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Volumn 145, Issue 1, 2015, Pages 32-40

In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency

Author keywords

Biomarkers; Biotin; Carnitine; Intermediary metabolism; Mass spectrometry

Indexed keywords

ACETYLCARNITINE; ACYL COENZYME A; ACYLCARNITINE; BIOTIN; CARBOXYLASE; CARNITINE; METHYLMALONYLCARNITINE; PROPIONYLCARNITINE; UNCLASSIFIED DRUG; 3-HYDROXYISOVALERYLCARNITINE; BIOLOGICAL MARKER; CULTURE MEDIUM;

EID: 84919781296     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.201343     Document Type: Article
Times cited : (2)

References (36)
  • 3
    • 58649103991 scopus 로고    scopus 로고
    • Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in the mouse
    • Mock DM. Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in the mouse. J Nutr 2009;139:154-7.
    • (2009) J Nutr , vol.139 , pp. 154-157
    • Mock, D.M.1
  • 4
    • 0033044528 scopus 로고    scopus 로고
    • Biotin bioavailability and estimated average requirement: why bother?
    • Said HM. Biotin bioavailability and estimated average requirement: why bother? Am J Clin Nutr 1999;69:352-3.
    • (1999) Am J Clin Nutr , vol.69 , pp. 352-353
    • Said, H.M.1
  • 7
    • 24344462272 scopus 로고    scopus 로고
    • Pregnancy increases urinary loss of carnitine and reduces plasma carnitine in Korean women
    • Cho S, Cha Y. Pregnancy increases urinary loss of carnitine and reduces plasma carnitine in Korean women. Br J Nutr 2005;93(5):685-91.
    • (2005) Br J Nutr , vol.93 , Issue.5 , pp. 685-691
    • Cho, S.1    Cha, Y.2
  • 8
    • 70249093588 scopus 로고    scopus 로고
    • Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration
    • Keller U, van der Wal C, Seliger G, Scheler C, Ropke F, Eder K. Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration. Eur J Clin Nutr 2009;63:1098-105.
    • (2009) Eur J Clin Nutr , vol.63 , pp. 1098-1105
    • Keller, U.1    van der Wal, C.2    Seliger, G.3    Scheler, C.4    Ropke, F.5    Eder, K.6
  • 9
    • 77951112808 scopus 로고    scopus 로고
    • Low availability of carnitine precursors as a possible reason for the diminished plasma carnitine concentrations in pregnant women
    • Ringseis R, Hanisch N, Seliger G, Eder K. Low availability of carnitine precursors as a possible reason for the diminished plasma carnitine concentrations in pregnant women. BMC Pregnancy Childbirth 2010;10:10-7.
    • (2010) BMC Pregnancy Childbirth , vol.10 , pp. 10-17
    • Ringseis, R.1    Hanisch, N.2    Seliger, G.3    Eder, K.4
  • 10
    • 84866265452 scopus 로고    scopus 로고
    • Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans
    • Bogusiewicz A, Horvath TD, Stratton SL, Mock DM, Boysen G. Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans. J Nutr 2012;142:1621-5.
    • (2012) J Nutr , vol.142 , pp. 1621-1625
    • Bogusiewicz, A.1    Horvath, T.D.2    Stratton, S.L.3    Mock, D.M.4    Boysen, G.5
  • 11
    • 60449118306 scopus 로고    scopus 로고
    • Carnitine deficiency: a possible risk factor in paracetamol hepatotoxicity
    • Arafa HM. Carnitine deficiency: a possible risk factor in paracetamol hepatotoxicity. Arch Toxicol 2009;83:139-50.
    • (2009) Arch Toxicol , vol.83 , pp. 139-150
    • Arafa, H.M.1
  • 12
    • 32644477036 scopus 로고    scopus 로고
    • Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model
    • Al-Majed AA, Sayed-Ahmed MM, Al-Yahya AA, Aleisa AM, Al-Rejaie SS, Al-Shabanah OA. Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. Pharmacol Res 2006;53(3):278-86.
    • (2006) Pharmacol Res , vol.53 , Issue.3 , pp. 278-286
    • Al-Majed, A.A.1    Sayed-Ahmed, M.M.2    Al-Yahya, A.A.3    Aleisa, A.M.4    Al-Rejaie, S.S.5    Al-Shabanah, O.A.6
  • 13
    • 0037237752 scopus 로고    scopus 로고
    • Mechanisms of liver steatosis in rats with systemic carnitine deficiency due to treatment with trimethylhydraziniumpropionate
    • Spaniol M, Kaufmann P, Beier K, Wuthrich J, Torok M, Scharnagl H, Marz W, Krahenbuhl S. Mechanisms of liver steatosis in rats with systemic carnitine deficiency due to treatment with trimethylhydraziniumpropionate. J Lipid Res 2003;44:144-53.
