Validation of the Endopep-MS method for qualitative detection of active botulinum neurotoxins in human and chicken serum

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 28, 2014, Pages 7149-7161

  Björnstad, Kristian ^a   Tevell Åberg, Annica ^a,b   Kalb, Suzanne R ^c   Wang, Dongxia ^c   Barr, John R ^c   Bondesson, Ulf ^a,b   Hedeland, Mikael ^a,b  

^a NATIONAL VETERINARY INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

Botulinum neurotoxin; Botulism; Endopep MS; MALDI Q TOF; Method validation

Indexed keywords

ANTIBODIES; BACTERIA; MASS SPECTROMETRY;

BOTULINUM NEUROTOXINS; BOTULISM; ENDOPEP-MS; MALDI-Q-TOF; METHOD VALIDATIONS;

ANIMALS;

ANIMALIA;

BOTULINUM TOXIN; PEPTIDE FRAGMENT; PROTEINASE;

ANIMAL; BIOASSAY; BLOOD; CHICKEN; COMPARATIVE STUDY; HUMAN; MASS SPECTROMETRY; METABOLISM; MOUSE; PROCEDURES; VALIDATION STUDY;

ANIMALS; BIOLOGICAL ASSAY; BOTULINUM TOXINS; CHICKENS; ENDOPEPTIDASES; HUMANS; MICE; PEPTIDE FRAGMENTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84919742377     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-8170-4     Document Type: Article

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