Indicators of marginal biotin deficiency and repletion in humans: Validation of 3-hydroxyisovaleric acid excretion and a leucine challenge

American Journal of Clinical Nutrition

Volumn 76, Issue 5, 2002, Pages 1061-1068

  Mock, Donald M ^a,b   Henrich, Cindy L ^a   Cornell, Nadine ^a   Mock, Nell I ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

3 hydroxyisovaleric acid; Biotin; Bisnorbiotin; Egg whites; Leucine; Metabolism

Indexed keywords

3 HYDROXYISOVALERIC ACID; AVIDIN; BIOTIN; BIOTIN DERIVATIVE; EGG WHITE; ISOVALERIC ACID; LEUCINE; METHYLCROTONOYL COENZYME A CARBOXYLASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; METABOLISM; REVERSED PHASE LIQUID CHROMATOGRAPHY; URINARY EXCRETION; VALIDATION PROCESS; VITAMIN DEFICIENCY;

PIERINAE;

EID: 0036828376     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/76.5.1061     Document Type: Article

References (34)

1. Mock DM, Stadler DD. Conflicting indicators of biotin status from a cross-sectional study of normal pregnancy. J Am Coll Nutr 1997;16:252-7.
2. Mock DM, Stadler D, Stratton S, Mock NI. Biotin status assessed longitudinally in pregnant women. J Nutr 1997;127:710-6.
3. Velazquez A, Martin-del-Campo C, Baez A, et al. Biotin deficiency in protein-energy malnutrition. Eur J Clin Nutr 1988;43:169-73.
4. Krause K-H, Berlit P, Bonjour J-P. Impaired biotin status in anticonvulsant therapy. Ann Neurol 1982;12:485-6.
5. Krause K-H, Berlit P, Bonjour J-P. Vitamin status in patients on chronic anticonvulsant therapy. Int J Vitam Nutr Res 1982;52:375-85.
6. Krause K-H, Kochen W, Berlit P, Bonjour J-P. Excretion of organic acids associated with biotin deficiency in chronic anticonvulsant therapy. Int J Vitam Nutr Res 1984;54:217-22.
7. Mock DM, Dyken ME. Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants. Neurology 1997;49:1444-7.
8. Mock DM, Mock NI, Lombard KA, Nelson RP. Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy. J Pediatr Gastroenterol Nutr 1998;26:245-50.
9. Said HM. Biotin bioavailability and estimated average requirement: Why bother? Am J Clin Nutr 1999;69:352-3 (editorial).
10. Mock N, Malik M, Stumbo P, Bishop W, Mock D. Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased status in experimental biotin deficiency. Am J Clin Nutr 1997;65:951-8.
11. Hardinge MG, Crooks H. Lesser known vitamins in food. J Am Diet Assoc 1961;38:240-5.
12. 12, pantothenic acid and biotin from a composite Canadian diet. Can Inst Food Sci Technol J 1978;11:71-4.
13. Bull NL, Buss DH. Biotin, pantothenic acid and vitamin E in the British household food supply. Hum Nutr Appl Nutr 1982;36A:125-9.
14. Lewis J, Buss DH. Trace nutrients: Minerals and vitamins in the British household food supply. Br J Nutr 1988;60:413-24.
15. Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem 1999;10:128-38.
16. National Research Council. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B-6, folate, vitamin B-12, pantothenic acid, biotin, and choline. In: Food and Nutrition Board. Institute of Medicine, ed. Recommended Dietary Allowances. 11th Ed. Washington, DC: National Academy Press, 1998:415.
17. Tolaymat N, Mock DM. Biotin analysis of commercial vitamin and other nutritional supplements. J Nutr 1989;119:1357-60.
18. Pennington JAT. Biotin. Bowes and Church's Food Values of Portions Commonly Used. 15th Ed. Philadelphia: JP Lippincott Co, 1989.
19. Pennington JAT, Church HN. Biotin. Bowes and Church's Food Values of Portions Commonly Used. 14th Ed. New York: Harper & Row, 1985.
20. Green NM, Toms EJ. Purification and crystallization of avidin. Biochem J 1970;118:67-70.
21. Green NM. Avidin. Adv Protein Chem 1975;29:85-133.
22. Zeman FJ. Clinical Nutrition and Dietetics. 2nd Ed. New York: Macmillan Publishing, 1991.
23. Mock DM, Malik MI. Distribution of biotin in human plasma: Most of the biotin is not bound to protein. Am J Clin Nutr 1992;56:427-32.
24. Mock DM, Lankford GL, Cazin Jr J. Biotin and biotin analogs in human urine: Biotin accounts for only half of the total. J Nutr 1993;123:1844-51.
25. Zempleni J, McCormick DB, Mock DM. Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-l-sulfoxide in human urine. Am J Clin Nutr 1997;65:508-11.
26. Mock DM, Mock NI. Serum concentrations of bisnorbiotin and biotin sulfoxide increase during both acute and chronic biotin supplementation. J Lab Clin Med 1997;129:384-8.
27. Mock DM, Heird GM. Urinary biotin analogs increase in humans during chronic supplementation: The analogs are biotin metabolites. Am J Physiol Endocrinol Metab 1997;272:83-7.
28. Mock DM. Determinations of biotin in biological fluids. In: McCormick DB, Suttie JW, Wagner C, eds. Methods in Enzymology. New York: Academic Press, 1997:265-75.
29. Mock DM, Lankford GL, Mock NI. Biotin accounts for only half of the total avidin-binding substances in human serum. J Nutr 1995;125:941-6.
30. Heingard D, Tiderstrom G. Determination of serum creatinine by a direct calorimetric method. Clin Chim Acta 1973;43:305-10.
31. Rose DB. Clinical physiology of acid-base and electrolyte disorders. In: Jeffers J, Navrozov M, eds. Renal Physiology. New York: McGraw-Hill, Inc, 1994:44-65.
32. Zar JH. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice-Hall, Inc, 1974.
33. Zempleni J, Mock DM. Marginal biotin deficiency is teratogenic. Proc Soc Exp Biol Med 2000;223:14-21.
34. Velazquez A, Zamudio S, Baez A, Murguia-Corral R, Rangel-Peniche B, Carrasco A. Indicators of biotin status: A study of patients on prolonged total parenteral nutrition. Eur J Clin Nutr 1990;44:11-6.