    • (2003) J Lipid Res , vol.44 , pp. 144-153
    • Spaniol, M.1    Kaufmann, P.2    Beier, K.3    Wuthrich, J.4    Torok, M.5    Scharnagl, H.6    Marz, W.7    Krahenbuhl, S.8
  • 15
    • 0022498810 scopus 로고
    • Plasma carnitine and renal-carnitine clearance during pregnancy
    • Cederblad G, Fahraeus L, Lindgren K. Plasma carnitine and renal-carnitine clearance during pregnancy. Am J Clin Nutr 1986;44:379-83.
    • (1986) Am J Clin Nutr , vol.44 , pp. 379-383
    • Cederblad, G.1    Fahraeus, L.2    Lindgren, K.3
  • 16
    • 0037117547 scopus 로고    scopus 로고
    • Holocarboxylase synthetase is an obligate participant in biotin-mediated regulation of its own expression and of biotin-dependent carboxylases mRNA levels in human cells
    • Solórzano-Vargas RS, Pacheco-Alvarez D, Leon-Del-Rio A. Holocarboxylase synthetase is an obligate participant in biotin-mediated regulation of its own expression and of biotin-dependent carboxylases mRNA levels in human cells. Proc Natl Acad Sci USA 2002;99:5325-30.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5325-5330
    • Solórzano-Vargas, R.S.1    Pacheco-Alvarez, D.2    Leon-Del-Rio, A.3
  • 17
    • 77952650770 scopus 로고    scopus 로고
    • Biotin requirements are lower in human Jurkat lymphoid cells but homeostatic mechanisms are similar to those of HepG2 liver cells
    • Mall GK, Chew YC, Zempleni J. Biotin requirements are lower in human Jurkat lymphoid cells but homeostatic mechanisms are similar to those of HepG2 liver cells. J Nutr 2010;140:1086-92.
    • (2010) J Nutr , vol.140 , pp. 1086-1092
    • Mall, G.K.1    Chew, Y.C.2    Zempleni, J.3
  • 18
    • 18344367711 scopus 로고    scopus 로고
    • Marginal maternal biotin deficiency in CD-1 mice reduces fetal mass of biotin-dependent carboxylases
    • Sealey WM, Stratton SL, Mock DM, Hansen DK. Marginal maternal biotin deficiency in CD-1 mice reduces fetal mass of biotin-dependent carboxylases. J Nutr 2005;135:973-7.
    • (2005) J Nutr , vol.135 , pp. 973-977
    • Sealey, W.M.1    Stratton, S.L.2    Mock, D.M.3    Hansen, D.K.4
  • 19
    • 0031418673 scopus 로고    scopus 로고
    • Determinations of biotin in biological fluids
    • McCormick DB, Suttie JW, Wagner C, editors, New York: Academic Press
    • Mock DM. Determinations of biotin in biological fluids. In: McCormick DB, Suttie JW, Wagner C, editors. Methods in enzymology. New York: Academic Press; 1997. p. 265-75.
    • (1997) Methods in enzymology , pp. 265-275
    • Mock, D.M.1
  • 21
    • 79954986233 scopus 로고    scopus 로고
    • Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma
    • Jones DR, Boysen G, Miller GP. Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2011;879:1056-62.
    • (2011) J Chromatogr B Analyt Technol Biomed Life Sci , vol.879 , pp. 1056-1062
    • Jones, D.R.1    Boysen, G.2    Miller, G.P.3
  • 22
    • 0034066252 scopus 로고    scopus 로고
    • Marginal biotin deficiency is teratogenic
    • Zempleni J, Mock D. Marginal biotin deficiency is teratogenic. Proc Soc Exp Biol Med 2000;223:14-21.
    • (2000) Proc Soc Exp Biol Med , vol.223 , pp. 14-21
    • Zempleni, J.1    Mock, D.2
  • 23
    • 0030903118 scopus 로고    scopus 로고
    • Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased status in experimental biotin deficiency
    • Mock NI, Malik MI, Stumbo PJ, Bishop WP, Mock DM. Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased status in experimental biotin deficiency. Am J Clin Nutr 1997;65:951-8.
    • (1997) Am J Clin Nutr , vol.65 , pp. 951-958
    • Mock, N.I.1    Malik, M.I.2    Stumbo, P.J.3    Bishop, W.P.4    Mock, D.M.5
  • 24
    • 0036828376 scopus 로고    scopus 로고
    • Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge
    • Mock DM, Henrich CL, Carnell N, Mock NI. Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge. Am J Clin Nutr 2002;76:1061-8.
    • (2002) Am J Clin Nutr , vol.76 , pp. 1061-1068
