Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: Relevance to depression

Neuroscience

Volumn 286, Issue , 2015, Pages 141-150

  Skupio, U ^a   Tertil, M ^a   Sikora, M ^a   Golda, S ^a   Wawrzczak Bargiela, A ^a   Przewlocki, R ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

C57BL 6J; Depression; Dexamethasone; Glucocorticoids; GR; Stress

Indexed keywords

COMPLEMENT COMPONENT C1Q; CORTICOSTERONE; DEXAMETHASONE; EXCITATORY AMINO ACID TRANSPORTER 1; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 5; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; SACCHARIN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM CHLORIDE; UNCLASSIFIED DRUG; GLUCOCORTICOID; NR3C1 PROTEIN, MOUSE; NR3C2 PROTEIN, MOUSE;

ANHEDONIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; EXPERIMENTAL DEPRESSION TEST; FORCED SWIM TEST; GLIA; HIPPOCAMPUS; HOPELESSNESS; IMMOBILIZATION; LIGHT DARK BOX TEST; MACROGLIA; MALE; MOLECULAR MECHANICS; NONHUMAN; PREFRONTAL CORTEX; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; TASTE PREFERENCE; TIME; WEIGHT REDUCTION; ANIMAL; BRAIN; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; MENTAL STRESS; METABOLISM; MOTOR ACTIVITY; MOUSE;

ANIMALS; BRAIN; DEPRESSION; DEXAMETHASONE; GLUCOCORTICOIDS; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; RNA, MESSENGER; STRESS, PSYCHOLOGICAL;

EID: 84919683177     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.11.035     Document Type: Article

References (61)

