Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes

Toxicological Sciences

Volumn 115, Issue 2, 2010, Pages 444-452

  Bae, Heekyong ^a,b   Gray, Jennifer S ^a,c   Li, Maoxiang ^a,b   Vines, Laura ^a,b   Kim, Joon ^d   Pestka, James J ^a,b,c  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c NONE   (United States)

^d Korea University   (South Korea)

Author keywords

Deoxynivalenol (DON); Protein kinase; Ribosome; Translation

Indexed keywords

2 AMINOPURINE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; APOPTOSIS SIGNAL REGULATING KINASE 1; HEMATOPOIETIC CELL KINASE; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE R; RIBOSOME DNA; RIBOSOME DNA 40S; RIBOSOME PROTEIN; RIBOSOME PROTEIN S3; SUCROSE; SYNAPTOPHYSIN; TRICHOTHECENE DEOXYNIVALENOL; TRICHOTHECENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTISENSE VECTOR; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN U937; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RIBOSOME; RIBOTOXIC STRESS; SIGNAL TRANSDUCTION; STRESS; WESTERN BLOTTING;

ANIMALS; EIF-2 KINASE; ENZYME ACTIVATION; ENZYME INHIBITORS; HELA CELLS; HUMANS; INTERLEUKIN-8; MACROPHAGES, PERITONEAL; MICE; MONONUCLEAR PHAGOCYTE SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHAGOCYTES; PROTO-ONCOGENE PROTEINS C-HCK; PYRIMIDINES; RIBOSOMAL PROTEINS; RIBOSOME SUBUNITS, SMALL, EUKARYOTIC; TRICHOTHECENES; U937 CELLS;

EUKARYOTA; MURINAE; MUS;

EID: 77954075387     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq055     Document Type: Article

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