TTV DNA plasma load and its association with age, gender, and HCMV IgG serostatus in healthy adults

Age

Volumn 36, Issue 5, 2014, Pages

  Haloschan, Mats ^a   Bettesch, Rainer ^a   Görzer, Irene ^a   Weseslindtner, Lukas ^a   Kundi, Michael ^a   Puchhammer Stöckl, Elisabeth ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Aging; Anellovirus; Cytomegalovirus; Gender; Immunosenescence; TTV

Indexed keywords

IMMUNOGLOBULIN G; VIRUS DNA; ANTIIDIOTYPIC ANTIBODY;

ADULT; AGE; AGED; AGING; ANALYSIS OF VARIANCE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; GENDER; HUMAN; HUMAN CYTOMEGALOVIRUS; IMMUNE SYSTEM; IMMUNOSENESCENCE; MALE; MIDDLE AGED; NORMAL HUMAN; PERSISTENT INFECTION; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE; STUDENT T TEST; TORQUE TENO VIRUS 1; VIRUS LOAD; VIRUS REPLICATION; YOUNG ADULT; AUSTRIA; BLOOD; CYTOMEGALOVIRUS; DNA VIRUS INFECTIONS; FOLLOW UP; GENETICS; GENOTYPE; IMMUNOLOGY; PREVALENCE; RETROSPECTIVE STUDY; SEX DIFFERENCE; VERY ELDERLY; VIROLOGY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANTIBODIES, ANTI-IDIOTYPIC; AUSTRIA; CYTOMEGALOVIRUS; DNA VIRUS INFECTIONS; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HEALTHY VOLUNTEERS; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; PREVALENCE; REAL-TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; SEX FACTORS; TORQUE TENO VIRUS; VIRAL LOAD; YOUNG ADULT;

EID: 84919776598     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-014-9716-2     Document Type: Article

References (51)