    • Mock, D.M.1    Henrich, C.L.2    Carnell, N.3    Mock, N.I.4
  • 25
    • 34250832112 scopus 로고    scopus 로고
    • Determination of carnitine ester patterns during the second half of pregnancy, at delivery, and in neonatal cord blood by tandem mass spectrometry: complex and dynamic involvement of carnitine in the intermediary metabolism
    • Talián GC, Komlosi K, Decsi T, Koletzko B, Melegh B. Determination of carnitine ester patterns during the second half of pregnancy, at delivery, and in neonatal cord blood by tandem mass spectrometry: complex and dynamic involvement of carnitine in the intermediary metabolism. Pediatr Res 2007;62:88-92.
    • (2007) Pediatr Res , vol.62 , pp. 88-92
    • Talián, G.C.1    Komlosi, K.2    Decsi, T.3    Koletzko, B.4    Melegh, B.5
  • 26
    • 0027049235 scopus 로고
    • Carnitine function and requirements during the life cycle
    • Rebouche CJ. Carnitine function and requirements during the life cycle. FASEB J 1992;6(15):3379-86.
    • (1992) FASEB J , vol.6 , Issue.15 , pp. 3379-3386
    • Rebouche, C.J.1
  • 29
    • 0021362187 scopus 로고
    • Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes: evidence for alterations in tissue carnitine transport
    • Rebouche CJ, Engel AG. Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes: evidence for alterations in tissue carnitine transport. J Clin Invest 1984;73:857-67.
    • (1984) J Clin Invest , vol.73 , pp. 857-867
    • Rebouche, C.J.1    Engel, A.G.2
  • 30
    • 77952505194 scopus 로고    scopus 로고
    • Quantitative measurement of plasma 3-hydroxyisovaleryl carnitine by LC-MS/MS as a novel biomarker of biotin status in humans
    • Horvath TD, Stratton SL, Bogusiewicz A, Pack L, Moran J, Mock DM. Quantitative measurement of plasma 3-hydroxyisovaleryl carnitine by LC-MS/MS as a novel biomarker of biotin status in humans. Anal Chem 2010;82:4140-4.
    • (2010) Anal Chem , vol.82 , pp. 4140-4144
    • Horvath, T.D.1    Stratton, S.L.2    Bogusiewicz, A.3    Pack, L.4    Moran, J.5    Mock, D.M.6
  • 31
    • 81055126892 scopus 로고    scopus 로고
    • Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans
    • Mock DM, Stratton S, Horvath T, Bogusiewicz A, Matthews N, Henrich CL, Dawson AM, Spencer HJ, Owen SN, Boysen G, et al. Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans. J Nutr 2011;141:1925-30.
    • (2011) J Nutr , vol.141 , pp. 1925-1930
    • Mock, D.M.1    Stratton, S.2    Horvath, T.3    Bogusiewicz, A.4    Matthews, N.5    Henrich, C.L.6    Dawson, A.M.7    Spencer, H.J.8    Owen, S.N.9    Boysen, G.10
  • 32
    • 0028584280 scopus 로고
    • Acylcarnitine profile in tissues and body fluids of biotin-deficient rats with and without L-carnitine supplementation
    • Shigematsu Y, Bykov IL, Liu YY, Nakai A, Kikawa Y, Sudo M, Fujioka M. Acylcarnitine profile in tissues and body fluids of biotin-deficient rats with and without L-carnitine supplementation. J Inherit Metab Dis 1994;17:678-90.
    • (1994) J Inherit Metab Dis , vol.17 , pp. 678-690
    • Shigematsu, Y.1    Bykov, I.L.2    Liu, Y.Y.3    Nakai, A.4    Kikawa, Y.5    Sudo, M.6    Fujioka, M.7
  • 33
    • 0028066924 scopus 로고
    • Moderate carnitine depletion and long-chain fatty acid oxidation, exercise capacity, and nitrogen balance in the rat
    • Heinonen OJ, Takala J. Moderate carnitine depletion and long-chain fatty acid oxidation, exercise capacity, and nitrogen balance in the rat. Pediatr Res 1994;36:288-92.
    • (1994) Pediatr Res , vol.36 , pp. 288-292
    • Heinonen, O.J.1    Takala, J.2
  • 35
    • 0021710439 scopus 로고
    • Urinary excretion of L-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of L-carnitine
    • Chalmers RA, Roe CR, Stacey TE, Hoppel CL. Urinary excretion of L-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of L-carnitine. Pediatr Res 1984;18:1325-8.
    • (1984) Pediatr Res , vol.18 , pp. 1325-1328
    • Chalmers, R.A.1    Roe, C.R.2    Stacey, T.E.3    Hoppel, C.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.