Direct activation of ribosome-associated double-stranded rna-dependent protein kinase (PKR) by deoxynivalenol, anisomycin and ricin: A new model for ribotoxic stress response induction

Toxins

Volumn 6, Issue 12, 2014, Pages 3406-3425

  Zhou, Hui Ren ^a   He, Kaiyu ^b,c   Landgraf, Jeff ^c   Pan, Xiao ^c,d   Pestka, James J ^a,b,c  

^a Michigan State University   (United States)

^b Department of Microbiology and Molecular Genetics Michigan State University ^*  (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d Michigan State University   (United States)

Author keywords

Anisomycin; Deoxynivalenol; PKR; Quantitiative Western analysis; Ribotoxic stress; Ricin; RNA immunoprecipitation; RRNA; Translational inhibitor

Indexed keywords

ANISOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDYLTRANSFERASE; PROTEIN KINASE R; RIBONUCLEASE; RIBOSOME RNA; RICIN; RNA 28S; SYNAPTOPHYSIN; VOMITOXIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN SYNTHESIS INHIBITOR; RNA 18S; TRICHOTHECENE DERIVATIVE;

APOPTOSIS; ARTICLE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR CLONING; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RIBOTOXIC STRESS RESPONSE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STOICHIOMETRY; WESTERN BLOTTING; CHEMISTRY; GENETICS; METABOLISM; PHOSPHORYLATION; RIBOSOME;

ANISOMYCIN; CLONING, MOLECULAR; EIF-2 KINASE; HELA CELLS; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITORS; RIBOSOMES; RICIN; RNA, RIBOSOMAL, 18S; RNA, RIBOSOMAL, 28S; SEQUENCE ANALYSIS, RNA; TRICHOTHECENES;

EID: 84919792593     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins6123406     Document Type: Article

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