A novel cystein proteinase (CP65) of Trichomonas vaginalis involved in cytotoxicity

Microbial Pathogenesis

Volumn 28, Issue 4, 2000, Pages 193-202

  Alvarez Sánchez, María Elizbeth ^a   Avila González, Leticia ^a   Becerril García, Cecilia ^a   Fattel Facenda, Loriz Viridiana ^c   Ortega López, Jaime ^b,c   Arroyo, Rossana ^a,c  

^a Cinvestav   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Cysteine proteinases; Cytotoxicity; ECM degrading proteinases; Immunogenic; Trichomonas vaginalis; Virulence

Indexed keywords

COLLAGEN TYPE 4; CYSTEINE PROTEINASE; ENZYME ANTIBODY; FIBRONECTIN; HEMOGLOBIN; LAMININ; VIRULENCE FACTOR; COLLAGEN; PROTOZOON ANTIBODY;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME STABILITY; HUMAN; HUMAN CELL; IMMUNOGENICITY; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; TRICHOMONAS VAGINALIS; TRICHOMONIASIS; ANIMAL; BLOOD; CELL DEATH; CELL MEMBRANE; ENZYMOLOGY; FEMALE; HELA CELL; IMMUNOLOGY; METABOLISM; PARASITOLOGY; PATHOGENICITY; PH; RABBIT; VIRULENCE;

ANIMALS; ANTIBODIES, PROTOZOAN; CELL DEATH; CELL MEMBRANE; COLLAGEN; CYSTEINE ENDOPEPTIDASES; ENZYME STABILITY; FEMALE; FIBRONECTINS; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; RABBITS; TRICHOMONAS VAGINALIS; TRICHOMONAS VAGINITIS; VIRULENCE;

EID: 0033625137     PISSN: 08824010     EISSN: None     Source Type: Journal    
DOI: 10.1006/mpat.1999.0336     Document Type: Article

References (37)

1. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: Results from a cohort study
2. HIV and other sexually-transmitted diseases among female prostitutes in Kinshasa
3. Risk factors for prematurity and premature rupture of membranes: A prospective study of the vaginal flora in pregnancy
4. Trichomonas vaginalis associated with low birth weight and preterm delivery
5. The epidemiology of trichomonosis and the role of this infection in the development of carcinoma of the cervix
6. Is Trichomonas vaginalis a cause of cervical neoplasma?
7. Specific nature of Trichomonas vaginalis parasitism of host cell surfaces
8. Specific parasitism of purified vaginal epithelial cells by Trichomonas vaginalis
9. Pathogenic Trichomonas vaginalis cytotoxicity to cell culture monolayers
10. Contact-dependent cytopathogenic mechanisms of Trichomonas vaginalis
11. Growth and cytopathogenicity of Trichomonas vaginalis in tissue cultures
12. Trichomonas vaginalis: In vitro phagocytosis of Lactobacilli, vaginal epithelial cells, leukocytes, and erythrocytes
13. Signalling of Trichomonas vaginalis for amoeboid transformation and adhesin synthesis follows cytoadherence
14. Iron mediates Trichomonas vaginalis resistance to complement lysis
15. Analysis of human immunoglobulin-degrading cysteine proteinase of Trichomonas vaginalis
16. Molecular basis of host epithelial cell recognition by Trichomonas vaginalis
17. Isolation of a cell-detaching factor of Trichomonas vaginalis
18. Presence of laminin-binding proteins in trichomonads and their role in adhesion
19. YIGSR is the preferential laminin-1 residing adhesion sequence for Trichomonas vaginalis
20. Trichomonas vaginalis haemolysis: Evidence of functional pores formation on red cell membranes
21. Trichomonas vaginalis surface proteinase activity is necessary for parasite adherence to epithelial cells
22. Two Trichomonas vaginalis surface proteinases bind to host epithelial cells and are related to levels of cytoadherence and cytotoxicity
23. Characterization and purification of extracellular proteases of Trichomonas vaginalis
24. Specific erythrocyte binding is an additional nutrient acquisition system for Trichomonas vaginalis
25. Beta-haemolytic activity of Trichomonas vaginalis correlates with virulence
26. Characterization of Trichomonas vaginalis haemolysis
27. The use of a highly sensitive electrophoretic method to compare the proteinases of trichomonads
28. Analysis of the proteinases of representative Trichomonas vaginalis isolates
29. Proteinases in Trichomonas vaginalis and Tritrichomonas mobilensis are not exclusively of cysteine type
30. Contact-dependent disruption of the host cell membrane skeleton induced by Trichomonas vaginalis
31. The vagina of women infected with Trichomonas vaginalis has numerous proteinases and antibody to trichomonad proteinases
32. Regulation of the uterus and cervix during pregnancy and labor: Role of progesterone and nitric oxide
33. Increased matrix metalloproteinase activity and reduced tissue inhibitor of metalloproteinases-1 levels in amniotic fluids from pregnancies complicated by premature rupture of membranes
34. Antibody in sera of patient infected with Trichomonas vaginalis is to trichomonad proteinases
35. The establishment of various trichomonads of animals and man in axenic cultures
36. Cleavage of structural proteins during the assembly of the head of bacteriophage T4