Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model

Pharmacological Research

Volumn 53, Issue 3, 2006, Pages 278-286

  Al Majed, Abdulhakeem A ^a   Sayed Ahmed, Mohamed M ^a   Al Yahya, Abdulaziz A ^a   Aleisa, Abdulaziz M ^a   Al Rejaie, Salim S ^a   Al Shabanah, Othman A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Cardiomyopathy; Carnitine deficiency; Cisplatin; D carnitine; Proionyl L carnitine

Indexed keywords

ADENOSINE TRIPHOSPHATE; AZELASTINE; CARNITINE; CISPLATIN; CREATINE KINASE MB; GLUTATHIONE; LACTATE DEHYDROGENASE; NITRATE; NITRITE; PROPIONYLCARNITINE; SODIUM CHLORIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

AMINO ACID DEFICIENCY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CARDIOMYOPATHY; CARDIOVASCULAR RISK; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DISEASE COURSE; HEART; HEART INJURY; HEART MUSCLE; HEART PROTECTION; HISTOPATHOLOGY; ISOLATED HEART; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RISK FACTOR; TISSUE LEVEL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARDIOMYOPATHIES; CARNITINE; CISPLATIN; DISEASE MODELS, ANIMAL; GLUTATHIONE; HEART; MALE; MYOCARDIUM; NITRIC OXIDE; OXIDATIVE STRESS; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 32644477036     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phrs.2005.12.005     Document Type: Article

References (58)

