Serrated and non-serrated precursor lesions of colorectal cancer

Digestive Diseases

Volumn 33, Issue 1, 2014, Pages 28-37

  Langner, Cord ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Adenocarcinoma; Colon; Histology; Molecular pathology; Rectum; Sessile serrated adenoma; Traditional serrated adenoma; Tubular adenoma; Tubulovillous adenoma; Villous adenoma

Indexed keywords

ADENOMATOUS POLYP; CANCER GROWTH; COLORECTAL ADENOMA; COLORECTAL CANCER; HUMAN; HYPERPLASTIC POLYP; INTESTINE POLYP; POLYPOSIS; RECTUM ADENOMA; REVIEW; SERRATED POLYPOSIS; ADENOMA; COLORECTAL TUMOR; DISEASE COURSE; HYPERPLASIA; PATHOLOGY; PRECANCER;

ADENOMA; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; HUMANS; HYPERPLASIA; INTESTINAL POLYPS; PRECANCEROUS CONDITIONS;

EID: 84919815935     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000366032     Document Type: Review

References (56)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
2. Samadder NJ, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ: Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older women. Gastroenterology 2013; 145: 348-356.
3. Leggett B, Whitehall V: Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology 2010; 138: 2088-2100.
4. Hamilton SR, Bosman FT, Boffetta P, Ilyas M, Morreau H, Nakamura SI, Quirke P, Riboli E, Sobin LH: Carcinoma of the colon and rectum; in Bosman FT, Carneiro F, Hruban RH, Theise ND (eds): WHO Classification of Tumours of the Digestive System, ed 4. Lyon, IARC, 2010, pp 134-146.
5. Rubio CA, Jaramillo E: Advanced microtubular colorectal adenomas: a 10-year survey at a single hospital. Anticancer Res 2013; 33: 5471-5476.
6. Rex DK: Maximizing detection of adenomas and cancers during colonoscopy. Am J Gastroenterol 2006; 101: 2866-2877.
7. Dik VK, Moons LM, Siersema PD: Endoscopic innovations to increase the adenoma detection rate during colonoscopy. World J Gastroenterol 2014; 20: 2200-2211.
8. Kudo Se, Lambert R, Allen JI, et al: Nonpolypoid neoplastic lesions of the colorectal mucosa. Gastrointest Endosc 2008; 68:S3-S47.
9. Lambert R, Kudo SE, Vieth M, et al: Pragmatic classification of superficial neoplastic colorectal lesions. Gastrointest Endosc 2009; 70: 1182-1199.
10. Hurlstone DP, Cross SS, Drew K, Adam I, Shorthouse AJ, Brown S, Sanders DS, Lobo AJ: An evaluation of colorectal endoscopic mucosal resection using high-magnification chromoscopic colonoscopy: a prospective study of 1,000 colonoscopies. Endoscopy 2004; 36: 491-498.
11. Parra-Blanco A, Gimeno-García AZ, Nicolás- Pérez D, García C, Medina C, Díaz-Flores L, Grosso B, Jiménez A, Quintero E: Risk for high-grade dysplasia or invasive carcinoma in colorectal flat adenomas in a Spanish population. Gastroenterol Hepatol 2006; 29: 602-609.
12. Kim BC, Chang HJ, Han KS, Sohn DK, Hong CW, Park JW, Park SC, Choi HS, Oh JH: Clinicopathological differences of laterally spreading tumors of the colorectum according to gross appearance. Endoscopy 2011; 43: 100-107.
13. Kaku E, Oda Y, Murakami Y, Goto H, Tanaka T, Hasuda K, Yasunaga M, Ito K, Sakurai K, Fujimori T, Hattori M, Sasaki Y: Proportion of flat- and depressed-type and laterally spreading tumor among advanced colorectal neoplasia. Clin Gastroenterol Hepatol 2011; 9: 503-508.
14. Reinhart K, Bannert C, Dunkler D, Salzl P, Trauner M, Renner F, Knoflach P, Ferlitsch A, Weiss W, Ferlitsch M: Prevalence of flat lesions in a large screening population and their role in colonoscopy quality improvement. Endoscopy 2013; 45: 350-356.
15. Hassan C, Quintero E, Dumonceau JM, Regula J, Brandão C, Chaussade S, Dekker E, Dinis-Ribeiro M, Ferlitsch M, Gimeno-García A, Hazewinkel Y, Jover R, Kalager M, Loberg M, Pox C, Rembacken B, Lieberman D: Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2013; 45: 842-851.
