Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

Autophagy

Volumn 10, Issue 11, 2014, Pages 1921-1936

  Deegan, Shane ^a   Saveljeva, Svetlana ^a   Logue, Susan E ^a   Pakos Zebrucka, Karolina ^a   Gupta, Sanjeev ^a   Vandenabeele, Peter ^b,c   Bertrand, Mathieu J ^b,c   Samali, Afshin ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

Apoptosis; Autophagic cell death; Autophagy; Caspase; Endoplasmic reticulum stress; Unfolded protein response

Indexed keywords

APOPTOSOME; AUTOPHAGY PROTEIN 5; CASPASE 8; CASPASE 9; CYTOCHROME C; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PROTEIN BAK; PROTEIN BAK1; PROTEIN BAX; PROTEINASE; UNCLASSIFIED DRUG; ATG5 PROTEIN, MOUSE; ATG7 PROTEIN, MOUSE; CASP3 PROTEIN, MOUSE; CASP8 PROTEIN, MOUSE; CASP9 PROTEIN, MOUSE; CASPASE 3; FADD PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN;

APOPTOSIS; ARTICLE; ATG5 GENE; ATG7 GENE; AUTOPHAGY; CANCER CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME RELEASE; GENE; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN ASSEMBLY; ANIMAL; ENDOPLASMIC RETICULUM; FIBROBLAST; GENE EXPRESSION REGULATION; HEK293 CELL LINE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; AUTOPHAGY; CASPASE 3; CASPASE 8; CASPASE 9; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FIBROBLASTS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; SIGNAL TRANSDUCTION;

EID: 84919730791     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/15548627.2014.981790     Document Type: Article

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