1. P.J. Loehrer, and L.H. Einhom Cisplatin Ann Intern Med 100 1984 704 713
2. W. Lieberthal, V. Triaca, and J. Levine Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs necrosis Am J Physiol 240 1996 F700 F708
3. P.E. Kintzel Anticancer drug-induced kidney disorders Drug Saf 24 2001 19 38
4. G. Chvetzoff, B. Bonotte, and B. Chauffert Anticancer chemotherapy. Prevention of toxicity Presse Med 27 1998 2106 2112
5. V.B. Pai, and M.C. Nahata Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention Drug Saf 22 2000 263 302
6. S. Berliner, M. Rahima, Y. Sidi, Y. Teplitsky, Y. Zohar, and B. Nussbaum Acute coronary events following cisplatin-based chemotherapy Cancer Invest 8 1990 583 586
7. D. Tassinari, S. Sartori, G. Drudi, I. Panzini, L. Gianni, and E. Pasquini Cardiac arrythmias after cisplatin infusion: three case reports and a review of literature Ann Oncol 8 1997 1263 1267
8. S. Shanmugasundaram, R. Bharathithasan, and S. Elangovan 5-fluorouracil induced cardiotoxicity Indian Heart J 54 2002 86 97
9. F. Schlaeffer, F. Tovi, and A. Leiberman Cisplatin-induced bradycardia Drug Intell Clin Pharm 17 1983 899 901
10. I.W. Garstin, G.G. Cooper, and J.M. Hood Arterial thrombosis after treatment with bleomycin and cisplatin BMJ 300 1990 1018 1021
11. H.N. Tay, H.K. Yap, B. Murugasu, T.C. Quah, S.H. Tay, and J.W. Lim Adriamycin-Induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis J Singapore Paediatr Soc 32 1990 125 128
12. M. Igawa, H. Kadena, T. Ohkuchi, M. Ueda, T. Usui, and H. Matsuura Myocardial ischemia after treatment with methotrexate, etoposide and cisplatin Urol Int 50 1993 98 100
13. K.M. Cheriparambil, H. Vasireddy, A. Kuruvilla, B. Gambarin, M. Makan, and B.I. Saui Acute reversible cardiomyopathy and thromboembolism after cisplatin and 5-fluorouracil chemotherapy, a case report Angiology 51 2000 873 878
14. A.C. Seguro, M.H.M. Shimuzu, and L.H. Kudo Renal concentration defect induced by cisplatin Am J Nephrol 9 1989 59 65
15. W. Heuberger, S. Berardi, E. Jacky, P. Pey, and S. Krahenbuhl Increased urinary excretion of carnitine in patients treated with cisplatin Eur J Clin Pharmacol 54 1998 503 508
16. J. Bremer The role of carnitine in cell metabolism C. De Simone G. Famularo Carnitine Today 1997 Landes Bioscience, Austin Texas, USA 1 37
17. M.M. Sayed-Ahmed, M.A. Eissa, S. Kenawy, N. Mostafa, M. Calvani, and A.M. Osman Progression of cisplatin-induced nephrotoxicity in a carnitine depleted rat model Chemotherapy 50 2004 162 170
18. D.J. Paulson, J. Traxler, M. Schmidt, J. Noonan, and A.L. Shug Protection of the ischemic myocardium by l-propionylcarnitine: effects on the recovery of cardiac output after ischemia and reperfusion, carnitine transport, and fatty acid oxidation Cardiovasc Res 20 1986 536 541
19. R. Lango, R.T. Smolenski, M. Narkiewicz, J. Suchorzewska, and W. lysiak-Szydlowska Influence of l-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass Cardiovasc Res 51 1 2001 21 29
20. R. Ferrari, E. Merli, G. Cicchitelli, D. Mele, A. Fucili, and C. Ceconi Therapeutic effects of l-carnitine and propionyl-l-carnitine on cardiovascular diseases: a review Ann NY Acad Sci 1033 2004 79 91
21. N. Siliprandi, F. Di Lisa, A. Pivetta, G. Miotto, and D. Siliprandi Transport and function of l-carnitine and l-propionylcarnitine: relevance to some cardiomyopathies and cardiac ischemia Z Kardiol 76 1987 34 40
22. N. Mister, M. Noris, J. Szymczuk, N. Azzollini, M. Abbate, and L. Trochimowicz Propionyl-l-carnitine prevents renal function deterioration due to ischemia/reperfusion Kidney Int 61 2002 1064 1078
23. A. Cevese, F. Schena, and G. Cerutti Short-term hemodynamic effects of intravenous propionyl-l-carnitine in anesthetized dogs Cardiovasc Drugs Ther 5 1991 45 56
24. D.J. Paulson, and A.L. Shug Tissue specific depletion of l-carnitine in rat heart and skeletal muscle by d-carnitine Life Sci 28 1981 2931 2938
25. J.T. Whitmer l-carnitine treatment improves cardiac performance and restores high energy phosphate pools in cardiomyopathic syrian hamster Circ Res 61 1987 396 408
26. M. Tsoko, F. Beau-Seigneur, J. Greste, I. Niot, J. Demarquoy, and J. Biochot Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of l-carnitine by d-carnitine and a γ-butyrobetaine hydroxylase inhibitor Biochem Pharmacol 49 1995 1403 1410
27. S.N. Buhl, and K.Y. Jackson Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-lactate reactions in human serum at 25 30 and 37 degrees C Clin Chem 24 1978 828 831
28. A.H.B. Wu, and C.N. Bowers Evaluation and comparison of immunoinhibition and immunopreceptation methods for differentiating MB and BB from macro forms of creatine kinase isoenzymes in patients and healthy individuals Clin Chem 28 1982 2017 2021
29. G.L. Ellman Tissue sulfahydryl groups Arch Biochem Biophys 82 1959 70 77
30. H. Ohkawa, N. Ohish, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid Anal Biochem 95 1979 351 358
31. K.M. Miranda, M.G. Espey, and D.A. Wink A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite Nitric Oxide: Biol Chem 5 2001 62 71
