Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in mice

Journal of Nutrition

Volumn 139, Issue 1, 2009, Pages 154-157

  Mock, Donald M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYISOVALERIC ACID; BIOTIN; ISOVALERIC ACID; METHYLCROTONOYL COENZYME A CARBOXYLASE; PROPIONYL COENZYME A CARBOXYLASE; UNCLASSIFIED DRUG;

BIOTIN DEFICIENCY; CONFERENCE PAPER; FETUS MALFORMATION; GESTATION PERIOD; HUMAN; KIDNEY FUNCTION; NONHUMAN; PERIPHERAL LYMPHOCYTE; PREGNANCY; TERATOGENESIS; URINARY EXCRETION; VITAMIN DEFICIENCY; VITAMIN SUPPLEMENTATION;

ANIMALS; BIOTIN; CONGENITAL ABNORMALITIES; DIET; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MICE; NUTRITIONAL REQUIREMENTS; PREGNANCY; VITAMIN B COMPLEX;

MUS;

EID: 58649103991     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.095273     Document Type: Conference Paper

References (34)

1. Butterworth CE, Jr., Bendich A. Folic acid and the prevention of birth defects. In: McCormick DB, Bier DM, Goodridge AG, editors. Annual Reviews of Nutrition. Palo Alto, CA: Annual Reviews Inc.; 1996.
2. Czeizel AE. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. BMJ. 1993;306:1645-8.
3. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992;327:1832-5.
4. Marazita ML. Genetic etiologies of facial clefting. In: Mooney M, Siegel M, editors. Understanding craniofacial anomalies: The etiopathogenesis of craniosynostosis and facial clefting. New York: Wiley; 2002. p. 147-62.
5. Office of Pollution Prevention ToxinsThe Cost of Illness Handbook. In: Bouwes N, editor. Chapter iii3 Cost of Cleft Lip and Palate: US Environmental Protection Agency; 2006.
6. Murray JC. Gene/environment causes of cleft lip and/or palate. Clin Genet. 2002;61:248-56.
7. Said HM. Biotin bioavailability and estimated average requirement: why bother? Am J Clin Nutr. 1999;69:352-3.
8. Zempleni J, Mock DM. Marginal biotin deficiency is teratogenic. Proc Soc Exp Biol Med. 2000;223:14-21.
9. Karl PI, Fisher SE. Biotin transport in microvillous membrane vesicles, cultured trophoblasts and the isolated perfused cotyledon of the human placenta. Am J Physiol. 1992;262:C302-8.
10. Schenker S, Hu Z, Johnson RF, Yang Y, Frosto T, Elliott BD, Henderson GI, Mock DM. Human placental biotin transport: Normal characteristics and effect of ethanol. Alcohol Clin Exp Res. 1993;17:566-75.
11. Goldman AS. Biochemical mechanism of phenytoin-induced cleft palate. Adv Biosci. 1986;56:247-50.
12. Piddington RL, Goldman AS. Palatal development and the arachidonic acid cascade. Prog Clin Biol Res. 1985;171:295-306.
13. Katsumata M, Gupta C, Goldman AS. Glucocorticoid receptor 1B: mediator of anti-inflammatory and teratogenic functions of both glucocorticoids and phenytoin. Arch Biochem Biophys. 1985;243:385-95.
14. Kay ED, Goldman AS, Daniel JC. Common biochemical pathway of dysmorphogenesis in murine embryos: use of the glucocorticoid pathway by phenytoin. Teratog Carcinog Mutagen. 1990;10:31-9.
15. Montenegro MA, Palomino H. Induction of cleft palate in mice by inhibitors of prostaglandin synthesis. J Craniofac Genet Dev Biol. 1990; 10:83-94.
16. Watkins BA, Bain SD, Newbrey JW. Eicosanoic fatty acid reduction in the tibiotarsus of biotin-deficient chicks. Calcif Tissue Int. 1989;45: 41-6.
17. Mock DM, Johnson SB, Holman RT. Effects of biotin deficiency on serum fatty acid composition: Evidence for abnormalities in humans. J Nutr. 1988;118:342-8.
18. Kramer TR, Briske-Anderson M, Johnson SB, Holman RT. Effects of biotin deficiency on polyunsaturated fatty acid metabolism in rats. J Nutr. 1984;114:2047-52.
19. Mock DM, Mock NI, Johnson SB, Holman RT. Effects of biotin deficiency on plasma and tissue fatty acid composition: Evidence for abnormalities in rats. Pediatr Res. 1988;24:396-403.
20. Mock DM. Evidence for a pathogenic role of ω polyunsaturated fatty acid in the cutaneous manifestations of biotin deficiency. J Pediatr Gastroenterol Nutr. 1990;10:222-9.
21. Zempleni J. Sodium-dependent multivitamin transporter is regulated at the chromatin level by histone biotinylation in human Jurkat lympho-blastoma cells. J Nutr. 2008;138:163-6.
22. Mock DM, Mock NI, Stewart CW, LaBorde JB, Hansen DK. Marginal biotin deficiency is teratogenic in ICR mice. J Nutr. 2003;133: 2519-25.
23. Sealey W, Stratton SL, Hansen DK, Mock DM. Marginal maternal biotin deficiency in CD-1 mice reduces fetal mass of biotin-dependent carboxylases. J Nutr. 2005;135:973-7.
24. Mock NI, Malik MI, Stumbo PJ, Bishop WP, Mock DM. Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased status in experimental biotin deficiency. Am J Clin Nutr. 1997;65: 951-8.
25. MockDM, Henrich CL, CarnellN, MockNI. Indicatorsofmarginalbiotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge. Am J Clin Nutr. 2002;76:1061-8.
26. Stratton SL, Bogusiewicz A, Mock MM, Mock NI, Wells AM, Mock DM. Lymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans.Am J Clin Nutr. 2006;84:384-8.
27. Mock DM, Henrich CL, Carnell N, Mock NI, Swift L. Lymphocyte propionyl-CoA carboxylase and accumulation of odd-chain fatty acid in plasma and erythrocytes are useful indicators of marginal biotin deficiency. J Nutr Biochem. 2002;13:462-70.
28. Mock DM, Mock NI. Lymphocyte propionyl-CoA carboxylase activity is an early and sensitive indicator of biotin deficiency in rats, but urinary excretion of 3-hydroxyisopropionic acid is not. J Nutr. 2002;132: 1945-50.
29. Mock DM, Stadler DD. Conflicting indicators of biotin status from a cross-sectional study of normal pregnancy. J Am Coll Nutr. 1997;16: 252-7.
30. Mock DM, Stadler DD, Stratton SL, Mock NI. Biotin status assessed longitudinally in pregnant women. J Nutr. 1997;127:710-6.
31. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr. 2002;75:295-9.
32. Mock DM, Said HM. Introduction to Advances in Understanding of the Biological Role of Biotin at the Clinical, Biochemical, and Molecular Level. J Nutr. 2008;138:152-3.
33. Said HM. Cell and molecular aspects of the human intestinal biotin absorption process. J Nutr. 2008;138:158-62.
34. Beckett D. Biotin sensing at the molecular level. J Nutr. 2008;138: 167-70.