Impact of gyrA and parC mutations on quinolone resistance, doubling time, and supercoiling degree of Escherichia coli

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 4, 1999, Pages 868-875

  Bagel, Simone ^a   Hüllen, Volker ^a   Wiedemann, Bernd ^a   Heisig, Peter ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMID DNA; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DNA SUPERCOILING; ENZYME ACTIVITY; ESCHERICHIA COLI; GROWTH RATE; NONHUMAN; PLASMID; POINT MUTATION; PRIORITY JOURNAL; REPORTER GENE;

EID: 0345490831     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.4.868     Document Type: Article

References (63)

1. Aleixandre, V., A. Urios, G. Herrera, and M. Blanco. 1989. New Escherichia coli gyrA and gyrB mutations which have a graded effect on DNA supercoiling. Mol. Gen. Genet. 219:306-312.
2. Bagel, S. 1998. Personal communication.
3. Barry, A. L., P. C. Fuchs, M. A. Pfaller, S. D. Allen, and E. H. Gerlach. 1990. Prevalence of fluoroquinolone resistant bacterial isolates in four medical centers during the first quarter of 1990. Eur. J. Clin. Microbiol. Infect. Dis. 9:906-908.
4. Blanche, F., B. Cameron, F. X. Bernard, L. Maton, B. Manse, L. Ferrero, N. Ratet, C. Lecoq, A. Goniot, D. Bisch, and J. Crouzet. 1996. Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases. Antimicrob. Agents Chemother. 40:2714-2720.
5. Bolivar, F., R. L. Rodriguez, P. J. Greene, M. C. Betlach, H. L. Heyneker, and H. W. Boyer. 1977. Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Gene 2:95-113.
6. Breines, D. M., S. Ouabdesselam, E. Y. Ng, J. Tankovic, S. Shah, C. J. Soussy, and D. C. Hooper. 1997. Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV. Antimicrob. Agents Chemother. 41:175-179.
7. Cohen, S. L., L. M. McMurry, D. C. Hooper, J. S. Wolfson, and S. B. Levy. 1989. Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction. Antimicrob. Agents Chemother. 33:1318-1325.
8. Cohen, S. P., D. C. Hooper, J. S. Wolfson, K. S. Souza, L. M. McMurry, and S. B. Levy. 1988. Endogenous active efflux of norfloxacin in susceptible Escherichia coli. Antimicrob. Agents Chemother. 32:1187-1191.
9. Cullen, M. E., A. W. Wyke, R. Kuroda, and L. M. Fisher. 1989. Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones. Antimicrob. Agents Chemother. 33:886-894.
10. DiNardo, S., K. A. Voelkel, R. Sternglanz, A. E. Reynolds, and A. Wright. 1982. Escherichia coli DNA topoisomerase I mutants have compensatory mutations in DNA gyrase genes. Cell 31:43-51.
11. Dorman, C. J., A. S. Lynch, N. N. Bhriain, and C. F. Higgins. 1989. DNA supercoiling in Escherichia coli: topA mutations can be suppressed by DNA amplifications involving the tolC locus. Mol. Microbiol. 3:531-540.
12. Dove, S. L., and C. J. Dorman. 1994. The site-specific recombination system regulating expression of the type 1 fimbrial subunit gene of Escherichia coli is sensitive to changes in DNA supercoiling. Mol. Microbiol. 14:975-988.
13. Dri, A. M., P. L. Moreau, and J. Rouviere-Yaniv. 1992. Role of the histone-like proteins OsmZ and HU in homologous recombination. Gene 120:11-16.
14. Drlica, K. 1992. Control of bacterial DNA supercoiling. Mol. Microbiol. 6:425-433.
15. Everett, M. J., Y. F. Jin, V. Ricci, and L. J. Piddock. 1996. Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. Antimicrob. Agents Chemother. 40:2380-2386.
16. Freundlich, M., N. Ramani, E. Mathew, A. Sirko, and P. Tsui. 1992. The role of integration host factor in gene expression in Escherichia coli. Mol. Microbiol. 6:2557-2563.
17. Gellert, M., K. Mizuuchi, M. H. O'Dea, and H. A. Nash. 1976. DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proc. Natl. Acad. Sci. USA 73:3872-3876.
18. Gellert, M., M. H. O'Dea, T. Itoh, and J. Tomizawa. 1976. Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Proc. Natl. Acad. Sci. USA 73:4474-4478.
19. Hamilton, C. M., M. Aldea, B. K. Washburn, P. Babitzke, and S. R. Kushner. 1989. New method for generating deletions and gene replacements in Escherichia coli. J. Bacteriol. 171:4617-4622.
