Trichomonas vaginalis metalloproteinase induces mtor cleavage of SiHa cells

Korean Journal of Parasitology

Volumn 52, Issue 6, 2014, Pages 595-603

  Quan, Juan Hua ^a   Choi, In Wook ^b   Yang, Jung Bo ^c   Zhou, Wei ^b   Cha, Guang Ho ^b   Zhou, Yu ^a   Ryu, Jae Sook ^d   Lee, Young Ha ^b  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b Chungnam National University   (South Korea)

^c Chungnam National University College of Medicine   (South Korea)

^d Hanyang University College of Medicine   (South Korea)

Author keywords

1; 10 phenanthroline; Metalloproteinase; MTOR cleavage; SiHa cell; Trichomonas vaginalis

Indexed keywords

GP63 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; METALLOPROTEINASE; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; NONHUMAN; PARASITE LOAD; PARASITE SURVIVAL; PROTEIN CLEAVAGE; PROTEIN PROCESSING; SEQUENCE ANALYSIS; TRICHOMONAS VAGINALIS; WESTERN BLOTTING; DNA SEQUENCE; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; METABOLISM; PARASITOLOGY; PROTEIN DEGRADATION; TUMOR CELL LINE;

MAMMALIA; TRICHOMONAS VAGINALIS;

BLOTTING, WESTERN; CELL LINE, TUMOR; EPITHELIAL CELLS; HUMANS; METALLOPROTEASES; PROTEOLYSIS; SEQUENCE ANALYSIS, DNA; TOR SERINE-THREONINE KINASES; TRICHOMONAS VAGINALIS;

EID: 84919767706     PISSN: 00234001     EISSN: 17380006     Source Type: Journal    
DOI: 10.3347/kjp.2014.52.6.595     Document Type: Article

References (23)

1. Van der Pol B. Trichomonas vaginalis infection: the most prevalent nonviral sexually transmitted infection receives the least public health attention. Clin Infect Dis 2007; 44: 23-25.
2. Gómez-Barrio A, Nogal-Ruiz JJ, Montero-Pereira D, Rodríguez-Gallego E, Romero-Fernández E, Escario JA. Biological variability in clinical isolates of Trichomonas vaginalis. Mem Inst Oswaldo Cruz 2002; 97: 893-896.
3. Poole DN, McClelland RS. Global epidemiology of Trichomonas vaginalis. Sex Transm Infect 2013; 89: 418-422.
4. Arroyo R, Alderete J F. Trichomonas vaginalis surface proteinase activity is necessary for parasite adherence to epithelial cells. Infect Immun 1989; 57: 2991-2997.
5. Hirt R P, Noel CJ, Sicheritz-Ponten T, Tachezy J, Fiori PL. Tricho-monas vaginalis surface proteins: a view from the genome. Trends Parasitol 2007; 23: 540-547.
6. Ma L, Meng Q, Cheng W, Sung Y, Tang P, Hu S, Yu J. Involvement of the GP63 protease in infection of Trichomonas vaginalis. Parasitol Res 2011; 109: 71-79.
7. Sommer U, Costello CE, Hayes GR, Beach DH, Gilbert RO, Lucas JJ, Singh BN. Identification of Trichomonas vaginalis cysteine proteases that induce apoptosis in human vaginal epithelial cells. J Biol Chem 2005; 280: 23853-23860.
8. Kulkarni MM, Olson CL, Engman DM, McGwire BS. Trypanoso-ma cruzi GP63 proteins undergo stage-specific differential post-translational modification and are important for host cell infection. Infect Immun 2009; 77: 2193-2200.
9. Joshi PB, Kelly BL, Kamhawi S, Sacks DL, McMaster WR. Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor. Mol Biochem Parasitol 2002; 120: 33-40.
10. Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18: 1926-1945.
11. Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G. Mammalian TOR: a homeostatic ATP sensor. Science 2001; 294: 1102-1105.
12. Edinger AL, Thompson CB. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell 2002; 13: 2276-2288.
13. Jaramillo M, Gomez MA, Larsson O, Shio MT, Topisirovic I, Con-treras I, Luxenburg R, Rosenfeld A, Colina R, McMaster RW, Olivier M, Costa-Mattioli M, Sonenberg N. Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host Microbe 2011; 9: 331-341.
14. Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N, Pulendran B. Toll-like receptor-mediated induction of type I in-terferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat Immunol 2008; 9: 1157-1164.
15. Polivka J Jr, Janku F. Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. Pharmacol Ther 2014; 142: 164-175.
16. Alvarez-Sánchez ME, Avila-González L, Becerril-García C, Fattel-Facenda LV, Ortega-López J, Arroyo R. A novel cysteine proteinase (CP65) of Trichomonas vaginalis involved in cytotoxicity. Microb Pathog 2000; 28: 193-202.
17. Galbaugh T, Cerrito MG, Jose CC, Cutler ML. EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phos-phorylation and inhibition of HC11 cell lactogenic differentiation. BMC Cell Biol 2006; 7: 34.
18. Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 2005; 16: 525-537.
19. Matte C, Descoteaux A. Disruption of the AKT/mTOR pathway by Leishmania major promastigotes. BMC Proceedings 2011; 5 (suppl 1): 44.
20. Isnard A, Shio MT, Olivier M. Impact of Leishmania metallopro-tease GP63 on macrophage signaling. Front Cell Infect Microbiol 2012; 2: 72.
21. Slomovitz BM, Coleman RL. The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer. Clin Cancer Res 2012; 18: 5856-5864.
22. Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS. β-caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation. Cancer Lett 2011; 312: 178-188.
23. Pathania AS, Guru SK, Verma MK, Sharma C, Abdullah ST, Malik F, Chandra S, Katoch M, Bhushan S. Disruption of the PI3K/ AKT/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential oil from Monarda citriodora. Food Chem Toxicol 2013; 62: 246-254.