Torque teno virus in children who underwent orthotopic liver transplantation: New insights about a common pathogen

Journal of Infectious Diseases

Volumn 209, Issue 2, 2014, Pages 247-254

  Béland, Kathie ^a   Dore Nguyen, Michael ^a   Gagné, Marie Josée ^c   Patey, Nathalie ^a   Brassard, Julie ^c   Alvarez, Fernando ^a,b   Halac, Ugur ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c FOOD RESEARCH AND DEVELOPMENT CENTRE   (Canada)

Author keywords

Chronic hepatitis; Hepatitis E virus; Immunosuppression; Orthotopic liver transplantation; Torque Teno virus

Indexed keywords

AMINOTRANSFERASE; AZATHIOPRINE; CYCLOSPORIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; STEROID; TACROLIMUS; VIRUS DNA;

ADOLESCENT; ADULT; ALAGILLE SYNDROME; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; AUTOIMMUNE HEPATITIS; BILE DUCT ATRESIA; CHILD; CHOLESTASIS; CHRONIC HEPATITIS; CLINICAL FEATURE; COACH SYNDROME; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENOTYPE; GLYCOGEN STORAGE DISEASE TYPE 4; GRAFT RECIPIENT; HEPATITIS; HEPATITIS E; HEPATOBLASTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER FIBROSIS SCORE; LIVER INJURY; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PEDIATRICS; PREVALENCE; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; PROGRESSIVE INTRAHEPATIC FAMILIAL CHOLESTASIS; RATING SCALE; REAL TIME POLYMERASE CHAIN REACTION; TORQUE TENO VIRUS; TYROSINEMIA; VIRUS DIAGNOSIS; VIRUS LOAD; VIRUS REPLICATION;

EID: 84891530277     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit423     Document Type: Article

References (26)

1. Okamoto H. History of discoveries and pathogenicity of TT viruses. Curr Top Microbiol Immunol 2009; 331:1-20
2. Ninomiya M, Takahashi M, Nishizawa T, Shimosegawa T, Okamoto H. Development of PCR assays with nested primers specific for differential detection of three human anelloviruses and early acquisition of dual or triple infection during infancy. J Clin Microbiol 2008; 46:507-14
3. Griffiths P. Time to consider the concept of a commensal virus? Rev Med Virol 1999; 9:73-4
4. Bernardin F, Operskalski E, Busch M, Delwart E. Transfusion transmission of highly prevalent commensal human viruses. Transfusion 2010; 50:2474-83
5. Okamura A, Yoshioka M, Kikuta H, et al. Detection of TT virus sequences in children with liver disease of unknown etiology. J Med Virol 2000; 62:104-8
6. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun 1997; 241:92-7
7. Naoumov NV, Petrova EP, Thomas MG, Williams R. Presence of a newly described human DNA virus (TTV) in patients with liver disease. Lancet 1998; 352:195-7
8. Ohbayashi H, Tanaka Y, Ohoka S, et al. TT virus is shown in the liver by in situ hybridization with a PCR-generated probe from the serum TTV-DNA. J Gastroenterol Hepatol 2001; 16:424-8
9. Tawara A, Akahane Y, Takahashi M, Nishizawa T, Ishikawa T, Okamoto H. Transmission of human TT virus of genotype 1a to chimpanzees with fecal supernatant or serum from patients with acute TTV infection. Biochem Biophys Res Commun 2000; 278:470-6
10. Tokita H, Murai S, Kamitsukasa H, et al. High TT virus load as an independent factor associated with the occurrence of hepatocellular carcinoma among patients with hepatitis C virus-related chronic liver disease. J Med Virol 2002; 67:501-9
11. Halac U, Beland K, Lapierre P, et al. Chronic hepatitis E infection in children with liver transplantation. Gut 2012; 61:597-603
12. Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996; 24:289-93
13. Devalle S, Niel C. Distribution of TT virus genomic groups 1-5 in Brazilian blood donors, HBV carriers, and HIV-1-infected patients. J Med Virol 2004; 72:166-73
14. Maggi F, Andreoli E, Lanini L, et al. Relationships between total plasma load of torquetenovirus (TTV) and TTV genogroups carried. J Clin Microbiol 2005; 43:4807-10
15. Okamoto H, Takahashi M, Nishizawa T, et al. Marked genomic heterogeneity and frequent mixed infection of TT virus demonstrated by PCR with primers from coding and noncoding regions. Virology 1999; 259:428-36
16. Burra P, Masier A, Boldrin C, et al. Torque Teno Virus: Any pathological role in liver transplanted patients? Transpl Int 2008; 21:972-9
17. Shang D, Lin YH, Rigopoulou I, Chen B, Alexander GJ, Allain JP. Detection of TT virus DNA in patients with liver disease and recipients of liver transplant. J Med Virol 2000; 61:455-61
18. Sugiyama K, Goto K, Ando T, et al. TT virus infection in Japanese children: Isolates from genotype 1 are overrepresented in patients with hepatic dysfunction of unknown etiology. Tohoku J Exp Med 2000; 191:233-9
19. Maggi F, Bendinelli M. Immunobiology of the Torque teno viruses and other anelloviruses. Curr Top Microbiol Immunol 2009; 331: 65-90
20. Christensen JK, Eugen-Olsen J, Sørensen M, et al. Prevalence and prognostic significance of infection with TT virus in patients infected with human immunodeficiency virus. J Infect Dis 2000; 181:1796-9
21. Gupta P, Jagya N, Pabhu SB, Durgapal H, Acharya SK, Panda SK. Immunohistochemistry for the diagnosis of hepatitis E virus infection. J Viral Hepat 2012; 19:e177-83
22. Nishizawa Y, Tanaka E, Orii K, et al. Clinical impact of genotype 1 TT virus infection in patients with chronic hepatitis C and response of TT virus to alpha-interferon. J Gastroenterol Hepatol 2000; 15: 1292-7
23. Borkosky SS, Whitley C, Kopp-Schneider A, zur Hausen H, de Villiers EM. Epstein-Barr virus stimulates torque teno virus replication: A possible relationship to multiple sclerosis. PLoS One 2012; 7:e32160
24. Szladek G, Juhasz A, Asztalos L, et al. Persisting TT virus (TTV) genogroup 1 variants in renal transplant recipients. Arch Virol 2003; 148:841-51
25. Focosi D, Maggi F, Albani M, et al. Torquetenovirus viremia kinetics after autologous stem cell transplantation are predictable and may serve as a surrogate marker of functional immune reconstitution. J Clin Virol 2010; 47:189-92
26. Herzog D, Soglio DB, Fournet JC, Martin S, Marleau D, Alvarez F. Interface hepatitis is associated with a high incidence of late graft fibrosis in a group of tightly monitored pediatric orthotopic liver transplantation patients. Liver Transpl 2008; 14:946-55