1. Aberle JH, Puchhammer-Stöckl E (2012) Age-dependent increase of memory B cell response to cytomegalovirus in healthy adults. Exp Gerontol 47(8):654–657. doi:10.1016/j.exger.2012.04.008
2. Al-Moslih MI, Abuodeh RO, Hu YW (2004) Detection and genotyping of TT virus in healthy and subjects with HBV or HCV in different populations in the United Arab Emirates. J Med Virol 72(3):502–508. doi:10.1002/jmv.20017
3. Ansar Ahmed S, Karpuzoglu E, Khan D (2010) Effects of sex steroids on innate and adaptive immunity. In: Klein SL, Roberts C (eds) Sex hormones and immunity to infection. Springer, Berlin, pp 19–51. doi:10.1007/978-3-642-02155-8_2
4. Beland K, Dore-Nguyen M, Gagne MJ, Patey N, Brassard J, Alvarez F, Halac U (2013) Torque teno virus in children with orthotopic liver transplantation: new insights about a common pathogen. J Infect Dis. doi:10.1093/infdis/jit423
5. Bernardin F, Operskalski E, Busch M, Delwart E (2010) Transfusion transmission of highly prevalent commensal human viruses. Transfusion 50(11):2474–2483. doi:10.1111/j.1537-2995.2010.02699.x
6. Biagini P, de Micco P (2008) Anellovirus. In: Mahy BWJ, Regenmortel MHVV (eds) Encyclopedia of virology, Thirdth edn. Academic, Oxford, pp 104–110
7. Burra P, Masier A, Boldrin C, Calistri A, Andreoli E, Senzolo M, Zorzi M, Sgarabotto D, Guido M, Cillo U, Canova D, Bendinelli M, Pistello M, Maggi F, Palu G (2008) Torque teno virus: any pathological role in liver transplanted patients? Transpl Int 21(10):972–979. doi:10.1111/j.1432-2277.2008.00714.x
8. Carstens EB (2010) Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2009). Arch Virol 155(1):133–146. doi:10.1007/s00705-009-0547-x
9. Chen T, Vaisanen E, Mattila PS, Hedman K, Soderlund-Venermo M (2013) Antigenic diversity and seroprevalences of Torque teno viruses in children and adults by ORF2-based immunoassays. J Gen Virol 94(Pt 2):409–417. doi:10.1099/vir.0.046862-0
10. Colonna-Romano G, Akbar AN, Aquino A, Bulati M, Candore G, Lio D, Ammatuna P, Fletcher JM, Caruso C, Pawelec G (2007) Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily. Exp Gerontol 42(10):995–1002. doi:10.1016/j.exger.2007.05.006
11. Crough T, Khanna R (2009) Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev 22(1):76–98. doi:10.1128/cmr.00034-08
12. Focosi D, Maggi F, Albani M, Macera L, Ricci V, Gragnani S, Di Beo S, Ghimenti M, Antonelli G, Bendinelli M, Pistello M, Ceccherini-Nelli L, Petrini M (2010) Torquetenovirus viremia kinetics after autologous stem cell transplantation are predictable and may serve as a surrogate marker of functional immune reconstitution. J Clin Virol 47(2):189–192
13. Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128(1):92–105. doi:10.1016/j.mad.2006.11.016
14. Furman D, Hejblum BP, Simon N, Jojic V, Dekker CL, Thiébaut R, Tibshirani RJ, Davis MM (2014) Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. Proc Natl Acad Sci 111(2):869–874. doi:10.1073/pnas.1321060111
15. Gameiro CM, Romão F, Castelo-Branco C (2010) Menopause and aging: changes in the immune system—a review. Maturitas 67(4):316–320. doi:10.1016/j.maturitas.2010.08.003
16. Goronzy JJ, Weyand CM (2013) Understanding immunosenescence to improve responses to vaccines. Nat Immunol 14(5):428–436. doi:10.1038/ni.2588
17. Görzer I, Haloschan M, Jaksch P, Klepetko W, Puchhammer-Stöckl E (2014) Plasma DNA levels of Torque teno virus and immunosuppression after lung transplantation. J Heart Lung Transpl 33(3):320–323. doi:10.1016/j.healun.2013.12.007
18. Griffiths P (1999) Time to consider the concept of a commensal virus? Rev Med Virol 9(2):73–74. doi:10.1002/(sici)1099-1654(199904/06)9:2<73::aid-rmv254>3.0.co;2-5
19. Hadrup SR, Strindhall J, Køllgaard T, Seremet T, Johansson B, Pawelec G, Thor Straten P, Wikby A (2006) Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol 176(4):2645–2653
20. Hecker M, Qiu D, Marquardt K, Bein G, Hackstein H (2004) Continuous cytomegalovirus seroconversion in a large group of healthy blood donors. Vox Sang 86(1):41–44. doi:10.1111/j.0042-9007.2004.00388.x
21. Kim OY, Chae JS, Paik JK, Seo HS, Jang Y, Cavaillon JM, Lee JH (2012) Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women. Age 34(2):415–425. doi:10.1007/s11357-011-9244-2
22. Kincaid RP, Burke JM, Cox JC, de Villiers E-M, Sullivan CS (2013) A human torque teno virus encodes a microRNA that inhibits interferon signaling. PLoS Pathog 9(12):e1003818. doi:10.1371/journal.ppat.1003818
23. Klein S, Huber S (2010) Sex differences in susceptibility to viral infection. In: Klein SL, Roberts C (eds) Sex hormones and immunity to infection. Springer, Berlin, pp 93–122. doi:10.1007/978-3-642-02155-8_4
24. Klein SL, Roberts C (eds) (2010) Sex hormones and immunity to infection. Springer, Berlin Heidelberg
25. Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G (2008) Aging of the immune system as a prognostic factor for human longevity. Physiology 23(2):64–74. doi:10.1152/physiol.00040.2007
26. Maggi F, Pistello M, Vatteroni M, Presciuttini S, Marchi S, Isola P, Fornai C, Fagnani S, Andreoli E, Antonelli G, Bendinelli M (2001) Dynamics of persistent TT virus infection, as determined in patients treated with alpha interferon for concomitant hepatitis C virus infection. J Virol 75(24):11999–12004. doi:10.1128/JVI.75.24.11999-12004.2001
