Sylysia 350/Eudragit S100 solid nanomatrix as a promising system for oral delivery of cyclosporine A

International Journal of Pharmaceutics

Volumn 478, Issue 2, 2015, Pages 718-725

  Dai, Wenbing ^a   Guo, Yulan ^a   Zhang, Hua ^a   Wang, Xueqing ^a   Zhang, Qiang ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Bioavailability; Cyclosporine A; Nanomatrix; pH sensitive delivery system; Poorly soluble drug

Indexed keywords

CYCLOSPORIN A; DRUG VEHICLE; EUDRAGIT; EXCIPIENT; SILICON DIOXIDE; SYLYSIA 350; UNCLASSIFIED DRUG; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; METHYLMETHACRYLATE-METHACRYLIC ACID COPOLYMER; NANOMATERIAL; POLYMETHACRYLIC ACID DERIVATIVE; AEROSIL; CYCLOSPORIN D; NANOCARRIER; NANOPARTICLE; SILICA NANOPARTICLE;

ANIMAL EXPERIMENT; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NANOPORE; NEPHROTOXICITY; NONHUMAN; PH; PHYSICAL CHEMISTRY; RAT; SCANNING ELECTRON MICROSCOPY; X RAY POWDER DIFFRACTION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; COMPARATIVE STUDY; ORAL DRUG ADMINISTRATION; SOLUBILITY; SPRAGUE DAWLEY RAT; SURFACE PROPERTY; AREA UNDER THE CURVE; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; IN VIVO STUDY; PARTICLE SIZE; SINGLE DRUG DOSE; SOLID STATE;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CYCLOSPORINE; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; IMMUNOSUPPRESSIVE AGENTS; MALE; NANOSTRUCTURES; POLYMETHACRYLIC ACIDS; RATS, SPRAGUE-DAWLEY; SILICON DIOXIDE; SOLUBILITY; SURFACE PROPERTIES;

EID: 84919667612     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.11.030     Document Type: Article

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