1. Anacker C., Zunszain P.A., Carvalho L.A., Pariante C.M. The glucocorticoid receptor: pivot of depression and of antidepressant treatment?. Psychoneuroendocrinology 2011, 36:415-425.
2. Bachmanov A.A., Tordoff M.G., Beauchamp G.K. Sweetener preference of C57BL/6ByJ and 129P3/J mice. Chem Senses 2001, 26:905-913.
3. Banasr M., Chowdhury G.M.I., Terwilliger R., Newton S.S., Duman R.S., Behar K.L., Sanacora G. Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol Psychiatry 2010, 15:501-511.
4. Binder E.B., et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 2004, 36:1319-1325.
5. Binder E.B. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 2009, 34(Suppl. 1):S186-S195.
6. Braun K., Antemano R., Helmeke C., Büchner M., Poeggel G. Juvenile separation stress induces rapid region- and layer-specific changes in S100ss- and glial fibrillary acidic protein-immunoreactivity in astrocytes of the rodent medial prefrontal cortex. Neuroscience 2009, 160:629-638.
7. Casarotto P.C., Andreatini R. Repeated paroxetine treatment reverses anhedonia induced in rats by chronic mild stress or dexamethasone. Eur Neuropsychopharmacol 2007, 17:735-742.
8. Chandley M.J., Szebeni K., Szebeni A., Crawford J., Stockmeier C.A., Turecki G., Miguel-Hidalgo J.J., Ordway G.A. Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder. J Psychiatry Neurosci 2013, 38:276-284.
9. Czéh B., Simon M., Schmelting B., Hiemke C., Fuchs E. Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment. Neuropsychopharmacology 2006, 31:1616-1626.
10. Dunn R.T., Kimbrell T.A., Ketter T.A., Frye M.A., Willis M.W., Luckenbaugh D.A., Post R.M. Principal components of the beck depression inventory and regional cerebral metabolism in unipolar and bipolar depression. Biol Psychiatry 2002, 51:387-399.
11. Feng Y., Rhodes P.G., Liu H., Bhatt A.J. Dexamethasone induces neurodegeneration but also up-regulates vascular endothelial growth factor A in neonatal rat brains. Neuroscience 2009, 158:823-832.
12. Fuchs E., Flïugge G. Experimental animal models for the simulation of depression and anxiety. Dialogues Clin Neurosci 2006, 8:323-333.
13. Furman D.J., Hamilton J.P., Gotlib I.H. Frontostriatal functional connectivity in major depressive disorder. Biol Mood Anxiety Disord 2011, 1:11.
14. Gabbay V., Ely B.A., Li Q., Bangaru S.D., Panzer A.M., Alonso C.M., Castellanos F.X., Milham M.P. Striatum-based circuitry of adolescent depression and anhedonia. J Am Acad Child Adolesc Psychiatr 2013, 52(628-641):e13.
15. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 2000, 23:477-501.
16. Huang Y.-L., Yu J.-P., Wang G.-H., Chen Z.-H., Wang Q., Xiao L. Effect of fluoxetine on depression-induced changes in the expression of vasoactive intestinal polypeptide and corticotrophin releasing factor in rat duodenum. World J Gastroenterol 2007, 13:6060-6065.
17. Hubler T.R., Scammell J.G. Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids. Cell Stress Chaperones 2004, 9:243-252.
18. Ising M., Horstmann S., Kloiber S., Lucae S., Binder E.B., Kern N., Künzel H.E., Pfennig A., Uhr M., Holsboer F. Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression-a potential biomarker?. Biol Psychiatry 2007, 62:47-54.
19. Ising M., Künzel H.E., Binder E.B., Nickel T., Modell S., Holsboer F. The combined dexamethasone/CRH test as a potential surrogate marker in depression. Prog Neuropsychopharmacol Biol Psychiatry 2005, 29:1085-1093.
20. Jadavji N.M., Supina R.D., Metz G.A. Blockade of mineralocorticoid and glucocorticoid receptors reverses stress-induced motor impairments. Neuroendocrinology 2011, 94:278-290.
21. Javelot H., Messaoudi M., Jacquelin C., Bisson J.F., Rozan P., Nejdi A., Lazarus C., Cassel J.C., Strazielle C., Lalonde R. Behavioral and neurochemical effects of dietary methyl donor deficiency combined with unpredictable chronic mild stress in rats. Behav Brain Res 2014, 261:8-16.
22. Katz R.J., Roth K.A., Carroll B.J. Acute and chronic stress effects on open field activity in the rat: implications for a model of depression. Neurosci Biobehav Rev 1981, 5:247-251.
23. Lang F., Strutz-Seebohm N., Seebohm G., Lang U.E. Significance of SGK1 in the regulation of neuronal function. J Physiol 2010, 588:3349-3354.
24. Lee R.S., Tamashiro K.L.K., Yang X., Purcell R.H., Harvey A., Willour V.L., Huo Y., Rongione M., Wand G.S., Potash J.B. Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice. Endocrinology 2010, 151:4332-4343.
25. Lino-de-Oliveira C., De Lima T.C.M., de Pádua Carobrez A. Structure of the rat behaviour in the forced swimming test. Behav Brain Res 2005, 158:243-250.
26. Liu W., Xu Y., Lu J., Zhang Y., Sheng H., Ni X. Swimming exercise ameliorates depression-like behaviors induced by prenatal exposure to glucocorticoids in rats. Neurosci Lett 2012, 524:119-123.
27. Li W.-Z., Li W.-P., Yao Y.-Y., Zhang W., Yin Y.-Y., Wu G.-C., Gong H.-L. Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice. Eur J Pharmacol 2010, 628:108-115.
28. MacQueen G.M., Campbell S., McEwen B.S., Macdonald K., Amano S., Joffe R.T., Nahmias C., Young L.T. Course of illness, hippocampal function, and hippocampal volume in major depression. Proc Natl Acad Sci U S A 2003, 100:1387-1392.
29. Matsumoto K., Pinna G., Puia G., Guidotti A., Costa E. Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis. Stress 2005, 8:85-93.
30. Ma X., Jiang D., Jiang W., Wang F., Jia M., Wu J., Hashimoto K., Dang Y., Gao C. Social isolation-induced aggression potentiates anxiety and depressive-like behavior in male mice subjected to unpredictable chronic mild stress. PLoS One 2011, 6:e20955.
31. McEwen B.S. Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metabolism 2005, 54:20-23.
