Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas

Gastroenterology

Volumn 146, Issue 2, 2014, Pages

  Gala, Manish K ^a   Mizukami, Yusuke ^a,b,c   Le, Long P ^a   Moriichi, Kentaro ^a   Austin, Thomas ^a   Yamamoto, Masayoshi ^a   Lauwers, Gregory Y ^a   Bardeesy, Nabeel ^b   Chung, Daniel C ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Sapporo Higashi Tokushukai Hospital   (Japan)

Author keywords

Hereditary Colon Cancer; RNF43; Serrated Polyposis Syndrome; Sessile Serrated Polyp

Indexed keywords

ATM PROTEIN; ATR PROTEIN;

ADULT; ARTICLE; ATM GENE; BIOINFORMATICS; CONTROLLED STUDY; DNA DAMAGE; EXOME; FEMALE; GENE FUNCTION; GENE SEQUENCE; GENE SILENCING; GENETIC ASSOCIATION; GENETIC RISK; GENOMICS; GENOTYPE; HUMAN; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; MOLECULAR MECHANICS; MUTATIONAL ANALYSIS; NONSENSE MUTATION; ONCOGENE; PANCREAS CELL; PANCREAS DUCT; PIF1 GENE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RBL1 GENE; RECTUM ADENOMA; RECTUM POLYP; SENESCENCE; TELO2 GENE; ULTRAVIOLET RADIATION; XAF1 GENE;

ADENOMATOUS POLYPS; ADULT; AGED; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CASE-CONTROL STUDIES; CELL AGING; CODON, NONSENSE; COLONIC NEOPLASMS; DNA HELICASES; DNA-BINDING PROTEINS; EXOME; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; GERM-LINE MUTATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; ONCOGENE PROTEINS; PRECANCEROUS CONDITIONS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-ETS; RAS PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P107; SEQUENCE ANALYSIS, DNA;

EID: 84892694924     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.10.045     Document Type: Article

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