TT virus prevalence, viral loads and genotypic variability in saliva from healthy Japanese children

Acta Paediatrica, International Journal of Paediatrics

Volumn 97, Issue 12, 2008, Pages 1686-1690

  Naganuma, Masako ^a,b   Tominaga, Norio ^b   Miyamura, Tsunetake ^c   Soda, Atsushi ^d   Moriuchi, Masako ^a   Moriuchi, Hiroyuki ^a,b  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NAGASAKI UNIVERSITY HOSPITAL   (Japan)

^c Miyamura Obstetrics and Gynecology Clinic   (Japan)

^d Nagasaki City Public Health Center   (Japan)

Author keywords

Genogroup; Healthy Japanese children; Saliva; TTV; Viral load

Indexed keywords

ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; HUMAN; INFANT; JAPANESE; MAJOR CLINICAL STUDY; MALE; NORMAL HUMAN; PATHOGENICITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; SALIVA; TORQUE TENO VIRUS; VIRUS LOAD;

ADULT; AGE FACTORS; CHILD, PRESCHOOL; DNA VIRUS INFECTIONS; FEMALE; GENETIC VARIATION; GENOTYPE; HUMANS; INFANT; JAPAN; MALE; MIDDLE AGED; PREVALENCE; SALIVA; TORQUE TENO VIRUS; VIRAL LOAD;

EID: 55649106798     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2008.00962.x     Document Type: Article

References (33)

1. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Mayakawa Y, Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun 1997 241 : 92 7.
2. Okamoto H, Nishizawa T, Kato N, Ukita M, Ikeda H, Iizuka H, et al. Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology. Hepatol Res 1998 10 : 1 16.
3. Mushahwar IK, Erker JC, Muerhoff AS, Leary TP, Simons JN, Birkenmeyer LG, et al. Molecular and biophysical characterization of TT virus: evidence for a new virus family infecting humans. Proc Natl Acad Sci USA 1999 96 : 3177 82.
4. Bendinell M, Pistello M, Maggi F, Fornai C, Freer G, Vatteroni ML. Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans. Clin Microbiol Rev 2001 14 : 98 113.
5. Simmonds P. TT virus infection: a novel virus-host relationship. J Med Microbiol 2002 51 : 455 8.
6. Okamoto H, Nishizawa T, Takahashi M. TTV: molecular virology and clinical implications. In : Mushawar IK, editor. Perspectives in Medical Virology, Vol. 10. Viral Hepatitis: Molecular Biology, Diagnosis, Epidemiology and Control. Amsterdam : Elsevier, 2004 : 241 54.
7. Ross RS, Viazov S, Runde V, Schaefer UW, Roggendorf M. Detection of TT virus DNA in specimens other than blood. J Clin Virol 1999 13 : 181 4.
8. Gallian P, Biagini P, Zhong S, Touinssi M, Yeo W, Cantaloube JF, et al. TT virus: a study of molecular epidemiology and transmission of genotypes 1, 2 and 3. J Clin Virol 2000 17 : 43 9.
9. Okamoto H, Akahane Y, Ukita M, Fukuda M, Tsuda F, Miyakawa Y, et al. Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non A-G hepatitis. J Med Viol 1998 56 : 128 32.
10. Deng X, Terunuma H, Handema R, Sakamoto M, Kitamura T, Ito M, et al. Higher prevalence and viral load of TT virus in saliva than in the corresponding serum: another possible transmission route and replication site of TT virus. J Med Virol 2000 62 : 531 7.
11. Goto K, Sugiyama K, Ando T, Mizutani F, Terabe K, Tanaka K, et al. Detection rates of TT virus DNA in serum of umbilical cord blood, breast milk and saliva. Tohoku J Exp Med 2000 191 : 203 7.
12. Lin CL, Kyono W, Tongson J, Chua PK, Easa D, Yanagihara R, et al. Fecal excretion of a novel human circovirus, TT virus, in healthy children. Clin Diagn Lab Immunol 2000 7 : 960 3.
13. Maggi F, Pifferi M, Fornai C, Andreoli E, Tempestini E, Vatteroni M, et al. TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity. J Virol 2003 77 : 2418 25.
14. Ishikawa T, Hamano Y, Okamoto H. Frequent detection of TT virus in throat swabs of pediatric patients. Infection 1999 27 : 298.
15. Martínez NM, García F, García F, Álvarez M, Bernal MC, Piédrola G, et al. TT virus DNA in serum, peripheral blood mononuclear cells and semen of patients infected by HIV. AIDS 2000 14 : 1464 6.
16. Chan PKS, Tam WH, Yeo W, Cheung JLK, Zhong S, Cheng AF. High carriage rate of TT virus in the cervices of pregnant women. Clin Infect Dis 2001 32 : 1376 7.
17. Fornai C, Maggi F, Vatteroni ML, Pistello M, Bendinelli M. High prevalence of TT virus (TTV) and TTV-like minivirus in cervical swabs. J Clin Microbiol 2001 39 : 2022 4.
18. Davidson F, MacDonald D, Mokili JL, Prescott LE, Graham S, Simmonds P. Early acquisition of TT virus (TTV) in an area endemic for TTV infection. J Infect Dis 1999 179 : 1070 6.
19. Goto K, Sugiyama K, Terabe K, Mizutani F, Wada Y. Detection rates of TT virus among children who visited a general hospital in Japan. J Med Virol 1999 57 : 405 7.
20. Salakova M, Nemecek V, Konig J, Tachezy R. Age-specific prevalence, transmission and phylogeny of TT virus in the Czech Republic. BMC Infect Dis 2004 4 : 56.
21. Schroter M, Polywka S, Zollner B, Schafer P, Laufs R, Feucht HH. Detection of TT virus DNA and GB virus type C/hepatitis G virus RNA in serum and breast milk: determination of mother-to-child transmission. J Clin Microbiol 2000 38 : 745 7.
22. Yokozaki S, Fukuda Y, Nakano I, Katano Y. TT virus: a mother-to-child transmitted rather than bloodborne virus. Blood 1999 179 : 1245 8.
23. Komatsu H, Inui A, Sogo T, Kuroda K, Tanaka T, Fujisawa T. TTV infection in children born to mothers infected with TTV but not with HBV, HCV or HIV. J Med Virol 2004 74 : 499 506.
24. Morrica A, Maggi F, Vatteroni ML, Fornai C, Pistello M, Ciccorossi P, et al. TT virus: evidence for transplacental transmission. J Infect Dis 2000 181 : 803 4.
25. Saback FL, Gomes SA, de Paula VS, da Silva RS, Lewis-Ximenez LL, Niel C. Age-specific prevalence and transmission of TT virus. J Med Virol 1999 59 : 318 22.
26. Sugiyama K, Goto K, Ando T, Mizutani F, Terabe K, Kawabe Y et al. Route of TT virus infection in children. J Med Virol 1999 59 : 204 7.
27. Gerner P, Oettinger R, Gerner W, Falbrede J, Wirth S. Mother-to-infant transmission of TT virus: prevalence, extent and mechanism of vertical transmission. Pediatr Infect Dis J 2000 19 : 1074 8.
28. Maggi F, Fornai M, Vatteroni ML, Siciliano G, Menichetti F, Tascini C, et al. Low prevalence of TT virus in the cerebrospinal fluid of viremic patients with central nervous system disorders. J Med Virol 2001 65 : 418 22.
29. Maggi F, Andreoli E, Lanini L, Fornai C, Vatteroni ML, Pistello M, et al. Relationships between total plasma load of torquetenovirus (TTV) and TTV genogroups carried. J Clin Microbiol 2005 43 : 4807 10.
30. Pifferi M, Maggi F, Andreoli E, Lanini L, De Marco E, Fornai C, et al. Associations between nasal torquetenovirus load and spirometric indices in children with asthma. J Infect Dis 2005 192 : 1141 8.
31. Maggi F, Pifferi M, Tempestini E, Fornai C, Lanini L, Andreoli E, et al. TT virus loads and lymphocyte subpopulations in children with acute respiratory diseases. J Virol 2003 77 : 9081 3.
32. Maggi F, Pifferi M, Tempestini E, Lanini L, De Marco E, Fornai C, et al. Correlation between torque tenovirus infection and serum levels of eosinophil cationic protein in children hospitalized for acute respiratory diseases. J Infect Dis 2004 190 : 971 4.
33. Pifferi M, Maggi F, Caramella D, De marco E, Andreoli E, Meschi S, et al. High torquetenovirus loads are correlated with bronchiectasis and peripheral airflow limitation in children. Pediatr Infect Dis J 2006 25 : 804 8.