32. A.S. Alhomida Study of the effects of theophylline-related changes in total, free short chain acyl and long-chain acyl carnitine concentrations in rat heart Toxicology 121 1997 205 213
33. A. Longo, G. Bruno, S. Curti, A. Mancinelli, and G. Miotti Determination of l-carnitine, acetyl-l-carnitine and propionyl-l-carnitine in human plasma by high-performance liquid chromatography after pre-column derivatization with I-aminoanthracene J Chromatogr B Biomed Appl 686 1996 129 139
34. H.E. Botker, M. Kimose, P. Helligso, and T.T. Nielsen Analytical evaluation of high-energy phosphate determination by high performance liquid chromatography in myocardial tissue J Mol Cell Cardiol 26 1994 41 48
35. J.G. Zhang, and W.E. Lindup Differential effects of cisplatin on the production of NADH dependent superoxide and the activity of antioxidant enzymes in rat renal cortical slices in vitro Pharmacol Toxicol 79 1996 191 198
36. D. Battelli, M. Bellei, E. Arrigoni-Martelli, U. Muscatello, and V. Bobyleva Interaction of carnitine with mitochondrial cardiolipin Biochem Biophys Acta 1117 1992 33 36
37. R.D. Olson, R.C. Boerth, J.G. Gerber, and A.S. Nies Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress Life Sci 29 1981 1393 1410
38. M. Naziroglu, A. Karaoglu, and A.O. Aksoy Selenium and high dose vitamine E administration protects cisplatin-induced oxidative damage to renal, liver, and lens tissues in rats Toxicology 195 2004 221 230
39. S. Joshi, S.K. Hasan, R. Chandra, M.M. Husain, and R.C. Srivastava Scavenging action of zinc and green tea polyphenol on cisplatin and nickel induced nitric oxide generation and lipid peroxidation in rats Biomed Environ Sci 17 2004 402 409
40. J.E. Lee, T. Nakagawa, T.S. Kim, A. Shiga, F. Iguchi, and S.H. Lee role of reactive radicals in degeneration of the auditory system of mice following cisplatin treatment Acta Otolaryngol 124 2004 1131 1135
41. D.A. Wink, J.A. Cook, D. Christodoulou, M.C. Krishna, R. Pacelli, and S. Kirn Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin Nitric Oxide 1 1997 88 94
42. K. Watanabe, A. Hess, W. Bloch, and O. Michel Expression of inducible nitric oxide synthase (iNOS/NOS II) in the vestibule of guinea pigs after the application of cisplatin Anticancer Drugs II 2000 29 32
43. R.C. Srivastava, A. Farookh, N. Ahmad, M. Misra, S.K. Hasan, and M.M. Huain Evidence for the involvement of nitric oxide in cisplatin-induced toxicity in rats Biometals 9 1996 139 142
44. K. Son Cisplatin-based interferon gamma gene-therapy of murine ovarian carcinoma Cancer Gene Ther 4 1997 391 396
45. K. Son, and Y.M. Kim In vivo cisplatin-exposed macrophages increase immunostimulant-induced nitric oxide synthesis for tumor cell killing Cancer Res 55 1995 5524 5527
46. A. Arduini, G. Mancinelli, G.L. Redatti, S. Dottori, F. Molajoni, and R.R. Ramsay Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes J Biol Chem 267 1992 12673 12681
47. M.M. Sayed-Ahmed, M.M. Khattab, M.Z. Gad, and N. Mostafa l-carnitine prevents the progression of atherosclerotic lesions in hypercholesterolemic rabbits Pharmacol Res 44 2001 235 242
48. E. Arrigoni-Martelli, and V. Caso Carnitine protects mitochondria and removes toxic acyls from xenobiotics Drugs Exp Clin Res 27 2001 27 49
49. S. Berardi, W. Heuberger, E. Jacky, and S. Krahenbuhl Renal carnitine excretion is Marker for cisplatin-induced tubular nephrotoxicity (Abstract) FASEB J 10 1996 A470
50. J.R. Neely, and H.E. Morgan Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle Annu Rev Physiol 36 1974 413 459
51. W.L. Dodson, D.S. Schan, S. Krauss, and W. Hanna Alterations of serum and urinary carnitine profile in cancer patients: hypothesis of possible significance J Am Nut 8 1989 133 142
52. A. Maestri, A. De Pasquale Ceratti, S. Cundari, C. Zanna, E. Cortesi, and L. Crino A pilot study on the effect of acettyl-l-carnitine in paclitaxel and cisplatin- induced peripheral neuropathy Tumori 91 2005 135 138
53. G. Bianchi, G. Vitali, A. Caraceni, S. Ravaglia, G. Capri, and S. Cundari Symptomatic and neurophsiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-l-carnitine Eur J Cancer 41 2005 1746 1750
54. O. Ghirardi, M. Verteehy, L. Vesci, A. canta, G. Nicolini, and S. Galbiati Chemotherapy-induced allodinia: neuroprotective effect of acetyl-l-carnitine In Vivo 19 2005 631 637
55. C. Pisano, G. Pratesi, D. Laccabue, F. Zunino, P. Lo Giudice, and A. Bellucci Paclitaxel and cisplatin-induced neurotoxicity: a protective role of acetyl-l-carnitine Clin Cancer Res 9 2003 5756 5767
56. M.M. Sayed-Ahmed, T.M. Salman, H.E. Gaballah, S.A. Abou El-Naga, R. Nicolai, and M. Calvani Propionyl-l-carnitine as protector against adriamycin-induced cardiomyopathy Pharmacol Res 43 2001 513 520
57. B. Chang, M. Nishikawa, E. Sato, K. Utsumi, and M. Inoue l-carnitine inhibits cisplatin-induced injury of the kidney and small intestine Arch Biochem Biophys 405 2002 55 64
58. S. Ahmad, H. Thomas Robertson, T.A. Golper, M. Wolfson, P. Kurtin, and L.A. Katz Multicenter trial of l-carnitine in maintenance hemodialysis patients II. Clinical and biochemical effects Kid Intern 38 1990 912 918