Immune cell therapy in IBD

Digestive Diseases

Volumn 32, Issue , 2014, Pages 61-66

  Dunkin, David ^a   Mehandru, Saurabh ^a   Colombel, Jean Frédéric ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Crohn's disease; Gastrointestinal inflammation; Regulatory T cells

Indexed keywords

ANTIGEN; CD4 ANTIGEN; COLON EXTRACTED PROTEIN; CYTOKINE; OVALBUMIN; PROTEIN; RETINOIC ACID; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ARTICLE; BYSTANDER EFFECT; CELL HOMING; CELL THERAPY; CLINICAL EFFECTIVENESS; COLITIS; CROHN DISEASE; DENDRITIC CELL; DIGESTIVE SYSTEM INFLAMMATION; EX VIVO STUDY; GASTROINTESTINAL TRACT; HUMAN; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; IN VIVO STUDY; INFLAMMATORY BOWEL DISEASE; INFLUENZA VIRUS A H1N1; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); REGULATORY T LYMPHOCYTE; SAFETY; TH17 CELL; TRANSDERMAL PATCH; ANIMAL; BIOLOGICAL THERAPY; IMMUNOLOGY; LYMPHOCYTE;

ANIMALS; CELL- AND TISSUE-BASED THERAPY; CROHN DISEASE; HUMANS; LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 84919815924     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000367827     Document Type: Article

References (41)

