.
    • (2001) J Clin Pathol , vol.54 , pp. 498-499
    • Gibbs, A.R.1    Thunnissen, F.B.2
  • 26
    • 52649163840 scopus 로고    scopus 로고
    • Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer
    • Al-Shibli K.I., Donnem T., Al-Saad S., Persson M., Bremnes R.M., Busund L.T. Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer. Clin Cancer Res 2008, 14:5220-5227.
    • (2008) Clin Cancer Res , vol.14 , pp. 5220-5227
    • Al-Shibli, K.I.1    Donnem, T.2    Al-Saad, S.3    Persson, M.4    Bremnes, R.M.5    Busund, L.T.6
  • 27
    • 0035860147 scopus 로고    scopus 로고
    • Relation of hypoxia inducible factor 1[agr] and 2[agr] in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
    • Giatromanolaki A., Koukourakis M.I., Sivridis E., Turley H., Talks K., Pezzella F., et al. Relation of hypoxia inducible factor 1[agr] and 2[agr] in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001, 85:881-890.
    • (2001) Br J Cancer , vol.85 , pp. 881-890
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Turley, H.4    Talks, K.5    Pezzella, F.6
  • 28
    • 0037531790 scopus 로고    scopus 로고
    • DEC1 (STRA13) protein expression relates to hypoxia-inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer
    • Giatromanolaki A., Koukourakis M.I., Sivridis E., Turley H., Wykoff C.C., Gatter K.C., et al. DEC1 (STRA13) protein expression relates to hypoxia-inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. J Pathol 2003, 200:222-228.
    • (2003) J Pathol , vol.200 , pp. 222-228
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Turley, H.4    Wykoff, C.C.5    Gatter, K.C.6
  • 29
    • 23744479831 scopus 로고    scopus 로고
    • Expression of HIF-1[alpha], CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
    • Kim S.J., Rabbani Z.N., Dewhirst M.W., Vujaskovic Z., Vollmer R.T., Schreiber E.G., et al. Expression of HIF-1[alpha], CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer 2005, 49:325-335.
    • (2005) Lung Cancer , vol.49 , pp. 325-335
    • Kim, S.J.1    Rabbani, Z.N.2    Dewhirst, M.W.3    Vujaskovic, Z.4    Vollmer, R.T.5    Schreiber, E.G.6
  • 30
    • 0037315252 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
    • Swinson D.E., Jones J.L., Richardson D., Wykoff C., Turley H., Pastorek J., et al. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J Clin Oncol 2003, 21:473-482.
    • (2003) J Clin Oncol , vol.21 , pp. 473-482
    • Swinson, D.E.1    Jones, J.L.2    Richardson, D.3    Wykoff, C.4    Turley, H.5    Pastorek, J.6
  • 31
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A. Enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza G.L., Jiang B.H., Leung S.W., Passantino R., Concodet J.P., Maire P., et al. Hypoxia response elements in the aldolase A. Enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996, 271:32529-32537.
    • (1996) J Biol Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concodet, J.P.5    Maire, P.6
  • 32
    • 62749124795 scopus 로고    scopus 로고
    • Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show?
    • Kaluz S., Kaluzovβ M., Liao S.Y., Lerman M., Stanbridge E.J. Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show?. Biochim Biophys Acta (BBA) - Rev Cancer 2009, 1795:162-172.
    • (2009) Biochim Biophys Acta (BBA) - Rev Cancer , vol.1795 , pp. 162-172
    • Kaluz, S.1    Kaluzovß, M.2    Liao, S.Y.3    Lerman, M.4    Stanbridge, E.J.5
  • 33
    • 2442544693 scopus 로고    scopus 로고
    • Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1{alpha} and HIF-2{alpha} expression in lung epithelial cells: implication of natural antisense HIF-1{alpha}
    • Uchida T., Rossignol F., Matthay M.A., Mounier R., Couette S., Clottes E., et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1{alpha} and HIF-2{alpha} expression in lung epithelial cells: implication of natural antisense HIF-1{alpha}. J Biol Chem 2004, 279:14871-14878.
    • (2004) J Biol Chem , vol.279 , pp. 14871-14878
    • Uchida, T.1    Rossignol, F.2    Matthay, M.A.3    Mounier, R.4    Couette, S.5    Clottes, E.6
  • 34
    • 0033709613 scopus 로고    scopus 로고
    • Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities
    • Ishibashi H., Nakagawa K., Onimaru M., Castellanous E.J., Kaneda Y., Nakashima Y., et al. Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities. Cancer Res 2000, 60:6531-6536.