27. Maggi F, Pifferi M, Fornai C, Andreoli E, Tempestini E, Vatteroni M, Presciuttini S, Marchi S, Pietrobelli A, Boner A, Pistello M, Bendinelli M (2003) TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity. J Virol 77(4):2418–2425
28. Maggi F, Andreoli E, Lanini L, Fornai C, Vatteroni M, Pistello M, Presciuttini S, Bendinelli M (2005a) Relationships between total plasma load of torquetenovirus (TTV) and TTV genogroups carried. J Clin Microbiol 43(9):4807–4810. doi:10.1128/JCM.43.9.4807-4810.2005
29. Maggi F, Tempestini E, Lanini L, Andreoli E, Fornai C, Giannecchini S, Vatteroni M, Pistello M, Marchi S, Ciccorossi P, Specter S, Bendinelli M (2005b) Blood levels of TT virus following immune stimulation with influenza or hepatitis B vaccine. J Med Virol 75(2):358–365. doi:10.1002/jmv.20278
30. Mekker A, Tchang VS, Haeberli L, Oxenius A, Trkola A, Karrer U (2012) Immune senescence: relative contributions of age and cytomegalovirus infection. PLoS Pathog 8(8):e1002850. doi:10.1371/journal.ppat.1002850
31. Moen EM, Sagedal S, Bjoro K, Degre M, Opstad PK, Grinde B (2003) Effect of immune modulation on TT virus (TTV) and TTV-like-mini-virus (TLMV) viremia. J Med Virol 70(1):177–182. doi:10.1002/jmv.10356
32. Moro-Garcia MA, Alonso-Arias R, Lopez-Vazquez A, Suarez-Garcia FM, Solano-Jaurrieta JJ, Baltar J, Lopez-Larrea C (2012) Relationship between functional ability in older people, immune system status, and intensity of response to CMV. Age 34(2):479–495. doi:10.1007/s11357-011-9240-6
33. Naganuma M, Tominaga N, Miyamura T, Soda A, Moriuchi M, Moriuchi H (2008) TT virus prevalence, viral loads and genotypic variability in saliva from healthy Japanese children. Acta Paediatr 97(12):1686–1690. doi:10.1111/j.1651-2227.2008.00962.x
34. Naylor K, Li G, Vallejo AN, Lee W-W, Koetz K, Bryl E, Witkowski J, Fulbright J, Weyand CM, Goronzy JJ (2005) The influence of age on T cell generation and TCR diversity. J Immunol 174(11):7446–7452
35. Niel C, Saback FL, Lampe E (2000) Coinfection with multiple TT virus strains belonging to different genotypes is a common event in healthy Brazilian adults. J Clin Microbiol 38(5):1926–1930
36. O’Connor D, Trück J, Lazarus R, Clutterbuck EA, Voysey M, Jeffery K, Pollard AJ (2013) The effect of chronic cytomegalovirus infection on pneumococcal vaccine responses. J Infect Dis. doi:10.1093/infdis/jit673
37. Okamoto H (2009) History of discoveries and pathogenicity of TT viruses. Curr Top Microbiol Immunol 331:1–20
38. Pawelec G, Derhovanessian E (2011) Role of CMV in immune senescence. Virus Res 157(2):175–179. doi:10.1016/j.virusres.2010.09.010
39. Pawelec G, Larbi A, Derhovanessian E (2010) Senescence of the human immune system. J Comp Pathol 142(Suppl 1):S39–S44. doi:10.1016/j.jcpa.2009.09.005
40. Pinho-Nascimento CA, Leite JP, Niel C, Diniz-Mendes L (2011) Torque teno virus in fecal samples of patients with gastroenteritis: prevalence, genogroups distribution, and viral load. J Med Virol 83(6):1107–1111. doi:10.1002/jmv.22024
41. Puchhammer-Stöckl E, Aberle SW, Heinzl H (2012) Association of age and gender with alphaherpesvirus infections of the central nervous system in the immunocompetent host. J Clin Virol 53(4):356–359. doi:10.1016/j.jcv.2011.12.015
42. Roberts ET, Haan MN, Dowd JB, Aiello AE (2010) Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up. Am J Epidemiol 172(4):363–371. doi:10.1093/aje/kwq177
43. Rocchi J, Ricci V, Albani M, Lanini L, Andreoli E, Macera L, Pistello M, Ceccherini-Nelli L, Bendinelli M, Maggi F (2009) Torquetenovirus DNA drives proinflammatory cytokines production and secretion by immune cells via toll-like receptor 9. Virology 394(2):235–242. doi:10.1016/j.virol.2009.08.036
44. Sakiani S, Olsen NJ, Kovacs WJ (2013) Gonadal steroids and humoral immunity. Nat Rev Endocrinol 9(1):56–62
45. Savva GM, Pachnio A, Kaul B, Morgan K, Huppert FA, Brayne C, Moss PAH, The Medical Research Council Cognitive F, Ageing S (2013) Cytomegalovirus infection is associated with increased mortality in the older population. Aging Cell 12(3):381–387. doi:10.1111/acel.12059
46. Shaw AC, Goldstein DR, Montgomery RR (2013) Age-dependent dysregulation of innate immunity. Nat Rev Immunol 13(12):875–887. doi:10.1038/nri3547
47. Turner JE, Campbell JP, Edwards KM, Howarth LJ, Pawelec G, Aldred S, Moss P, Drayson MT, Burns VE, Bosch JA (2013) Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Age. doi:10.1007/s11357-013-9557-4
48. Tyagi AK, Pradier A, Baumer O, Uppugunduri CR, Huezo-Diaz P, Posfay-Barbe KM, Roosnek E, Ansari M (2013) Validation of SYBR Green based quantification assay for the detection of human Torque Teno virus titers from plasma. Virol J 10:191. doi:10.1186/1743-422X-10-1911743-422X-10-191
49. Wang GC, Kao WHL, Murakami P, Xue Q-L, Chiou RB, Detrick B, McDyer JF, Semba RD, Casolaro V, Walston JD, Fried LP (2010) Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study. Am J Epidemiol 171(10):1144–1152. doi:10.1093/aje/kwq062
50. Wolf J, Weinberger B, Arnold CR, Maier AB, Westendorp RGJ, Grubeck-Loebenstein B (2012) The effect of chronological age on the inflammatory response of human fibroblasts. Exp Gerontol 47(9):749–753. doi:10.1016/j.exger.2012.07.001
51. Zheng H, Ye L, Fang X, Li B, Wang Y, Xiang X, Kong L, Wang W, Zeng Y, Wu Z, She Y, Zhou X (2007) Torque teno virus (SANBAN isolate) ORF2 protein suppresses NF-kappaB pathways via interaction with IkappaB kinases. J Virol 81(21):11917–11924. doi:10.1128/JVI.01101-07