32. Menke A., Arloth J., Putz B., Weber P., Klengel T., Mehta D., Gonik M., Rex-Haffner M., Rubel J., Uhr M., Lucae S., Deussing J.M., Muller-Myhsok B., Holsboer F., Binder E.B. Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. Neuropsychopharmacology 2012, 37:1455-1464.
33. Moguilewsky M., Raynaud J.P. Evidence for a specific mineralocorticoid receptor in rat pituitary and brain. J Steroid Biochem 1980, 12:309-314.
34. Ordway G.A., Szebeni A., Chandley M.J., Stockmeier C.A., Xiang L., Newton S.S., Turecki G., Duffourc M.M., Zhu M.-Y., Zhu H., Szebeni K. Low gene expression of bone morphogenetic protein 7 in brainstem astrocytes in major depression. Int J Neuropsychopharmacol 2012, 15:855-868.
35. Paakinaho V., Makkonen H., Jääskeläinen T., Palvimo J.J. Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions. Mol Endocrinol 2010, 24:511-525.
36. Pariante C.M. Depression, stress and the adrenal axis. J Neuroendocrinol 2003, 15:811-812.
37. Pariante C.M. Risk factors for development of depression and psychosis. Ann N Y Acad Sci 2009, 1179:144-152.
38. Pariante C.M., Miller A.H. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 2001, 49:391-404.
39. Park D.I., Kim H.G., Jung W.R., Shin M.K., Kim K.L. Mecamylamine attenuates dexamethasone-induced anxiety-like behavior in association with brain derived neurotrophic factor upregulation in rat brains. Neuropharmacology 2011, 61:276-282.
40. Parker K.J., Schatzberg A.F., Lyons D.M. Neuroendocrine aspects of hypercortisolism in major depression. Horm Behav 2003, 43:60-66.
41. Pepin M.-C., Pothier F., Barden N. Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene. Nature 1992, 355:725-728.
42. Porsolt R.D., Le Pichon M., Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977, 266:730-732.
43. Rajkowska G., Stockmeier C.A. Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. Curr Drug Targets 2013, 14:1225-1236.
44. Reul J.M., de Kloet E.R. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 1985, 117:2505-2511.
45. Ruksee N., Tongjaroenbuangam W., Mahanam T., Govitrapong P. Melatonin pretreatment prevented the effect of dexamethasone negative alterations on behavior and hippocampal neurogenesis in the mouse brain. J Steroid Biochem Mol Biol 2014, 143C:72-80.
46. Salvadore G., Nugent A.C., Lemaitre H., Luckenbaugh D.A., Tinsley R., Cannon D.M., Neumeister A., Zarate C.A., Drevets W.C. Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder. Neuroimage 2011, 54:2643-2651.
47. Scharf S.H., Liebl C., Binder E.B., Schmidt M.V., Müller M.B. Expression and regulation of the Fkbp5 gene in the adult mouse brain. PLoS One 2011, 6:e16883.
48. Schüle C., Baghai T.C., Eser D., Häfner S., Born C., Herrmann S., Rupprecht R. The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression. PLoS One 2009, 4:e4324.
49. Sigwalt A.R., Budde H., Helmich I., Glaser V., Ghisoni K., Lanza S., Cadore E.L., Lhullier F.L.R., de Bem A.F., Hohl A., de Matos F.J., de Oliveira P.A., Prediger R.D., Guglielmo L.G.A., Latini A. Molecular aspects involved in swimming exercise training reducing anhedonia in a rat model of depression. Neuroscience 2011, 192:661-674.
50. Sousa N., Cerqueira J.J., Almeida O.F.X. Corticosteroid receptors and neuroplasticity. Brain Res Rev 2008, 57:561-570.
51. Stunkard A.J., Fernstrom M.H., Price R.A., Buss E., Frank E., Kupfer D.J. Weight change in depression: influence of "disinhibition" is mediated by body mass and other variables. Psychiatry Res 1991, 38:197-200.
52. Tongjaroenbuangam W., Ruksee N., Mahanam T., Govitrapong P. Melatonin attenuates dexamethasone-induced spatial memory impairment and dexamethasone-induced reduction of synaptic protein expressions in the mouse brain. Neurochem Int 2013, 63:482-491.
53. Touma C., Gassen N.C., Herrmann L., Cheung-Flynn J., Büll D.R., Ionescu I.A., Heinzmann J.-M., Knapman A., Siebertz A., Depping A.-M., Hartmann J., Hausch F., Schmidt M.V., Holsboer F., Ising M., Cox M.B., Schmidt U., Rein T. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biol Psychiatry 2011, 70:928-936.
54. Tronche F., Kellendonk C., Kretz O., Gass P., Anlag K., Orban P.C., Bock R., Klein R., Schütz G. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 1999, 23:99-103.
55. Unemura K., Kume T., Kondo M., Maeda Y., Izumi Y., Akaike A. Glucocorticoids decrease astrocyte numbers by reducing glucocorticoid receptor expression in vitro and in vivo. J Pharmacol Sci 2012, 119:30-39.
56. Vafaei A.A., Rashidy-Pour A., Taherian A.A. Peripheral injection of dexamethasone modulates anxiety related behaviors in mice: an interaction with opioidergic neurons. Pak J Pharm Sci 2008, 21:285-289.
57. Van Rossum E.F.C., Binder E.B., Majer M., Koper J.W., Ising M., Modell S., Salyakina D., Lamberts S.W.J., Holsboer F. Polymorphisms of the glucocorticoid receptor gene and major depression. Biol Psychiatry 2006, 59:681-688.
58. Vieira C., De Lima T.C.M., Ade Carobrez P., Lino-de-Oliveira C. Frequency of climbing behavior as a predictor of altered motor activity in rat forced swimming test. Neurosci Lett 2008, 445:170-173.
59. Wang D., Zhang H., Lang F., Yun C.C. Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor. Am J Physiol Cell Physiol 2007, 292:C396-C404.
60. Wei Q., Lu X.-Y., Liu L., Schafer G., Shieh K.-R., Burke S., Robinson T.E., Watson S.J., Seasholtz A.F., Akil H. Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Proc Natl Acad Sci U S A 2004, 101:11851-11856.
61. Yao Y.-Y., Liu D.-M., Xu D.-F., Li W.-P. Memory and learning impairment induced by dexamethasone in senescent but not young mice. Eur J Pharmacol 2007, 574:20-28.