    • (2000) Cancer Res , vol.60 , pp. 6531-6536
    • Ishibashi, H.1    Nakagawa, K.2    Onimaru, M.3    Castellanous, E.J.4    Kaneda, Y.5    Nakashima, Y.6
  • 35
    • 33749472340 scopus 로고    scopus 로고
    • Nelfinavir down-regulates hypoxia-inducible factor 1{alpha} and VEGF expression and increases tumor oxygenation: implications for radiotherapy
    • Pore N., Gupta A.K., Cerniglia G.J., Jiang Z., Bernhard E.J., Evans S.M., et al. Nelfinavir down-regulates hypoxia-inducible factor 1{alpha} and VEGF expression and increases tumor oxygenation: implications for radiotherapy. Cancer Res 2006, 66:9252-9259.
    • (2006) Cancer Res , vol.66 , pp. 9252-9259
    • Pore, N.1    Gupta, A.K.2    Cerniglia, G.J.3    Jiang, Z.4    Bernhard, E.J.5    Evans, S.M.6
  • 36
    • 0346256583 scopus 로고    scopus 로고
    • Differential expression of hypoxia inducible factor-1 alpha and tumor cell proliferation between squamous cell carcinomas and adenocarcinomas among operable non-small cell lung carcinomas
    • Lee C.H., Lee M.K., Kang C.D., Kim Y.D., Park D.Y., Kim J.Y., et al. Differential expression of hypoxia inducible factor-1 alpha and tumor cell proliferation between squamous cell carcinomas and adenocarcinomas among operable non-small cell lung carcinomas. J Korean Med Sci 2003, 18:196-203.
    • (2003) J Korean Med Sci , vol.18 , pp. 196-203
    • Lee, C.H.1    Lee, M.K.2    Kang, C.D.3    Kim, Y.D.4    Park, D.Y.5    Kim, J.Y.6
  • 37
    • 0031978209 scopus 로고    scopus 로고
    • Expression of facilitative glucose transporter isoforms in lung carcinomas: its relation to histologic type, differentiation grade, and tumor stage
    • Ito T., Noguchi Y., Satoh S., Hayashi H., Inayama Y., Kitamura H. Expression of facilitative glucose transporter isoforms in lung carcinomas: its relation to histologic type, differentiation grade, and tumor stage. Mod Pathol 1998, 11:437-443.
    • (1998) Mod Pathol , vol.11 , pp. 437-443
    • Ito, T.1    Noguchi, Y.2    Satoh, S.3    Hayashi, H.4    Inayama, Y.5    Kitamura, H.6
  • 38
    • 42549102198 scopus 로고    scopus 로고
    • Lung cancer: a comparative study of metabolism related protein expression in cancer cells and tumor associated stroma
    • Koukourakis M.I., Giatromanolaki A., Bougioukas G., Sivridis E. Lung cancer: a comparative study of metabolism related protein expression in cancer cells and tumor associated stroma. Cancer Biol Ther 2007, 6:1476-1479.
    • (2007) Cancer Biol Ther , vol.6 , pp. 1476-1479
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Bougioukas, G.3    Sivridis, E.4
  • 39
    • 0030772117 scopus 로고    scopus 로고
    • Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival
    • Younes M., Brown R.W., Stephenson M., Gondo M., Cagle P.T. Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer 1997, 80:1046-1051.
    • (1997) Cancer , vol.80 , pp. 1046-1051
    • Younes, M.1    Brown, R.W.2    Stephenson, M.3    Gondo, M.4    Cagle, P.T.5
  • 40
    • 0036805178 scopus 로고    scopus 로고
    • Prognostic significance of p53, Ki-67, VEGF and Glut-1 in resected stage I adenocarcinoma of the lung
    • Minami K., Saito Y., Imamura H., Okamura A. Prognostic significance of p53, Ki-67, VEGF and Glut-1 in resected stage I adenocarcinoma of the lung. Lung Cancer 2002, 38:51-57.
    • (2002) Lung Cancer , vol.38 , pp. 51-57
    • Minami, K.1    Saito, Y.2    Imamura, H.3    Okamura, A.4
  • 41
    • 34147103548 scopus 로고    scopus 로고
    • FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: Correlations and prognostic values
    • Nguyen X.C., Lee W.W., Chung J.H., Park S.Y., Sung S.W., KIM Y.K. FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: Correlations and prognostic values. Eur J Radiol 2007, 62:214-219.
    • (2007) Eur J Radiol , vol.62 , pp. 214-219
    • Nguyen, X.C.1    Lee, W.W.2    Chung, J.H.3    Park, S.Y.4    Sung, S.W.5    Kim, Y.K.6
  • 42
    • 35148870732 scopus 로고    scopus 로고
    • Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines
    • Rastogi S., Banerjee S., Chellappan S., Simon G.R. Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines. Cancer Lett 2007, 257:244-251.
    • (2007) Cancer Lett , vol.257 , pp. 244-251
    • Rastogi, S.1    Banerjee, S.2    Chellappan, S.3    Simon, G.R.4
  • 43
    • 0141730410 scopus 로고    scopus 로고
    • Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
    • Koukourakis M.I., Giatromanolaki A., Sivridis E., Bougioukas G., Didilis V., Gatter K.C., et al. Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br J Cancer 2003, 89:877-885.