1. van der Zaag-Loonen HJ, Casparie M, Taminiau JA, Escher JC, Pereira RR, Derkx HH: The incidence of pediatric inflammatory bowel disease in the Netherlands: 1999-2001. J Pediatr Gastroenterol Nutr 2004; 38: 302-307.
2. Benchimol EI, Fortinsky KJ, Gozdyra P, Van den Heuvel M, Van Limbergen J, Griffiths AM: Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis 2011; 17: 423-439.
3. Benchimol EI, Guttmann A, Griffiths AM, Rabeneck L, Mack DR, Brill H, et al: Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data. Gut 2009; 58: 1490-1497.
4. Maul J, Loddenkemper C, Mundt P, Berg E, Giese T, Stallmach A, et al: Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology 2005; 128: 1868-1878.
5. Kraus TA, Cheifetz A, Toy L, Meddings JB, Mayer L: Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease. Inflamm Bowel Dis 2006; 12: 82-88, discussion 81.
6. Kraus TA, Toy L, Chan L, Childs J, Mayer L: Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease. Gastroenterology 2004; 126: 1771-1778.
7. Buckner JH: Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol 2010; 10: 849-859.
8. Schaefer ME, Machan JT, Kawatu D, Langton CR, Markowitz J, Crandall W, et al: Factors that determine risk for surgery in pediatric patients with Crohn's disease. Clin Gastroenterol Hepatol 2010; 8: 789-794.
9. Roncarolo MG, Gregori S, Battaglia M, Bacchetta R, Fleischhauer K, Levings MK: Interleukin- 10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev 2006; 212: 28-50.
10. Faria AM, Weiner HL: Oral tolerance and TGF-beta-producing cells. Inflamm Allergy Drug Targets 2006; 5: 179-190.
11. Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, et al: Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 2002; 3: 237-243.
12. Kronenberg M: Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 2005; 23: 877-900.
13. Zhang ZX, Yang L, Young KJ, DuTemple B, Zhang L: Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 2000; 6: 782-789.
14. Hayday A, Tigelaar R: Immunoregulation in the tissues by gammadelta T cells. Nat Rev Immunol 2003; 3: 233-242.
15. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-1164.
16. Maloy KJ, Antonelli LR, Lefevre M, Powrie F: Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells. Immunol Lett 2005; 97: 189-192.
17. Mottet C, Uhlig HH, Powrie F: Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003; 170: 3939-3943.
18. Desreumaux P, Foussat A, Allez M, Beaugerie L, Hebuterne X, Bouhnik Y, et al: Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease. Gastroenterology 2012; 143: 1207-1217.e1-2.
19. Hammerschmidt SI, Friedrichsen M, Boelter J, Lyszkiewicz M, Kremmer E, Pabst O, et al: Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice. J Clin Invest 2011; 121: 3051-3061.
20. Zhou X, Kong N, Wang J, Fan H, Zou H, Horwitz D, et al: Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu. J Immunol 2010; 185: 2675-2679.
21. Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy R, et al: Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med 2010; 207: 553-564.
22. Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, et al: Control of TH17 cells occurs in the small intestine. Nature 2011; 475: 514-518.
23. Ciabattini A, Pettini E, Fiorino F, Prota G, Pozzi G, Medaglini D: Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice. PLoS One 2011; 6:e19346.
24. Zhou P, Borojevic R, Streutker C, Snider D, Liang H, Croitoru K: Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens. J Immunol 2004; 172: 1515-1523.
25. Mori K, Yamanishi H, Ikeda Y, Kumagi T, Hiasa Y, Matsuura B, et al: Oral administration of carbonic anhydrase I ameliorates murine experimental colitis induced by Foxp3- CD4+CD25- T cells. J Leukoc Biol 2013; 93: 963-972.
26. Yue M, Shen Z, Yu CH, Ye H, Li YM: The therapeutic role of oral tolerance in dextran sulfate sodium-induced colitis via Th1-Th2 balance and γδ T cells. J Dig Dis 2013; 14: 543-551.
27. Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, et al: A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389: 737-742.
28. Cong Y, Weaver CT, Lazenby A, Elson CO: Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J Immunol 2002; 169: 6112-6119.
29. Shan-Shan Z, Yu-Lan L: Therapeutic effects of mucosal tolerance on experimental colitis in rats. Eur J Gastroenterol Hepatol 2009; 21: 1145-1152.
30. Monetini L, Cavallo MG, Sarugeri E, Sentinelli F, Stefanini L, Bosi E, et al: Cytokine profile and insulin antibody IgG subclasses in patients with recent onset type 1 diabetes treated with oral insulin. Diabetologia 2004; 47: 1795-1802.
31. Koffeman EC, Genovese M, Amox D, Keogh E, Santana E, Matteson EL, et al: Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial. Arthritis Rheum 2009; 60: 3207-3216.
32. McKown KM, Carbone LD, Bustillo J, Seyer JM, Kang AH, Postlethwaite AE: Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen. Arthritis Rheum 2000; 43: 1054-1061.
33. Margalit M, Israeli E, Shibolet O, Zigmond E, Klein A, Hemed N, et al: A double-blind clinical trial for treatment of Crohn's disease by oral administration of Alequel, a mixture of autologous colon-extracted proteins: a patient- tailored approach. Am J Gastroenterol 2006; 101: 561-568.
34. Ruane D, Brane L, Reis BS, Cheong C, Poles J, Do Y, et al: Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J Exp Med 2013; 210: 1871-1888.
35. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY: Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004; 21: 527-538.
36. Azukizawa H, Dohler A, Kanazawa N, Nayak A, Lipp M, Malissen B, et al: Steady state migratory RelB(+) langerin(+) dermal dendritic cells mediate peripheral induction of antigenspecific CD4(+) CD25(+) Foxp3(+) regulatory T cells. Eur J Immunol 2011; 41: 1420-1434.
37. Mondoulet L, Dioszeghy V, Ligouis M, Dhelft V, Dupont C, Benhamou PH: Epicutaneous immunotherapy on intact skin using a new delivery system in a murine model of allergy. Clin Exp Allergy 2010; 40: 659-667.
38. Mondoulet L, Dioszeghy V, Vanoirbeek JA, Nemery B, Dupont C, Benhamou PH: Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts. Int Arch Allergy Immunol 2011; 154: 299-309.
39. Dioszeghy V, Mondoulet L, Dhelft V, Ligouis M, Puteaux E, Benhamou PH, et al: Epicutaneous immunotherapy results in rapid allergen uptake by dendritic cells through intact skin and downregulates the allergen-specific response in sensitized mice. J Immunol 2011; 186: 5629-5637.
40. Mondoulet L, Dioszeghy V, Larcher T, Ligouis M, Dhelft V, Puteaux E, et al: Epicutaneous immunotherapy (EPIT) blocks the allergic esophago-gastro-enteropathy induced by sustained oral exposure to peanuts in sensitized mice. PLoS One 2012; 7:e31967.
41. Dunkin D, Berin MC, Mayer L: Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner. J Allergy Clin Immunol 2011; 128: 1251-1258.e2.