20. Heisig, P. 1996. Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli. Antimicrob. Agents Chemother. 40:879-885.
21. Heisig, P. 1997. Mechanisms and epidemiology of fluoroquinolone resistance in Enterobacteriaceae, p. 42-46. In R. Hakenbeck (ed.), Biospektrum special edition 1997: antibiotic resistance - recent development and future perspectives. Spektrum Akademischer Verlag, Heidelberg, Germany.
22. Heisig, P., H. Schedlelzky, and H. Falkenstein-Paul. 1993. Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coli. Antimicrob. Agents Chemother. 37:696-701.
23. Heisig, P., and R. Tschorny. 1994. Characterization of fluoroquinolone-resistant mutants of Escherichia coli selected in vitro. Antimicrob. Agents Chemother. 38:1284-1291.
24. Heisig, P., and B. Wiederaann. 1991. Use of a broad-host-range gyrA plasmid for genetic characterization of fluoroquinolone-resistant gram-negative bacteria. Antimicrob. Agents Chemother. 35:2031-2036.
25. Hooper, D. C., and J. S. Wolfson. 1992. Mechanisms of bacterial resistance to quinolones, p. 97-118. American Society for Microbiology, Washington, D.C.
26. Hooper, D. C., J. S. Wolfson, M. A. Bozza, and E. Y. Ng. 1992. Genetics and regulation of outer membrane protein expression by quinolone resistance loci nfxB, nfxC, and cfxB. Antimicrob. Agents Chemother. 36:1151-1154.
27. Hooper, D. C., J. S. Wolfson, E. Y. Ng, and M. N. Swartz. 1987. Mechanisms of action of and resistance to ciprofloxacin. Am. J. Med. 82:12-20.
28. Hoshino, K., A. Kitamura, I. Morrissey, K. Sato, J.-I. Kato, and H. Ikeda. 1994. Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition. Antimicrob. Agents Chemother. 38:2623-2627.
29. Hulton, C. S., A. Seirafi, J. C. Hinton, J. M. Sidebotham, L. Waddell, G. D. Pavitt, T. Owen-Hughes, A. Spassky, H. Buc, and C. F. Higgins. 1990. Histone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteria. Cell 63:631-642.
30. Hüllen, V., P. Heisig, and B. Wiedemann. 1997. Role of marR mutations in the development of clinical resistance of Escherichia coli against fluoroquinolones, abstr. C-64, p. 57. In Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
31. Kato, J.-I., Y. Nishinmra, Y. Imamura, H. Niki, S. Hiraga, and H. Suzuki. 1990. New topoisomerase essential for chromosome segregation in E. coli. Cell 63:393-404.
32. Kato, J.-I., Y. Nishimura, M. Yamada, H. Suzuki, and Y. Hirota. 1988. Gene organization in the region containing a new gene involved in chromosome partition in Escherichia coli. J. Bacteriol. 170:3967-3977.
33. Khodursky, A. B., E. L. Zechiedrich, and N. R. Cozzarelli. 1995. Topoisomerase IV is a target of quinolones in Escherichia coli. Proc. Natl. Acad. Sci. USA 92:11801-11805.
34. Kresken, M., and D. Hafner. 1996. Prävalenz der Antibiotikaresistenz bei klinisch wichtigen Infektionserregern in Mitteleuropa. Chemother. J. 5:225-230.
35. Kumagai, Y., J. I. Kato, K. Hoshino, T. Akasaka, K. Sato, and H. Ikeda. 1996. Ouinolone-resistant mutants of Escherichia coli DNA topoisomerase IV parC gene. Antimicrob. Agents Chemother. 40:710-714.
36. Lehn, N., J. Stower-Hoffmann, T. Kott, C. Strassner, H. Wagner, M. Kronke, and W. Schneider-Brachen. 1996. Characterization of clinical isolates of Escherichia coli showing high levels of fluoroquinolone resistance. J. Clin. Microbiol. 34:597-602.
37. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193:265-275.
38. Ma, D., M. Alberti, C. Lynch, H. Nikaido, and J. E. Hearst. 1996. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. Mol. Microbiol. 19:101-112.
39. Malik, M., A. Bensaid, J. Rouviere-Yaniv, and K. Drlica. 1996. Histone-like protein HU and bacterial DNA topology: suppression of an HU deficiency by gyrase mutations. J. Mol. Biol. 256:66-76.
40. Maneewannakul, K., and S. B. Levy. 1996. Identification of mar mutants among quinolone-resistant clinical isolates of Escherichia coli. Antimicrob. Agents Chemother. 40:1695-1698.
41. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
42. Maxwell, A. 1993. The interaction between coumarin drugs and DNA gyrase. Mol. Microbiol. 9:681-686.
43. McArn Harten, R., and L. R. Pease. 1991. SOEing, p. 217-247. In M. J. McPherson (ed.), Directed mutagenesis. IRL Press, Oxford, England.
44. Menzel, R., and M. Gellert. 1983. Regulation of the genes for E. coli DNA gyrase: homeostatic control of DNA supercoiling. Cell 34:105-113.
45. Miller, W. G., and R. W. Simons. 1993. Chromosomal supercoiling in Escherichia coli. Mol. Microbiol. 10:675-684.
46. Nakamura, S., M. Nakamura, T. Kojima, and H. Yoshida. 1989. gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli. Antimicrob. Agents Chemother. 33:254-255.
47. National Committee for Clinical Laboratory Standards. 1996. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-T. National Committee for Clinical Laboratory Standards, Villanova, Pa.
48. O'Callaghan, C. H., P. W. Muggleton, and G. W. Ross. 1968. Effects of β-lactamase from gram-negative organisms on cephalosporins and penicillins, p. 57-63. Antimicrob. Agents Chemother. 1967.
49. Oethinger, M., S. Conrad, K. Kaifel, A. Cometta, J. Bille, G. Klotz, M. P. Glauser, R. Marre, and W. V. Kern. 1996. Molecular epidemiology of fluoroquinolone-resistant Escherichia coli bloodstream isolates from patients admitted to European cancer centers. Antimicrob. Agents Chemother. 40: 387-392.
50. Oram, M., and L. M. Fisher. 1992. An Escherichia coli DNA topoisomerase I mutant has a compensatory mutation that alters two residues between functional domains of the DNA gyrase A protein. J. Bacteriol. 174:4175-4178.
51. Pavitt, G. D., and C. F. Higgins. 1993. Chromosomal domains of supercoiling in Salmonella typhimurium. Mol. Microbiol. 10:685-696.
52. Piddock, L. J. V., M. C. Hall, and R. N. Walters. 1991. Phenotypic characterization of quinolone-resistant mutants of Enterobacteriaceae selected from wild type, gyrA type and multiply-resistant (marA) type strain. J. Antimicrob. Chemother. 28:185-198.
53. Pruss, G. J., R. J. Franco, S. G. Chevalier, S. H. Manes, and K. Drlica. 1986. Effects of DNA gyrase inhibitors in Escherichia coli topoisomerase I mutants. J. Bacteriol. 168:276-282.
54. Reece, R. J., and A. Maxwell. 1991. DNA gyrase: structure and function. Crit. Rev. Biochem. Mol. Biol. 26:335-375.
55. Ruiz, J., F. Marco, P. Goni, F. Gallardo, J. Mensa, A. Trilla, T. Jimenez de Anta, and J. Vila. 1995. High frequency of mutations at codon 83 of the gyrA gene of quinolone-resistant clinical isolates of Escherichia coli. J. Antimicrob. Chemother. 36:737-738.
56. Simon, R. U., U. Priefer, and A. Pühler. 1983. A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in gram negative bacteria. Bio/Technology 1:784-790.
57. Steck, T. R., R. J. Franco, J. Y. Wang, and K. Drlica. 1993. Topoisomerase mutations affect the relative abundance of many Escherichia coli proteins. Mol. Microbiol. 10:473-481.
58. Sternglanz, R., S. DiNardo, K. A. Voelkel, Y. Nishimura, Y. Hirota, K. Becherer, L. Zumstein, and J. C. Wang. 1981. Mutations in the gene coding for Escherichia coli DNA topoisomerase I affect transcription and transposition. Proc. Natl. Acad. Sci. USA 78:2747-2751.
59. Thanassi, D. G., L. W. Cheng, and H. Mikaido. 1997. Active efflux of bile salts by Escherichia coli. J Bacteriol. 179:2512-2518.
60. Vieira, J., and J. Messing. 1982. The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19:259-268.
61. Vila, J., J. Ruiz, P. Goni, and M. T. De Anta. 1996. Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli. Antimicrob. Agents Chemother. 40:491-493.
62. Yoshida, H., M. Bogaki, M. Nakamura, and S. Nakamura. 1990. Ouinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34:1271-1272.
63. Yoshida, H., M. Bogaki, M. Nakamura, L. M. Yamanaka, and S. Nakamura. 1991. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrob. Agents Chemother. 35:1647-1650.