The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 387, Issue 11, 2014, Pages 1053-1068

  Staurengo Ferrari, Larissa ^a   Mizokami, Sandra S ^a   Fattori, Victor ^a   Silva, Jean J ^b   Zanichelli, Patrícia G ^c   Georgetti, Sandra R ^a   Baracat, Marcela M ^a   Da França, Luiz G ^d   Pavanelli, Wander R ^a   Casagrande, Rubia ^a   Verri, Waldiceu A ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b UNIVERSIDADE ESTADUAL DE RORAIMA   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Cytokines; GSH; Hyperalgesia; Nitric oxide; Pain; Ruthenium

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ACETIC ACID; ADENOSINE TRIPHOSPHATE; CARRAGEENAN; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GLUTATHIONE; INTERLEUKIN 1BETA; KT 5823; MYELOPEROXIDASE; NITRIC OXIDE DONOR; PHENYLQUINONE; RUTHENIUM; RUTHENIUM NITRIC OXIDE DONOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CYTOKINE; EDETIC ACID; N-(HYDROXYETHYL)ETHYLENEDIAMINETRIACETIC ACID; NITRIC OXIDE; RUTHENIUM DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HYPERALGESIA; MALE; MOUSE; NOCICEPTION; NONHUMAN; OXIDATIVE STRESS; WRITHING TEST; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; INFLAMMATION; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDETIC ACID; HYPERALGESIA; INFLAMMATION; KATP CHANNELS; MALE; MICE; NITRIC OXIDE; NITRIC OXIDE DONORS; NOCICEPTION; OXIDATIVE STRESS; RUTHENIUM COMPOUNDS; SIGNAL TRANSDUCTION;

EID: 84919622559     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-014-1030-0     Document Type: Article

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