16. Spring KJ, Zhao ZZ, Karamatic R, Walsh MD, Whitehall VL, Pike T, Simms LA, Young J, James M, Montgomery GW, Appleyard M, Hewett D, Togashi K, Jass JR, Leggett BA: High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology 2006; 131: 1400-1407.
17. Lash RH, Genta RM, Schuler CM: Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients. J Clin Pathol 2010; 63: 681-686.
18. Hazewinkel Y, de Wijkerslooth TR, Stoop EM, Bossuyt PM, Biermann K, van de Vijver MJ, Fockens P, van Leerdam ME, Kuipers EJ, Dekker E: Prevalence of serrated polyps and association with synchronous advanced neoplasia in screening colonoscopy. Endoscopy 2014; 46: 219-224.
19. Radtke F, Clevers H: Self-renewal and cancer of the gut: two sides of a coin. Science. 2005; 307: 1904-1909.
20. Humphries A, Wright NA: Colonic crypt organization and tumorigenesis. Nat Rev Cancer 2008; 8: 415-424.
21. Brabletz S, Schmalhofer O, Brabletz T: Gastrointestinal stem cells in development and cancer. J Pathol 2009; 217: 307-317.
22. Zeki SS, Graham TA, Wright NA: Stem cells and their implications for colorectal cancer. Nat Rev Gastroenterol Hepatol 2011; 8: 90-100.
23. MacDonald BT, Tamai K, He X: Wnt/β- catenin signaling: components, mechanisms, and diseases. Dev Cell 2009; 17: 9-26.
24. Reya T, Clevers H: Wnt signalling in stem cells and cancer. Nature 2005; 434: 843-850.
25. White BD, Chien AJ, Dawson DW: Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology 2012; 142: 219-232.
26. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW: APC mutations occur early during colorectal tumorigenesis. Nature 1992; 359: 235-237.
27. Hanson CA, Miller JR: Non-traditional roles for the adenomatous polyposis coli (APC) tumor suppressor protein. Gene 2005; 361: 1-12.
28. Pino MS, Chung DC: The chromosomal instability pathway in colon cancer. Gastroenterology 2010; 138: 2059-2072.
29. Takayama T, Ohi M, Hayashi T, Miyanishi K, Nobuoka A, Nakajima T, Satoh T, Takimoto R, Kato J, Sakamaki S, Niitsu Y: Analysis of K-ras, APC, and β-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology 2001; 121: 599-611.
30. Esteller M, Sparks A, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Gonzalez S, Tarafa G, Sidransky D, Meltzer SJ, Baylin SB, Herman JG: Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 2000; 60: 4366-4371.
31. Novelli MR, Williamson JA, Tomlinson IP, Elia G, Hodgson SV, Talbot IC, Bodmer WF, Wright NA: Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. Science 1996; 272: 1187-1190.
32. Vasen HF, Blanco I, Aktan-Collan K, et al; Mallorca group: Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Gut 2013; 62: 812-823.
33. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-767.
34. Wood LD, Parsons DW, Jones S, et al: The genomic landscapes of human breast and colorectal cancers. Science 2007; 318: 1108-1113.
35. Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, Parsons DW, Jones S, Sjöblom T, Park BH, Parsons R, Willis J, Dawson D, Willson JK, Nikolskaya T, Nikolsky Y, Kopelovich L, Papadopoulos N, Pennacchio LA, Wang TL, Markowitz SD, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE: Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci USA 2008; 105: 16224-16229.
36. Lengauer C, Kinzler KW, Vogelstein B: Genetic instabilities in human cancers. Nature 1998; 396: 643-649.
37. Giardiello FM, Burt RW, Järvinen HJ, Offerhaus GJ: Familial adenomatous polyposis; in Bosman FT, Carneiro F, Hruban RH, Theise ND (eds): WHO Classification of Tumours of the Digestive System, ed 4. Lyon, IARC, 2010, pp 147-151.
38. Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hedge P, McKechnie D, et al: Identification of FAP locus genes from chromosome 5q21. Science 1991; 253: 661-665.
39. Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991; 253: 665-669.
40. Fearon ER: Molecular genetics of colorectal cancer. Annu Rev Pathol 2011; 6: 479-507.
41. Snover DC, Ahnen DJ, Burt RW, Odze RD: Serrated polyps of the colon and rectum and serrated polyposis; in Bosman FT, Carneiro F, Hruban RH, Theise ND (eds): WHO Classification of Tumours of the Digestive System, ed 4. Lyon, IARC, 2010, pp 160-165.
42. Snover DC: Update on the serrated pathway to colorectal carcinoma. Hum Pathol 2011; 42: 1-10.
43. Bettington M, Walker N, Clouston A, Brown I, Leggett B, Whitehall V: The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology 2013; 62: 367-386.
44. Rex DK, Ahnen DJ, Baron JA, Batts KP, Burke CA, Burt RW, Goldblum JR, Guillem JG, Kahi CJ, Kalady MF, O'Brien MJ, Odze RD, Ogino S, Parry S, Snover DC, Torlakovic EE, Wise PE, Young J, Church J: Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol 2012; 107: 1315-1329.
45. Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ: BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol 2004; 28: 1452-1459.
46. Yano T, Sano Y, Iwasaki J, Fu KI, Yoshino T, Kato S, Mera K, Ochiai A, Fujii T, Yoshida S: Distribution and prevalence of colorectal hyperplastic polyps using magnifying pan-mucosal chromoendoscopy and its relationship with synchronous colorectal cancer: prospective study. J Gastroenterol Hepatol 2005; 20: 1572-1577.
47. Torlakovic E, Snover DC: Serrated adenomatous polyposis in humans. Gastroenterology 1996; 110: 748-755.
48. Tadepalli US, Feihel D, Miller KM, Itzkowitz SH, Freedman JS, Kornacki S, Cohen LB, Bamji ND, Bodian CA, Aisenberg J: A morphologic analysis of sessile serrated polyps observed during routine colonoscopy (with video). Gastrointest Endosc 2011; 74: 1360-1368.
49. Hazewinkel Y, López-Cerón M, East JE, Rastogi A, Pellisé M, Nakajima T, van Eeden S, Tytgat KM, Fockens P, Dekker E: Endoscopic features of sessile serrated adenomas: validation by international experts using high-resolution white-light endoscopy and narrowband imaging. Gastrointest Endosc 2013; 77: 916-924.
50. Ensari A, Bilezikçi B, Carneiro F, Doʇusoy GB, Driessen A, Dursun A, Flejou JF, Geboes K, de Hertogh G, Jouret-Mourin A, Langner C, Nagtegaal ID, Offerhaus J, Orlowska J, Ristimäki A, Sanz-Ortega J, Savaş B, Sotiropoulou M, Villanacci V, Kurşun N, Bosman F: Serrated polyps of the colon: how reproducible is their classification? Virchows Arch 2012; 461: 495-504.
51. Sawhney MS, Farrar WD, Gudiseva S, Nelson DB, Lederle FA, Rector TS, Bond JH: Microsatellite instability in interval colon cancers. Gastroenterology 2006; 131: 1700-1705.
52. Arain MA, Sawhney M, Sheikh S, Anway R, Thyagarajan B, Bond JH, Shaukat A: CIMP status of interval colon cancers: another piece to the puzzle. Am J Gastroenterol 2010; 105: 1189-1195.
53. Torlakovic EE, Gomez JD, Driman DK, Parfitt JR, Wang C, Benerjee T, Snover DC: Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol 2008; 32: 21-29.
54. Guarinos C, Sánchez-Fortún C, Rodríguez- Soler M, et al: Clinical subtypes and molecular characteristics of serrated polyposis syndrome. Clin Gastroenterol Hepatol 2013; 11: 705-711.
55. Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC: Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. Gastroenterology 2014; 146: 520-529.
56. Hazewinkel Y, Tytgat KM, van Eeden S, Bastiaansen B, Tanis PJ, Boparai KS, Fockens P, Dekker E: Incidence of colonic neoplasia in patients with serrated polyposis syndrome who undergo annual endoscopic surveillance. Gastroenterology 2014; 147: 88-95.