    • (2003) Br J Cancer , vol.89 , pp. 877-885
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Bougioukas, G.4    Didilis, V.5    Gatter, K.C.6
  • 44
    • 0035503362 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
    • Giatromanolaki A., Koukourakis M.I., Sivridis E., Pastorek J., Wykoff C.C., Gatter K.C., et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res 2001, 61:7992-7998.
    • (2001) Cancer Res , vol.61 , pp. 7992-7998
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Pastorek, J.4    Wykoff, C.C.5    Gatter, K.C.6
  • 46
    • 33750366916 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma
    • Kon-no H., Ishii G., Nagai K., Yoshida J., Nishimura M., Nara M., et al. Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma. Lung Cancer 2006, 54:409-418.
    • (2006) Lung Cancer , vol.54 , pp. 409-418
    • Kon-no, H.1    Ishii, G.2    Nagai, K.3    Yoshida, J.4    Nishimura, M.5    Nara, M.6
  • 47
    • 67649198500 scopus 로고    scopus 로고
    • Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma
    • Nakao M., Ishii G., Nagai K., Kawase A., Kenmutso H., Kon-no H., et al. Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma. Cancer 2009, 115:2732-2743.
    • (2009) Cancer , vol.115 , pp. 2732-2743
    • Nakao, M.1    Ishii, G.2    Nagai, K.3    Kawase, A.4    Kenmutso, H.5    Kon-no, H.6
  • 48
    • 33748079158 scopus 로고    scopus 로고
    • Tumor-associated carbonic anhydrases and their clinical significance
    • Pastorekova S., Parkkila S., Zavada J. Tumor-associated carbonic anhydrases and their clinical significance. Adv Clin Chem 2006, 42:167-216.
    • (2006) Adv Clin Chem , vol.42 , pp. 167-216
    • Pastorekova, S.1    Parkkila, S.2    Zavada, J.3
  • 49
    • 69949126786 scopus 로고    scopus 로고
    • Personalized medicine and inhibition of EGFR signaling in lung cancer
    • Gazdar A.F. Personalized medicine and inhibition of EGFR signaling in lung cancer. N Engl J Med 2009, 361:1018-1020.
    • (2009) N Engl J Med , vol.361 , pp. 1018-1020
    • Gazdar, A.F.1
  • 50
    • 67649414622 scopus 로고    scopus 로고
    • Individualizing therapy for non-small-cell lung cancer: a paradigm shift from empiric to integrated decision-making
    • Gandara D.R., Lara P.N., Mack P., Scagliotti G. Individualizing therapy for non-small-cell lung cancer: a paradigm shift from empiric to integrated decision-making. Clin Lung Cancer 2009, 10:148-150.
    • (2009) Clin Lung Cancer , vol.10 , pp. 148-150
    • Gandara, D.R.1    Lara, P.N.2    Mack, P.3    Scagliotti, G.4
  • 51
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A., Gray R., Perry M.C., Brahmer J., Schiller J.H., Dowlati A., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355:2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3    Brahmer, J.4    Schiller, J.H.5    Dowlati, A.6
  • 52
    • 64049115311 scopus 로고    scopus 로고
    • The differential efficacy of pemetrexed according to NSCLC histology: a review of two Phase III studies
    • Scagliotti G., Hanna N., Fossella F., Sugarmark K., Blatter J., Peterson P., et al. The differential efficacy of pemetrexed according to NSCLC histology: a review of two Phase III studies. Oncologist 2009, 14:253-263.
    • (2009) Oncologist , vol.14 , pp. 253-263
    • Scagliotti, G.1    Hanna, N.2    Fossella, F.3    Sugarmark, K.4    Blatter, J.5    Peterson, P.6
  • 53
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti G.V., Parikh P., von Pawel J., Biesma B., Vanseenkiste J., Manegold C., et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008, 26:3543-3551.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    von Pawel, J.3    Biesma, B.4    Vanseenkiste, J.5    Manegold, C.6
  • 55
    • 35048875691 scopus 로고    scopus 로고
    • Evaluation of HIF-1 inhibitors as anticancer agents
    • Semenza G.L. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today 2007, 12:853-859.
    • (2007) Drug Discov Today , vol.12 , pp. 853-859
    • Semenza, G.L.1
  • 56
    • 33750082400 scopus 로고    scopus 로고
    • Targeting tumor-associated carbonic anhydrase IX in cancer therapy
    • Thiry A., Dogne J.M., Masereel B., Supuran C.T. Targeting tumor-associated carbonic anhydrase IX in cancer therapy. Trends Pharmacol Sci 2006, 27:566-573.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 566-573
    • Thiry, A.1    Dogne, J.M.2    Masereel, B.3    Supuran, C.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.