Self-micellizing solid dispersion of cyclosporine A with improved dissolution and oral bioavailability

European Journal of Pharmaceutical Sciences

Volumn 62, Issue , 2014, Pages 16-22

  Onoue, Satomi ^a   Suzuki, Hiroki ^a   Kojo, Yoshiki ^a   Matsunaga, Saori ^a   Sato, Hideyuki ^a   Mizumoto, Takahiro ^b,c   Yuminoki, Kayo ^d   Hashimoto, Naofumi ^d   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b Peptide Business Development Department   (Japan)

^c American Peptide Company   (United States)

^d SETSUNAN UNIVERSITY   (Japan)

Author keywords

Cyclosporine A; Dissolution; Self micellization; Solid dispersion; Stability

Indexed keywords

AMPHOPHILE; COPOLYMER; CYCLOSPORIN A; LACTATE DEHYDROGENASE; POLYSORBATE 80; ZIRCONIUM OXIDE; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; METHACRYLIC ACID DERIVATIVE; MICELLE; PHOSPHORYLCHOLINE; POLY(2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE-CO-N-BUTYL METHACRYLATE);

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; CYTOTOXICITY; DISPERSION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DYNAMIC LIGHT SCATTERING; ELECTROSPRAY MASS SPECTROMETRY; ENZYME RELEASE; HUMIDITY; LIGHT SCATTERING; MALE; MAXIMUM PLASMA CONCENTRATION; MICELLIZATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SELF MICELLIZING SOLID DISPERSION; SOLID; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; BLOOD; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; MEDICINAL CHEMISTRY; MICELLE; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; CYCLOSPORINE; DRUG STABILITY; IMMUNOSUPPRESSIVE AGENTS; MALE; METHACRYLATES; MICELLES; PHOSPHORYLCHOLINE; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84902001252     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.05.006     Document Type: Article

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